Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marie-Gabrielle Braun"'
Autor:
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular
Externí odkaz:
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Autor:
Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, Cameron L. Noland, Jingyu Diao, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Janina Reeder, Georgette M. Castanedo, Keira Garland, Laszlo Komuves, Meredith Sagolla, Cary D. Austin, Jeremy Murray, Yiming Xu, Zora Modrusan, Min Xu, Emily J. Hanan, Sharookh B. Kapadia
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Clinical development of antibiotics with novel mechanisms of action to kill pathogenic bacteria is challenging, in part, due to the inevitable emergence of resistance. A phenomenon of potential clinical importance that is broadly overlooked
Externí odkaz:
https://doaj.org/article/ad7dc0127d394ca78d233d455e860331
Autor:
Emily J. Hanan, Marie-Gabrielle Braun, Robert A. Heald, Calum MacLeod, Connie Chan, Saundra Clausen, Kyle A. Edgar, Charles Eigenbrot, Richard Elliott, Nicholas Endres, Lori S. Friedman, Emily Gogol, Xiao-Hui Gu, Rebecca Hong Thibodeau, Philip S. Jackson, James R. Kiefer, Jamie D. Knight, Michelle Nannini, Raman Narukulla, Amanda Pace, Jodie Pang, Hans E. Purkey, Laurent Salphati, Deepak Sampath, Stephen Schmidt, Steve Sideris, Kyung Song, Swathi Sujatha-Bhaskar, Mark Ultsch, Heidi Wallweber, Jianfeng Xin, SiewKuen Yeap, Amy Young, Yu Zhong, Steven T. Staben
Publikováno v:
Journal of medicinal chemistry. 65(24)
Small molecule inhibitors that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway have received significant interest for the treatment of cancers. The class I isoform PI3Kα is most commonly associated with solid tumors via gene amplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085a38e6723d04c169025fcfa48abbbc
https://pubmed.ncbi.nlm.nih.gov/36455032
https://pubmed.ncbi.nlm.nih.gov/36455032
Autor:
Breanna Canter, Benjamin T. Walters, Alfred Lammens, Peter Liu, Avi Ashkenazi, Wilson Phung, Weiru Wang, Kevin R Clark, Adrien Le Thomas, Joachim Rudolph, Heidi J.A. Wallweber, Elena Ferri, Eric S. Day, Kyle Mortara, Maureen Beresini, Marie-Gabrielle Braun, Yung-Chia A. Chen, Susan Kaufman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory lumenal domain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains. Exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bd7a014003dc6f7f6d9ef04c6b5f4a
https://doaj.org/article/b949b998bea04b119070c87d6eced201
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Autor:
Marie-Gabrielle Braun, Georgette Castanedo, Samantha A. Green, Mingshuo Zeng, Joseph Carpenter, Antonella Converso, Izzat T. Raheem, Anthony J. Roecker, Akshay A. Shah, Laurent Debien, T.G. Murali Dhar, Lauren M. Holder, J. Robert Merritt, Kevin M. Peese, Denise G. Grünenfelder, Julian C. Lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b06c6de4c5477f156e05341f47d237
https://doi.org/10.29200/acsmedchemrev-v56.ch21
https://doi.org/10.29200/acsmedchemrev-v56.ch21
Autor:
Marie-Gabrielle Braun, Alba Díaz-Rodríguez, Louis Diorazio, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Lucie E. Lovelle, Mark McLaws, Andrew T. Parsons, Paul Richardson, Gheorghe-Doru Roiban, Alan Steven, Jack A. Terrett, Timothy White, Jingjun Yin
Publikováno v:
Organic Process Research & Development. 23:1118-1133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d2f8a6a8f6c623f013b1d16f2c3d2f
https://doi.org/10.1021/acs.oprd.9b00158
https://doi.org/10.1021/acs.oprd.9b00158
Autor:
Georgette Castanedo, Izzat T. Raheem, Akshay A. Shah, J. Robert Merritt, Denise C. Grünenfelder, Catherine A. Bolger, Anthony J. Roecker, T. G. Murali Dhar, Adam K. Charnley, Marie-Gabrielle Braun, Mingshuo Zeng, Kevin Peese, Erika Araujo, Antonella Converso
Publikováno v:
2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviews
2020 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc689e8e25238454516b57ef2cdd515c
https://doi.org/10.29200/acsmedchemrev-v55.ch27
https://doi.org/10.29200/acsmedchemrev-v55.ch27
Autor:
Sanjay Srivastava, Susan Kaufman, Joachim Rudolph, Ghiro Elise, Heidi J.A. Wallweber, Jean-Philippe Leclerc, Beveridge Ramsay, Liang Zhao, Marie-Gabrielle Braun, Lemire Alexandre, Mélissa Leblanc, Alexandre Larivée, Cuong Ly, Weiru Wang, Avi Ashkenazi, Maureen Beresini, Jacob Schwarz, Paul Gibbons, Kevin R Clark
Publikováno v:
ACS Med Chem Lett
[Image: see text] Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082aa3dbc959d40a4b3123339657e04c
https://europepmc.org/articles/PMC7734639/
https://europepmc.org/articles/PMC7734639/
Autor:
Donghong Yan, Keira Garland, Marie-Gabrielle Braun, Yiming Xu, Anand Kumar Katakam, Emily J. Hanan, Yutian Peng, Jing Kang, Meredith Sagolla, Jingyu Diao, Homer Pantua, Cary D. Austin, Cameron L. Noland, Sharookh B. Kapadia, Georgette Castanedo, Zora Modrusan, Min Xu, Susan L. Gloor, Janina Reeder, Elizabeth Skippington, László G. Kömüves, Jeremy Murray
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
mBio
mBio
Despite increasing evidence suggesting that antibiotic heteroresistance can lead to treatment failure, the significance of this phenomena in the clinic is not well understood, because many clinical antibiotic susceptibility testing approaches lack th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7614b3130f320eea77990e66dc24dc72
https://journals.asm.org/doi/10.1128/mBio.02018-20
https://journals.asm.org/doi/10.1128/mBio.02018-20
Autor:
Keira Garland, Richard Pastor, Gauri Deshmukh, Min Xu, Emily J. Hanan, Paul Gibbons, Yi-Chen Chen, Susan L. Gloor, Sharookh B. Kapadia, Homer Pantua, Sharada Labadie, Rongbao Hua, Yiming Xu, Marie-Gabrielle Braun, Yuhong Fu, Craig Stivala, Xiongcai Liu, Georgette Castanedo, Jonathan Cheong, Daniels Blake, Hao Zheng, Daniel J. Burdick, Yun-Xing Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(20)
Discovery of novel classes of Gram-negative antibiotics with activity against multi-drug resistant infections is a critical unmet need. As an essential member of the lipoprotein biosynthetic pathway, lipoprotein signal peptidase II (LspA) is an attra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182cd264e9ec08564bbb5c07f04cdf6d
https://pubmed.ncbi.nlm.nih.gov/32768648
https://pubmed.ncbi.nlm.nih.gov/32768648