Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile

Autor: Maxime Bergere, Agnès Pottier, Laurent Levy, Matthieu Germain, Marie-Edith Meyre, Francis Mpambani, Marion Paolini, Laurence Poul, Céline Berjaud

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Many therapeutic agents offer a low useful dose (dose responsible for efficacy)/useless dose (dose eliminated or responsible for toxicity) ratio, mainly due to the fact that therapeutic agents must ensure in one single object all the functions requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cff1c0c3c1ed10d510bdbb6f493cba9
http://europepmc.org/articles/PMC5859131

MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery

Autor: Agnès Pottier, Marie-Edith Meyre, Matthieu Germain, Clemens Bos, Laurent Levy, Alexandru Cernicanu, Chrit T. W. Moonen, Baudouin Denis de Senneville, P. Smirnov, Cyril Lorenzato

Publikováno v: Contrast Media & Molecular Imaging. 8:185-192

Improved drug delivery control during chemotherapy is a major concern to increase their therapeutic index. Drug accumulation in solid tumor can be visualized using MRI contrast agent such as iron oxide nanoparticles encapsulated in liposomes. Once ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba8b608010bf9f1060e48492e6f5d6ba
https://doi.org/10.1002/cmmi.1515

High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes

Autor: Jean-Michel Escoffre, Ayache Bouakaz, Christophoros Mannaris, Anthony Novell, Michalakis Averkiou, Marie-Edith Meyre, Matthieu Germain, Laëtitia Rioc

Publikováno v: AIP Conference Proceedings.

Local drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin from thermosensitive liposomes (Dox-TSL) into human glioblastoma (U-87MG) cells. Us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af2ebb2166c39f52274a169d716e9b7a
https://doi.org/10.1063/1.4757315

Multilamellar liposomes entrapping aminosilane-modified maghemite nanoparticles: 'magnetonions'

Autor: Etienne Duguet, Olivier Lambert, Stéphane Mornet, François Dole, Sylvain Trépout, Chrystel Faure, Rodolphe Clérac, Marie-Edith Meyre, Frédéric Nallet

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2010, 12 (39), pp.12794-12801. ⟨10.1039/c0cp00231c⟩

International audience; 4.6 nm-sized aminosilane-modified maghemite (γ-Fe(2)O(3)) nanoparticles (aMNPs) were synthesized and encapsulated into onion-type multilamellar vesicles of soybean phosphatidylcholine (90%mol) and monoolein (10%mol). The magn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a302fb246e0217f9acaa30ef85cb8eb
https://hal.archives-ouvertes.fr/hal-00530393

A new bio-inspired route to metal-nanoparticle-based heterogeneous catalysts

Autor: Damien P. Debecker, Chrystel Faure, Eric M. Gaigneaux, Marie-Edith Meyre, Alain Derré

Publikováno v: Small
Small, Wiley-VCH Verlag, 2008, 4 (10), pp.1806-1812. ⟨10.1002/smll.200800304⟩

7 pages; International audience; Onion-type multilamellar vesicles are made of concentric bilayers of organic surfactant and are mainly known for their potential applications in biotechnology. They can be used as microreactors for the spontaneous and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baff5fa5df1b13c98065f63e91a31ea
https://pubmed.ncbi.nlm.nih.gov/18844300