Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse

Autor: Michèle Guerre-Millo, Lionel C. Clement, Hélène Poirier, Isabelle Niot, Marie-Claude Monnot, C. Rouault, Philippe Besnard

Publikováno v: Diabetologia
Diabetologia, Springer Verlag, 2005, 48 (6), pp.1059-1065. ⟨10.1007/s00125-005-1765-8⟩

International audience; Dietary supplementation with conjugated linoleic acids (CLA) has a fat-reducing effect in various species, but induces severe hyperinsulinaemia and hepatic steatosis in the mouse. This study aimed to determine the causes of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac76ede837aa311355ff400b6209cc97
https://doi.org/10.1007/s00125-005-1765-8

Differential involvement of peroxisome-proliferator-activated receptors α and δ in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine

Autor: Thierry Pineau, Claire Meunier-Durmort, Philippe Costet, Walter Wahli, Timothy M. Willson, Philippe Besnard, Olivier Braissant, Marie-Claude Monnot, Hélène Poirier, Isabelle Niot

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2001, 355 (2), pp.481-488. ⟨10.1042/bj3550481⟩

International audience; Liver fatty-acid-binding protein (L-FABP) is a cytoplasmic polypeptide that binds with strong affinity especially to long-chain fatty acids (LCFAs). It is highly expressed in both the liver and small intestine, where it is tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c671cf50e3f4c343406b18baf42b680
https://doi.org/10.1042/bj3550481

Luminal Lipid Regulates CD36 Levels and Downstream Signaling to Stimulate Chylomicron Synthesis

Autor: Maurice M.A.L. Pelsers, Marie Claude Monnot, Jan F. C. Glatz, Pascal Degrace, Fatiha Nassir, Valérie Petit, Philippe Besnard, Lionel C. Clement, Nada A. Abumrad, Hélène Poirier, Isabelle Niot, Thi Thu Trang Tran

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (28), pp.25201-25210. ⟨10.1074/jbc.M111.233551⟩
Journal of Biological Chemistry, 286(28), 25201-25210. American Society for Biochemistry and Molecular Biology, Inc.

International audience; The membrane glycoprotein CD36 binds nanomolar concentrations of long chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes. CD36 deficiency reduces chylomicron production through unknown mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36459141a7a1d9be7badcb46ca00c49f
https://hal-agrosup-dijon.archives-ouvertes.fr/hal-01915809

Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences

Autor: Marie-Claude Monnot, Jean-François Landrier, Jacques Grober, Charles Thomas, Philippe Besnard, Dany Gaillard, Anne Athias

Publikováno v: Gut
Gut, BMJ Publishing Group, 2006, 55, pp.1321-1331. 〈10.1136/gut.2005.085555〉
Gut, BMJ Publishing Group, 2006, 55, pp.1321-1331. ⟨10.1136/gut.2005.085555⟩

Background and aims: Faecal bile acid elimination greatly contributes to cholesterol homeostasis. Synthesised from cholesterol in the liver, bile acids are actively reclaimed in the ileum by the apical sodium dependent bile acid transporter (ASBT). A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704fb39b3b53cd972d7aeb21e7ec60b1
https://pubmed.ncbi.nlm.nih.gov/16484503

CD36 Displays Features of a Lipid-Sensor Involved in Chylomicron Processing in the Rodent Small Intestine

Autor: Thi Thu Trang Tran, M.A.L. Pelsers, Marie-Claude Monnot, Isabelle Niot, Pascal Degrace, Hélène Poirier, Philippe Besnard, V. Petit, Fatiha Nassir, Jan F. C. Glatz, Lionel C. Clement, Nada A. Abumrad

Publikováno v: ''Atherosclerosis Supplements''
''Atherosclerosis Supplements'', 2010, 11 (1), pp.82-83. ⟨10.1016/j.atherosclerosissup.2010.04.040⟩

International audience; The membrane glycoprotein CD36 binds nanomolar concentrations of long-chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes. CD36 deficiency reduces chylomicron production through unknown mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cbf04615318ab2de932ff35fe4eecf
https://doi.org/10.1016/j.atherosclerosissup.2010.04.040