Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Marie-Claude, Mathieu"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Autor:
Michel L. Trudeau, Vincent Gariépy, Marie-Claude Mathieu, R. Veillette, Daniel Clément, Jean-Christophe Daigle, Sylviane Rochon, Nicolas Delaporte, Gilles Lajoie, Pascale Chevallier, Manon Provencher, Karim Zaghib
Publikováno v:
Materials Advances. 1:854-872
In this paper, we report the surface modification of the Li4Ti5O12 (LTO) anode material with a freshly prepared Li-rich PTCLi4 organic molecule using a spray-dryer technique. In addition, burning the resulting powder yielded an electrode material wit
Autor:
Nicole Hustedt, Christian Gervais, Daniel Durocher, Henrique Melo, Bret D. Wallace, Michael Zinda, Marie-Claude Mathieu, Tejas Patel, C. Denise Appel, Ivan Muñoz, Silvia Emma Rossi, Alejandro Álvarez-Quilón, R. Scott Williams, Dheva Setiaputra, John Rouse, Jessica L. Wojtaszek, Yota Ohashi, Salomé Adam, Eric Grazzini, Tiffany Cho, Jordan T.F. Young
Publikováno v:
Mol Cell
The APEX2 gene encodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated BRCA1 or BRCA2, making APE2 a prime target for homologous recombination-defec
Autor:
Chisu Kim, Karim Zaghib, Wen Zhu, Michel L. Trudeau, Vincent Gariépy, Pierre Hovington, Manon Provencher, Daniel Clément, Ashok K. Vijh, Stéphanie Bessette, Catherine Gagnon, Marie-Claude Mathieu
Publikováno v:
Journal of The Electrochemical Society. 168:100526
Autor:
Abdelbast Guerfi, Marie-Claude Mathieu, Karim Zaghib, Henri Groult, Julie Trottier, Michel L. Trudeau, Alain Mauger, Pierre Hovington, Christian M. Julien
Publikováno v:
ECS Transactions. 50:103-108
We report the structure and morphology of the solid-solution series LiMnyFe1EyPO4 isomorphous with olivine synthesized by the hydrothermal route. Experimental studies include combined characterizations such as XRD, FTIR, SEM and HRTEM. Carbon-coated
LiMnyFe1-yPO4 (0.5≤y≤0.8) Cathode Materials Grown by Hydrothermal Route: Electrochemical Performance
Autor:
Abdelbast Guerfi, Julie Trottier, Karim Zaghib, Alain Mauger, Marie-Claude Mathieu, Christian M. Julien
Publikováno v:
ECS Transactions. 50:109-114
We report the electrochemical properties of LiMnyFe1-yPO4 (0.5≤y≤0.8) cathode materials synthesized by hydrothermal route. Special attention was taken to optimize the carbon deposit on the surface of particles in order to make easy comparison of
Autor:
Alex G. Therien, Carl Berthelette, Mark Wrona, Michael J. Boyd, Jean-François Lévesque, Rino Stocco, Daigen Xu, Yongxin Han, Danielle Denis, Steve Rowland, Marie-Claude Mathieu, John Colucci, Patsy Clark, Jean-François Chiasson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:484-487
A novel series of EP(4) ligands, based on a benzyl indoline scaffold, has been discovered. It was found that agonism and antagonism in this series can be easily modulated by minor modifications on the benzyl group. The pharmacokinetic, metabolic and
Autor:
Michael Arget, Virginie Bernier, Alex G. Therien, Christopher M. Tan, Karl Grenier, Deborah Slipetz, Gary P. O'Neill, Marie-Claude Mathieu, Rino Stocco, Michael A. Crackower, Joseph G. Joyce, Michael J. Bogusky, Christine Parachoniak
Publikováno v:
Journal of Biological Chemistry. 281:24704-24712
Neuropeptide S (NPS) and its receptor (NPSR) are thought to have a role in asthma pathogenesis; a number of single nucleotide polymorphisms within NPSR have been shown to be associated with an increased prevalance of asthma. One such single nucleotid
Autor:
Bruno Roy, Claudio Sturino, Nicolas Lachance, Robert Zamboni, Kathleen M. Metters, Christine Brideau, Lianhai Li, John Scheigetz, Danielle Denis, Deborah Slipetz, Marie-Claude Carrière, Elizabeth Cauchon, Gillian Greig, Gary P. O'Neill, Carl Berthelette, Michael J. Boyd, Marie-Claude Mathieu, Sonia Lamontagne, Nicole Sawyer, Robert N. Young, Nancy N. Tsou, Zhaoyin Wang, Stacia Kargman, Marc Labelle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3043-3048
A novel indole series of PGD2 receptor (DP receptor) antagonists is presented. Optimization of this series led to the identification of potent and selective DP receptor antagonists. In particular, antagonists 35 and 36 were identified with Ki values