Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marie-Dominique Ah Kioon"'
Autor:
Thomas Funck-Brentano, Hilène Lin, Eric Hay, Marie-Dominique Ah Kioon, Corinne Schiltz, Didier Hannouche, Rémy Nizard, Frédéric Lioté, Philippe Orcel, Marie-Christine de Vernejoul, Martine Esther Cohen-Solal
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33543 (2012)
Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartil
Externí odkaz:
https://doaj.org/article/b68e486f5f0c498fafbe586b4f1950ed
Autor:
Chao Yang, Ruoxi Yuan, Bikash Mishra, Richard D. Bell, Yaxia Zhang, Yong Du, Marie Dominique Ah Kioon, Franck J. Barrat, Lionel B. Ivashkiv
The chemokine CXCL4 activates myeloid cells and contributes to the pathogenesis of inflammatory and fibrotic diseases. One mechanism of CXCL4 action is binding of nucleic acids to promote their internalization and activation of endosomal TLRs. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e50daffc3e36bae6263388d25bde300
https://doi.org/10.1101/2022.10.26.513860
https://doi.org/10.1101/2022.10.26.513860
Autor:
Vidyanath Chaudhary, Marie Dominique Ah Kioon, Sung-Min Hwang, Bikash Mishra, Kimberly Lakin, Kyriakos A. Kirou, Jeffrey Zhang-Sun, R. Luke Wiseman, Robert F. Spiera, Mary K. Crow, Jessica K. Gordon, Juan R. Cubillos-Ruiz, Franck J. Barrat
Publikováno v:
Journal of Experimental Medicine. 219
Plasmacytoid dendritic cells (pDCs) chronically produce type I interferon (IFN-I) in autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). We report that the IRE1α-XBP1 branch of the unfolded protein respons
Autor:
George Sukenick, Hao Fan, Quanju Zhao, Rong Wang, Marie Dominique Ah Kioon, J. David Warren, Yi Ban, Xiaoping Qing, Wenhu Zhan, Gang Lin, Xiaojing Ma, Carl Nathan, Pradeep K. Singh, Jane E. Salmon, Franck J. Barrat
Publikováno v:
J Med Chem
The immunoproteasome (i-20S) has emerged as a therapeutic target for autoimmune and inflammatory disorders and hematological malignancies. Inhibition of the chymotryptic β5i subunit of i-20S inhibits T cell activation, B cell proliferation, and dend
Autor:
Chao Yang, Mahesh Bachu, Yong Du, Caroline Brauner, Ruoxi Yuan, Marie Dominique Ah Kioon, Giancarlo Chesi, Franck J. Barrat, Lionel B. Ivashkiv
Publikováno v:
Nature communications. 13(1)
Regulation of endosomal Toll-like receptor (TLR) responses by the chemokine CXCL4 is implicated in inflammatory and fibrotic diseases, with CXCL4 proposed to potentiate TLR responses by binding to nucleic acid TLR ligands and facilitating their endos
Autor:
Yong Du, Marie Dominique Ah Kioon, Paoline Laurent, Vidyanath Chaudhary, Michael Pierides, Chao Yang, David Oliver, Lionel B. Ivashkiv, Franck J. Barrat
Publikováno v:
The Journal of experimental medicine. 219(7)
Chemokines control the migratory patterns and positioning of immune cells to organize immune responses to pathogens. However, many chemokines have been associated with systemic autoimmune diseases that have chronic IFN signatures. We report that a se
Autor:
Caroline Brauner, Yong Du, Lionel B. Ivashkiv, Giancarlo Chesi, Marie Dominique Ah Kioon, Mahesh Bachu, Franck J. Barrat, Chao Yang, Ruoxi Yuan
CXCL4 regulates responses of immune cells to endosomal TLRs and has been implicated in the pathogenesis of inflammatory and fibrotic diseases. However, mechanisms by which CXCL4 modulates TLR responses, and its functions in monocytes/macrophages, are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ac5cf8019d817af069195dd3aa4a80
https://doi.org/10.21203/rs.3.rs-945383/v1
https://doi.org/10.21203/rs.3.rs-945383/v1
Autor:
Hang-Korng Ea, Frédéric Lioté, Hilène Lin, Narjes Hafsia, Marie-Dominique Ah-Kioon, Frédéric Velard, Aurore Chatron-Colliet, Dominique Come, Martine Cohen-Solal
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10, ⟨10.1038/s41598-020-73924-1⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10, ⟨10.1038/s41598-020-73924-1⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Chondrocyte apoptosis may have a pivotal role in the development of osteoarthritis. Interest has increased in the use of anti-apoptotic compounds to protect against osteoarthritis development. In this work, we investigated the effect of adrenomedulli
Autor:
Marie Dominique Ah Kioon, Janice Chen, Franck J. Barrat, Christopher Brooks, Ross W. B. Lindsay, Robert Spiera, Jessica K. Gordon
Publikováno v:
Saturday, 15 June 2019.
Background Tagraxofusp is a novel targeted therapy directed to the interleukin-3 receptor (CD123). Tagraxofusp is comprised of human IL-3 recombinantly fused to a truncated diphtheria toxin (DT) payload engineered such that IL-3 replaces the native D
Autor:
Jessica K. Gordon, Claudio Tripodo, Mary K. Crow, David Fernandez, Kyriakos A. Kirou, Robert Spiera, Marie Dominique Ah Kioon, Franck J. Barrat
Publikováno v:
Sci Transl Med
Systemic sclerosis (SSc) is a multisystem life-threatening fibrosing disorder that lacks effective treatment. The link between the inflammation observed in organs such as the skin and profibrotic mechanisms is not well understood. The plasmacytoid de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de8a8589eec7c4ca09e8c6e48c9383f
https://europepmc.org/articles/PMC9865429/
https://europepmc.org/articles/PMC9865429/