Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marie-Josée Massariol"'
Autor:
Mireille Cartier, Gerhard G. Steinmann, George Kukolj, Jerry O. Stern, Kristi L. Berger, Joseph Scherer, Wulf O. Böcher, Marie-Josée Massariol, Yakov Datsenko, Ibtissem Triki, Martin Marquis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:698-705
A challenge to the treatment of chronic hepatitis C with direct-acting antivirals is the emergence of drug-resistant hepatitis C virus (HCV) variants. HCV with preexisting polymorphisms that are associated with resistance to NS3/4A protease inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3cf07fb110ae329652da0f0c543634
https://doi.org/10.1128/aac.01976-13
https://doi.org/10.1128/aac.01976-13
Publikováno v:
Biochemical and Biophysical Research Communications. 391:692-697
The bifunctional NS3 protease–helicase of hepatitis C virus (HCV), together with its cofactor protein NS4A, is an important target for antiviral drugs which can cure HCV infections. HCV strains are divided into six major genotypes based on sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed7eca970083022f15b673868d9583a
https://doi.org/10.1016/j.bbrc.2009.11.122
https://doi.org/10.1016/j.bbrc.2009.11.122
Autor:
Montse Llinas-Brunet, Diane Thibeault, Marie-Josée Massariol, Peter W. White, Ewald Welchner, Rock Gingras, Songping Zhao, Nathalie Goudreau
Publikováno v:
Biochemistry. 48:744-753
The NS3 protein of hepatitis C virus is unusual because it encodes two unrelated enzymatic activities in linked protease and helicase domains. It has also been intensively studied because inhibitors targeting its protease domain have potential to sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bade4ae42c10c2c7ae2f1ffc1059f6a9
https://doi.org/10.1021/bi801931e
https://doi.org/10.1021/bi801931e
Autor:
Mireille Cartier, Jean Rancourt, Anne-Marie Faucher, Marie-Josée Massariol, Peter W. White, Ewald Welchner, Jacques Archambault
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4834-4842
Human papillomaviruses (HPVs) are the causative agents of benign and malignant lesions of the epithelium. Despite their high prevalence, there is currently no antiviral drug for the treatment of HPV-induced lesions. The ATPase and helicase activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e67b29ad5296c5386f393cb4b329524
https://doi.org/10.1128/aac.49.12.4834-4842.2005
https://doi.org/10.1128/aac.49.12.4834-4842.2005
Autor:
Florence Dô, Gordon Bolger, Michel Liuzzi, Mireille Cartier, Gulrez Fazal, Jean Rancourt, Stephen W. Mason, Lynne Lamarre, Serge Landry, Josée Bordeleau, Paul Whitehead, Robert S. McCollum, Yvon Gaudette, Erika Scouten, Nathalie Dansereau, Bruno Simoneau, Nicole Lapeyre, Carole Lawetz, Marie-Josée Massariol, Lisette Lagacé
Publikováno v:
Journal of Virology. 79:13105-13115
Respiratory syncytial virus (RSV) is a major cause of respiratory illness in infants, immunocompromised patients, and the elderly. New antiviral agents would be important tools in the treatment of acute RSV disease. RSV encodes its own RNA-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2be81f11f22390bf40b4d0626edd700
https://doi.org/10.1128/jvi.79.20.13105-13115.2005
https://doi.org/10.1128/jvi.79.20.13105-13115.2005
Autor:
Dale R. Cameron, Peter W. White, Yong Wang, Steve Titolo, Louise Thauvette, Lynn M. Amon, Christiane Yoakim, Jacques Archambault, Marie-Josée Massariol, Dominique Fink, Ewald Welchner, René Coulombe
Publikováno v:
Journal of Biological Chemistry. 279:6976-6985
Interaction between the E2 protein and E1 helicase of human papillomaviruses (HPVs) is essential for the initiation of viral DNA replication. We recently described a series of small molecules that bind to the N-terminal transactivation domain (TAD) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9041dfcd68e6e3e809ee21ad43f203
https://doi.org/10.1074/jbc.m311376200
https://doi.org/10.1074/jbc.m311376200
Autor:
Marie-Josée Massariol, Chungeng Qian, Lisette Lagacé, Liang Tong, Robert Deziel, Christiane Yoakim
Publikováno v:
Nature Structural Biology. 5:819-826
Human cytomegalovirus (HCMV) protease belongs to a new class of serine proteases, with a unique polypeptide backbone fold. The crystal structure of the protease in complex with a peptidomimetic inhibitor (based on the natural substrates and covering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be20cd30638a2fd2f82e60751c5f5fe
https://doi.org/10.1038/1860
https://doi.org/10.1038/1860
Autor:
Pierre R. Bonneau, R Krogsrud, Ginette McKercher, P C McDonald, Lisette Lagacé, Carol Lawetz, D. Thibeault, Michael G. Cordingley, Marie-Josée Massariol
Publikováno v:
Biochemistry and Cell Biology. 75:795-801
The catalytic domain of herpes simplex virus protease was expressed in baculovirus-infected cells and purified in milligram quantities by ion-exchange and size-exclusion chromatography. The usefulness of this material was limited by the presence of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5607696e83197fd9e113eca6dca0b9
https://doi.org/10.1139/o97-063
https://doi.org/10.1139/o97-063
Autor:
Lisette Lagacé, Steven R. LaPlante, Chantal Grand-Maître, Daniel J. Greenwood, Stephen H. Kawai, William W. Ogilvie, Pierre R. Bonneau, Jeff A. O'Meara, Marie-Josée Massariol
Publikováno v:
Biochemistry. 36:12644-12652
A series of N-tert-butylacetyl-l-tert-butylglycyl-l-Ngamma, Ngamma-dimethylasparagyl-l-alanyl-derived inhibitors (trifluoromethyl ketone 1, pentafluoroethyl ketone, 2, methyl ketone 3, and alpha-ketoamide 4, with respective KI values of 1.1, 0.1, 210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97746932ec5948b92b29572c80fd2ea7
https://doi.org/10.1021/bi970366x
https://doi.org/10.1021/bi970366x
Autor:
Chungeng Qian, Lisette Lagacé, Marie-Josée Massariol, Pierre R. Bonneau, Liang Tong, Michael G. Cordingley
Publikováno v:
Nature. 383:272-275
HUMAN cytomegalovirus (hCMV), a herpesvirus, infects up to 70% of the general population in the United States and can cause morbidity and mortality in immunosuppressed individuals (organ-transplant recipients and AIDS patients) and congenitally infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f38d1336b4836253ccdbd0935f6e75
https://doi.org/10.1038/383272a0
https://doi.org/10.1038/383272a0