The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop

Autor: Anna Karlsson, François Boulay, Claes Dahlgren, Marie-Josèphe Rabiet, Huamei Forsman, Tudor I. Oprea, Johan Bylund

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833:1914-1923

Lipidated peptides (pepducins) can activate certain G-protein coupled receptors (GPCRs) through a unique allosteric modulation mechanism involving cytosolic receptor domains. Pepducins with the amino acid sequence of the third intracellular loop of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d864045a923633064285fc3174a64efa
https://doi.org/10.1016/j.bbamcr.2013.03.026

Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl group

Autor: Huamei Forsman, François Boulay, Michael Gabl, Malene Winther, Marie-Josèphe Rabiet, Claes Dahlgren, Sarah Line Skovbakke

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2015, 1853 (1), pp.192-200. ⟨10.1016/j.bbamcr.2014.10.021⟩

International audience; Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides, of which the tetrapeptide fMIFL is a potent activator of the neutrophil formyl peptide receptor 1 (FPR1) and the PSMα2 peptide is a poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafbec74e8d4613adbfd39149a34abd5
https://hal.archives-ouvertes.fr/hal-03518824

Phagocyte Activation by Trp-Lys-Tyr-Met-Val-Met, Acting through FPRL1/LXA4R, is not Affected by Lipoxin A4

Autor: Anna Karlsson, Claes Dahlgren, Thierry Christophe, Marie-Josèphe Rabiet, François Boulay

Publikováno v: Scandinavian Journal of Immunology. 56:470-476

Lipoxin A4 (LXA4) has been shown to bind to the leucocyte formyl peptide receptor (FPR) homologue, FPRL1, without triggering the biological activities induced by other FPRL1 agonists. We investigated the direct effect of LXA4 as well as the effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f5138fdfb91fb9bff02cc5fa8c8c9ea
https://doi.org/10.1046/j.1365-3083.2002.01149.x

Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

Autor: Jean-Luc Plantier, Yolande Genoux, Elisabetta Dejana, Yves Rival, Marie-Josèphe Rabiet, Maria Grazia Lampugnani

Publikováno v: Scopus-Elsevier

Abstract Thrombin increases endothelial permeability in a rapid and reversible way. This effect requires the catalytic activity of the enzyme and thrombin receptor engagement. Endothelial cell permeability is mostly regulated by intercellular junctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7893e0ef91b919a73d8269823f1cbe1
https://doi.org/10.1161/01.atv.16.3.488

Injection of Pseudomonas aeruginosa Exo Toxins into Host Cells Can Be Modulated by Host Factors at the Level of Translocon Assembly and/or Activity

Autor: Ina Attree, Cédric Bernarde, Julien Verove, Marie-Josèphe Rabiet, Yu-Sing Tammy Bohn, François Boulay, François Cretin

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2020, 7 (1), pp.e30488. ⟨10.1371/journal.pone.0030488⟩
PLoS ONE, Vol 7, Iss 1, p e30488 (2012)
PLoS ONE, 2020, 7 (1), pp.e30488. ⟨10.1371/journal.pone.0030488⟩

International audience; Pseudomonas aeruginosa type III secretion apparatus exports and translocates four exotoxins into the cytoplasm of the host cell. The translocation requires two hydrophobic bacterial proteins, PopB and PopD, that are found asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8749ceb16cf92beb61caf6cf308d86
http://europepmc.org/articles/PMC3267729