Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marie-Hélène Champème"'
Autor:
Ivan Bièche, Marie-Hélène Champème, Rosette Lidereau, Michel Barrois, Brigitte Bressac-de Paillerets, Sylvie Mazoyer
Publikováno v:
Clinical Genetics. 65:131-136
BRCA1 and BRCA2 germline mutations, mainly point mutations and other small alterations, are responsible for most hereditary cases of breast-ovarian cancer. However, the observed frequency of BRCA1 alterations is lower than that predicted by linkage a
Autor:
Valgerdur Sigurdardottir, P Rio, Rosette Lidereau, M. W. Beckmann, Javier Benitez, Laura J. van't Veer, Siegfried Scherneck, Natasa Sever, K. Laake, Robert Winqvist, Ivan Bièche, Pia Huusko, Eva Skovlund, Susanne Seitz, Edith Olah, Jorunn E. Eyfjord, Annegien Broeks, Sarah J. Plummer, Yves-Jean Bignon, Marie Hélène Champème, Dieter Niederacher, Nigel K. Spurr, Virpi Launonen, Borut Peterlin, Anne-Marie Cleton-Jansen, Jenny Varley, Gavin R M White, Daniel Birnbaum, Anne Lise Børresen-Dale, Ana Osorio, Åke Borg, Marianna Sztan, Sigfridur Gudlaugsdottir, Graham Casey
Publikováno v:
Genes, Chromosomes and Cancer. 25:212-221
Among the chromosomal regions commonly undergoing deletions in breast tumors is 11q23.1. The genes that are targets for loss of heterozygosity (LOH) in this region is not yet established. One of the candidate genes located in this region is ATM, resp
Autor:
Gavin R M White, Risto Bloigu, Rosette Lidereau, A. Osorio, Jenny Varley, Rosa B. Barkardottir, E. Olah, Siegfried Scherneck, Robert Winqvist, N. Spurr, Marie-Hélène Champème, Ivan Bièche, Javier Benitez, Daniel Birnbaum, Pia Huusko, Virpi Launonen, Åke Borg, N. Velikonja, Dieter Niederacher, K. Laake, Anne Lise Børresen-Dale, Susanne Seitz, Peter Devilee, Julius Gudmundsson, Y. J. Bignon, Marianna Sztan, P Rio, A. M. Cleton-Jansen, M. W. Beckmann, E. K. Geirsdottir, B. Peterlin
Publikováno v:
British Journal of Cancer. 80:879-882
High frequencies of loss of heterozygosity (LOH) in chromosome 11q22-qter have been observed in various malignancies, including breast cancer. Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660-2664) have indicated that a su
Autor:
Ivan Bièche, Rosette Lidereau, Marie-Hélène Champème, Martine Olivi, Dominique Vidaud, Michel Vidaud
Publikováno v:
International Journal of Cancer. 78:661-666
Gene amplification is a common event in the progression of human cancers, and amplified oncogenes have been shown to have diagnostic, prognostic and therapeutic relevance. A kinetic quantitative polymerase-chain-reaction (PCR) method, based on fluore
Publikováno v:
British Journal of Cancer
To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surp
Autor:
Robert Callahan, M. Bistocchi, Antonio Marchetti, Z. M. Sheng, Fiamma Buttitta, Marie-Hélène Champème, Rosette Lidereau, Daniela Campani
Publikováno v:
British Journal of Cancer
A total of 80 primary human breast carcinoma DNAs were analysed for loss of heterozygosity (LOH) on the long arm of chromosome 6, using microsatellite markers whose location has been defined physically and by linkage analysis. Loss of heterozygosity
Publikováno v:
International Journal of Cancer. 82:908-910
Autor:
M. Brunet, J. C. Delarue, Catherine Andrieu, Marie-Hélène Champème, Rosette Lidereau, Kamel Hacène, Frédérique Spyratos
Publikováno v:
Breast Cancer Research and Treatment. 17:83-89
A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was ob
Publikováno v:
Molecular Carcinogenesis. 11:189-191
As the prognostic significance of the three most frequently amplified oncogenes in breast cancer (c-myc, int-2IFGF3, and c-erbB-2lnew) is still unclear, and as the amplification of these genes appears to be mutually exclusive, we investigated the pro
Autor:
Massimo Derenzini, Claudio Ceccarelli, Marie-Hélène Champème, Rosette Lidereau, Ivan Bièche, Fulvia Farabegoli, Donatella Santini
Publikováno v:
The Journal of pathology. 196(3)
The patterns of allelic loss in 28 cases of pure ductal carcinoma in situ (DCIS) and 25 cases of DCIS associated with invasive ductal carcinoma (IDC) were compared, in order to define whether pure DCIS represented an earlier stage than DCIS associate