Výsledky vyhledávání - "Marie-Edith Gourdel"

Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions

Autor: Marie-Edith Gourdel, Christophe Muller, Stéphane Bourg, Philippe Roche, Carine Derviaux, Olivier Sperandio, Bruno O. Villoutreix, David Lagorce, Xavier Morelli, Maria A. Miteva, Jean-Christophe Rain, Laurent Hoffer, Thomas W. Miller, Pascal Bonnet, Nicolas Bosc

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chem Biol

International audience; Protein-protein interactions (PPIs) mediate nearly every cellular process and represent attractive targets for modulating disease states but are challenging to target with small molecules. Despite this, several PPI inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c064c5ef5cfdd9725784bca1ddfacb1
https://hal.archives-ouvertes.fr/hal-02569625/document

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Protein-protein interaction inhibition (2P2I)-oriented chemical library accelerates hit discovery

Publikováno v: ACS Chemical Biology. 11(8)

Protein-protein interactions (PPIs) represent an enormous source of opportunity for therapeutic intervention. We and others have recently pinpointed key rules that will help in identifying the next generation of innovative drugs to tackle this challe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f76a7051d319e3863ed8afd303959c
http://ora.ox.ac.uk/objects/uuid:195f078f-0298-4ea2-8d67-8a21b856f859

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Approaches to the γ-lactone unit of CP-225,917 and CP-263,114

Autor: Alan Armstrong, Richard D. Kelsey, Trevor J. Critchley, Andrew A. Mortlock, Marie-Edith Gourdel-Martin

Publikováno v: Tetrahedron Letters. 43:6027-6030

Synthesis of the γ-lactone unit of CP-225,917 and CP-263,114 is reported by differentiation of a diester at C14 using either selective monohydrolysis or lactonisation of a C26-alcohol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c2606046de45eb69eac54608ea724e6
https://doi.org/10.1016/s0040-4039(02)01243-1

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Synthetic studies on CP-225,917 and CP-263,114: concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reactionElectronic supplementary information (ESI) available: crystal data for 13a. See http://www.rsc.org/suppdata/p1/b2/b202752f

Autor: Marie-Edith Gourdel-Martin, Richard D. Kelsey, Trevor J. Critchley, Andrew A. Mortlock, Alan Armstrong

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1344-1350

A concise synthesis of the bicyclo[4.3.1]dec-1(9)-en-10-one core of the natural products CP-225,917 and CP-263,114 is reported, employing an intramolecular Mukaiyama aldol cyclisation as a key step.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efe0a636fa2fd4bae6a99ddd18dcf873
https://doi.org/10.1039/b202752f

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