Výsledky vyhledávání - "Marie-Hélène Canron"

L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism

Autor: Marc Deffains, Pierre-Olivier Fernagut, Margaux Teil, Benjamin Dehay, Marie-Hélène Canron, Erwan Bezard, Qin Li

Publikováno v: Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, Wiley, 2020, Online ahead of print. ⟨10.1111/nan.12678⟩
Neuropathology and Applied Neurobiology, 2020, 47 (4), pp.532-543. ⟨10.1111/nan.12678⟩

International audience; AimsWidespread accumulation of misfolded α‐synuclein aggregates is a key feature of Parkinson’s disease (PD). Although the pattern and extent of α‐synuclein accumulation through PD brains is known, the impact of chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15139eb9e65bbd4e9084641007a5e23
https://doi.org/10.1111/nan.12678

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Impaired brain insulin signalling in Parkinson's disease

Autor: Fares Bassil, Anne Vital, Marie-Hélène Canron, Nathalie Dutheil, Erwan Bezard, Pierre-Olivier Fernagut, Marie-Laure Négrier-Leibreich, Anna Delamarre, Wassilios G. Meissner

Publikováno v: Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, Wiley, 2021, ⟨10.1111/nan.12760⟩

Aims Brain insulin resistance (i.e., decreased insulin/insulin-like growth factor-1 (IGF-1) signalling) may play a role in the pathophysiology of Parkinson's disease (PD) and several anti-diabetic drugs have entered clinical development to evaluate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46484393fe9449fe734bbd46d57779a
https://pubmed.ncbi.nlm.nih.gov/34405431

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Lack of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment

Autor: Marion Bosc, Benjamin Dehay, Mégane Le Quang, Morgane Darricau, Erwan Bezard, Marie-Hélène Canron, Marie-Laure Arotcarena, Vincent Planche

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2021, ⟨10.1016/j.neurobiolaging.2021.07.009⟩
Neurobiology of Aging, 2021, ⟨10.1016/j.neurobiolaging.2021.07.009⟩

International audience; 1Lack of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) neuropathological changes in agedmacaques with memory impairmentMorgane Darricau1,Marie-Hélène Canron1, Marion Bosc2, Marie-Laure Arotçarena1, Mégane Le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd98dd89b73d23e81fbe54ebb5c6980e
https://www.hal.inserm.fr/inserm-03297050

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Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy

Autor: Wassilios G. Meissner, Benjamin Dehay, Marie-Hélène Canron, Erwan Bezard, Pierre-Olivier Fernagut, Paul A. Guerin, Miguel Lopez-Cuina, Anna Delamarre

Publikováno v: Movement Disorders
Movement Disorders, Wiley, 2020, 35 (7), pp.1163-1172. ⟨10.1002/mds.28034⟩
Movement Disorders, 2020, 35 (7), pp.1163-1172. ⟨10.1002/mds.28034⟩

International audience; Background: Multiple system atrophy (MSA) is a rare, untreatable neurodegenerative disorder characterized by accumulation of α-synuclein in oligodendroglial inclusions. As such, MSA is a synucleinopathy along with Parkinson's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de5e9edb67e575d07ee39b7505ca356
https://hal.archives-ouvertes.fr/hal-02995188

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Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction

Autor: Jing Zhang, Roberto Ceravolo, Benjamin Dehay, Wassilios G. Meissner, Chen Tian, Tao Feng, Pierre-Olivier Fernagut, Yang Huang, Han Joon Kim, Marie Hélène Canron, Anzari Atik, Zhenwei Yu, Tessandra Stewart, Francesca De Giorgi, Min Shi, Daniela Frosini, Dishun Yang, François Ichas

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2020, 143 (6), pp.1780-1797. ⟨10.1093/brain/awaa110⟩
Brain
Brain-A Journal of Neurology, 2020, 143 (6), pp.1780-1797. ⟨10.1093/brain/awaa110⟩

Transportation of key proteins via extracellular vesicles has been recently implicated in various neurodegenerative disorders, including Parkinson’s disease, as a new mechanism of disease spreading and a new source of biomarkers. Extracellular vesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe286ec4a596a1b4bd8b0bf29443668f
https://hal.archives-ouvertes.fr/hal-02995185

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Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy

Autor: Béatrice Lannes, Stéphane Thobois, Wassilios G. Meissner, Anne Vital, Alexandre Eusebio, Jean-Luc Houeto, Tatiana Witjas, François Viallet, Christine Tranchant, Dominique Guehl, Pierre-Olivier Fernagut, François Tison, Miguel Lopez-Cuina, André Maues De Paula, Nathalie Streichenberger, Philippe Damier, Marie-Hélène Canron

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, 2018, 118, pp.155-160. ⟨10.1016/j.nbd.2018.07.016⟩
Neurobiology of Disease, Vol 118, Iss, Pp 155-160 (2018)
Neurobiology of Disease, Elsevier, 2018, 118, pp.155-160. ⟨10.1016/j.nbd.2018.07.016⟩

Slowly progressive, levodopa-responsive multiple system atrophy (MSA) may be misdiagnosed as Parkinson's disease (PD). Deep brain stimulation (DBS) is mostly ineffective in these patients and may even worsen the clinical course. Here we assessed whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7479f7c3fcc1bc8d3ea6073483c6e679
https://hal.science/hal-02347480

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Systemic Gene Delivery by Single-Dose Intracardiac Administration of scAAV2/9 and scAAV2/rh10 Variants in Newborn Rats

Autor: Nathalie Dutheil, Erwan Bezard, Sandra Dovero, Mathieu Bourdenx, Benjamin Dehay, Lucie Chansel-Debordeaux, Clement Jimenez, Marie-Hélène Canron

Publikováno v: Human gene therapy methods
Human gene therapy methods, New Rochelle, NY : Mary Ann Liebert, 2018, 29 (4), pp.189-199. ⟨10.1089/hgtb.2017.192.r3⟩
Human gene therapy methods, 2018, 29 (4), pp.189-199. ⟨10.1089/hgtb.2017.192.r3⟩

International audience; AbstractRecombinant adeno-associated virus serotype 9 (rAAV2/9) and pseudotype rhesus-10 (rAAV2/rh10) are used for gene delivery, especially into the central nervous system. Both serotypes cross the blood-brain barrier and med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74b35f487ba00697856c13e97724d12
https://pubmed.ncbi.nlm.nih.gov/30064266

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Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy

Autor: Anne Vital, François Tison, Arnaud Monvoisin, Fares Bassil, Marie-Hélène Canron, Pierre-Olivier Fernagut, Wassilios G. Meissner

Publikováno v: Movement Disorders. 30:1802-1812

Background MSA is a sporadic progressive neurodegenerative disorder characterized by a variable combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. The pathological hallmark of MSA is the accumulation of alpha-synuclein aggrega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3307539e4cb8e53bcafbf81690ed3060
https://doi.org/10.1002/mds.26329

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