Evaluating drug interaction potential from cytokine release syndrome using a physiologically based pharmacokinetic model: A case study of teclistamab

Autor: Marie‐Emilie Willemin, Shun Xin Wang Lin, Loeckie De Zwart, Liviawati S. Wu, Xin Miao, Raluca Verona, Arnob Banerjee, Baolian Liu, Rachel Kobos, Ming Qi, Daniele Ouellet, Jenna D. Goldberg, Suzette Girgis

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 7, Pp 1117-1129 (2024)

Abstract Cytokine release syndrome (CRS) was associated with teclistamab treatment in the phase I/II MajesTEC‐1 study. Cytokines, especially interleukin (IL)‐6, are known suppressors of cytochrome P450 (CYP) enzymes' activity. A physiologically b

Externí odkaz: https://doaj.org/article/0dd1551fb54644b2acd2b604cad8206a

Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions

Autor: Thomas K van der Made, Jan Snoeys, Lieve Dillen, Ils Pijpers, Daniel Scotcher, Aleksandra Galetin, Sophie Jonkers, Mario Monshouwer, Amin Rostami-Hodjegan, Frank Jacobs, Annett Kunze, Kathleen Steemans, An Tuytelaars, Marie-Emilie Willemin

Publikováno v: Willemin, M, Van Der Made, T K, Pijpers, I, Dillen, L, Kunze, A, Jonkers, S, Steemans, K, Tuytelaars, A, Jacobs, F, Monshouwer, M, Scotcher, D, Rostami-hodjegan, A, Galetin, A & Snoeys, J 2021, ' Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions ', Clinical Pharmacokinetics . https://doi.org/10.1007/s40262-021-01004-2

BackgroundEndogenous biomarkers are promising tools to assess transporter-mediated drug–drug interactions early in humans.MethodsWe evaluated on a common and validated in vitro system the selectivity of 4-pyridoxic acid (PDA), homovanillic acid (HV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed80425cf49862269c9ed5238be7d0
https://doi.org/10.1007/s40262-021-01004-2

Characterization of the modes of action and dose-response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach

Autor: Marie-Emilie Willemin, Annie Lumen

Publikováno v: Toxicology and Applied Pharmacology. 365:84-100

Current practices for evaluating the cumulative risk of thyroid-active chemical mixtures (perchlorate, thiocyanate, nitrate) focus on the inhibition of thyroidal iodide uptake via the sodium iodide symporter (NIS) as the mode of action for potency eq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41b165f891670fbf7f8227bb29cc92e
https://doi.org/10.1016/j.taap.2019.01.007

Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations

Autor: Annie Lumen, Marie-Emilie Willemin

Publikováno v: Critical Reviews in Toxicology. 47:543-569

Exposure of the population to thiocyanate is predominantly through the diet and cigarette smoke. Thiocyanate is a potential thyroid disruptor due to its capacity to inhibit the uptake of iodide by the thyroid. Thiocyanate also interacts with the enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6feac83362e606db9af96fe3440b4a57
https://doi.org/10.1080/10408444.2017.1281590

PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats

Autor: Christian Moesch, Sophie Desmots, Florence Anna Zeman, Marie-Emilie Willemin, Céline Brochot, Eric Leclerc, Rozenn Le Grand, François Lestremau

Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2016, 294, pp.65-77. ⟨10.1016/j.taap.2016.01.011⟩

International audience; Permethrin, a pyrethroid insecticide, is suspected to induce neuronal and hormonal disturbances in humans. The widespread exposure of the populations has been confirmed by the detection of the urinary metabolites of permethrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a015a89e50c4bb58b68080cefd3d04b
https://hal-ineris.archives-ouvertes.fr/ineris-01862928/file/2016-001_post-print.pdf