PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Autor: Bernard S. Lopez, Najat Magroun, Giuditta Illuzzi, Carole Beck, Valérie Schreiber, Laurent Gauthier, Anbazhagan Rajendran, Françoise Dantzer, Marie-Elise Bonnet, Philippe Rondé, Ralph Scully, François D. Boussin, Christian Boehler, Josée Guirouilh Barbat

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42, pp.5616-5632
Nucleic Acids Research, 2014, 42 (9), pp.5616-5632. ⟨10.1093/nar/gku174⟩
Nucleic Acids Research, Oxford University Press, 2014, 42 (9), pp.5616-5632. ⟨10.1093/nar/gku174⟩

The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca331903f04e160d9a609bfa9d3156b
https://doi.org/10.1093/nar/gku174

in vivo-jetPEI®, a non-viral vector of choice for nucleic acid-based therapies

Autor: Kedinger, Valérie, Belguise, Pascale, Anne-Laure Bellemin, Marie-Elise Bonnet, Guérin-Peyrou, Géraldine, Erbacher, Patrick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ecad8d53bdc2949a01b5654464e147f

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

Autor: Patrick Erbacher, Omar Zounib, Valérie Kedinger, Jean-Paul Behr, Pattabhiraman Shankaranarayanan, Marie-Elise Bonnet, Mélanie Messmer, Aline Meulle, Jean-Baptiste Gossart, Elodie Benoit, Anne-Laure Bolcato-Bellemin

Publikováno v: BMC Cancer

Background Melanoma represents one of the most aggressive and therapeutically challenging malignancies as it often gives rise to metastases and develops resistance to classical chemotherapeutic agents. Although diverse therapies have been generated,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29aad5551f83150c87459d4459606a1f
https://pubmed.ncbi.nlm.nih.gov/23835136

Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery

Autor: Patrick Neuberg, Patrick Erbacher, Marie-Elise Bonnet, Rym Ghaddab, Ghislaine Morvan-Dubois, Silvia Alejandra López-Juárez, Fabrice Stock, Anne-Laure Bolcato-Bellemin, Jacqueline Pierre-Simons, Barbara A. Demeneix, Sylvie Remaud, Marie Stéphanie Clerget-Froidevaux

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Molecular Therapy. Nucleic Acids
Molecular Therapy — Nucleic Acids; Vol 2

RNA interference (RNAi) is a major tool for basic and applied investigations. However, obtaining RNAi data that have physiological significance requires investigation of regulations and therapeutic strategies in appropriate in vivo settings. To exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e41ddc83627806b4dd9322d9f7acf6
http://www.sciencedirect.com/science/article/pii/S2162253116301482

Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response

Autor: Patrick Erbacher, Marie-Elise Bonnet, Anne-Laure Bolcato-Bellemin

Publikováno v: Pharmaceutical research. 25(12)

The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41144da36a8f954a878012002895ca59
https://pubmed.ncbi.nlm.nih.gov/18709489