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Akademický článek
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Autor:
Gabriel Barrios, Anne Olechowski-Bessaguet, Mathilde Pain, Julien Bacqué-Cazenave, Laura Cardoit, Marie-Jeanne Cabirol, Didier Le Ray, François M. Lambert
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In all vertebrates, maintaining trunk posture primarily depends on descending commands originating from brainstem vestibulospinal nuclei. Despite being broadly outlined across species, the detailed anatomical and operational structure of these vestib
Externí odkaz:
https://doaj.org/article/04dcffecb1f24f94ae54ed4bf1ccdaeb
Autor:
Ilham Seffouh, Mélanie Bilong, Cédric Przybylski, Nesrine El Omrani, Salomé Poyer, Guillaume Lamour, Marie-Jeanne Clément, Rebecca-Joe Boustany, Evelyne Gout, Florence Gonnet, Romain R. Vivès, Régis Daniel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The human sulfatase HSulf-2 is one of only two known endosulfatases that play a decisive role in modulating the binding properties of heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Recently, HSulf-2 was sh
Externí odkaz:
https://doaj.org/article/74ccc652ff974500a6d2da80b5385266
Autor:
Aixiao Li, Ahmed Bouhss, Marie-Jeanne Clément, Cyril Bauvais, J. Paul Taylor, Guillaume Bollot, David Pastré
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In recent years, RNA has gained traction both as a therapeutic molecule and as a therapeutic target in several human pathologies. In this review, we consider the approach of targeting RNA using small molecules for both research and therapeutic purpos
Externí odkaz:
https://doaj.org/article/22c47e5584934302a02e842601707265
Autor:
Eloïse Colnot, Laura Cardoit, Marie-Jeanne Cabirol, Lydia Roudier, Marie-Helene Delville, Anne Fayoux, Muriel Thoby-Brisson, Laurent Juvin, Didier Morin
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Over the last two decades, nanotechnologies and the use of nanoparticles represent one of the greatest technological advances in many fields of human activity. Particles of titanium dioxide (TiO2) are one of the nanomaterials most
Externí odkaz:
https://doaj.org/article/f457bbf0d883497daf280b55dc7b860e
Autor:
Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Publikováno v:
eLife, Vol 12 (2023)
RNA-protein interactions (RPIs) are promising targets for developing new molecules of therapeutic interest. Nevertheless, challenges arise from the lack of methods and feedback between computational and experimental techniques during the drug discove
Externí odkaz:
https://doaj.org/article/fba7b44d6c2f4d60b2a3433ce6ea930d
Autor:
Marie-Jeanne Cabirol, Laura Cardoit, Gilles Courtand, Marie-Eve Mayeur, John Simmers, Olivier Pascual, Muriel Thoby-Brisson
Publikováno v:
eLife, Vol 11 (2022)
Microglia, brain-resident macrophages, play key roles during prenatal development in defining neural circuitry function, including ensuring proper synaptic wiring and maintaining homeostasis. Mammalian breathing rhythmogenesis arises from interacting
Externí odkaz:
https://doaj.org/article/0ac07cd4a5b445f5b65d20ca09b1334a
Autor:
Anastasiia Samsonova, Krystel El Hage, Bénédicte Desforges, Vandana Joshi, Marie-Jeanne Clément, Guillaume Lambert, Hélène Henrie, Nicolas Babault, Pierrick Craveur, Rachid C. Maroun, Emilie Steiner, Ahmed Bouhss, Alexandre Maucuer, Dmitry N. Lyabin, Lev P. Ovchinnikov, Loic Hamon, David Pastré
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 wit
Externí odkaz:
https://doaj.org/article/15258b4c3a3942419e49124926949c3e
Autor:
Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss
Publikováno v:
eLife, Vol 10 (2021)
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains h
Externí odkaz:
https://doaj.org/article/de0ec8831ecd4f1da1a28a35d038e526