Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marie-Clare St. Rose"'
Autor:
Joseph M. Ryan, Julia Svedova, Rebecca Abblett, Adam T. Hagymasi, Matthew P. Hanley, Anthony T. Vella, Steven L. Reiner, Marie-Clare St. Rose, Adam J. Adler, Payal Mittal, Archibald Agyekum-Yamoah
Publikováno v:
The Journal of Immunology. 200:1513-1526
Agonists to the TNF/TNFR costimulatory receptors CD134 (OX40) and CD137 (4-1BB) elicit antitumor immunity. Dual costimulation with anti-CD134 plus anti-CD137 is particularly potent because it programs cytotoxic potential in CD8+ and CD4+ T cells. Cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22b70b0a05fb1efe9cc0c68f5349239
https://doi.org/10.4049/jimmunol.1701039
https://doi.org/10.4049/jimmunol.1701039
Autor:
Roslyn A Taylor, Harry Z. Qui, Marie-Clare St. Rose, Anthony T. Vella, Adam T. Hagymasi, Adam J. Adler, Suman Bandyopadhyay
Publikováno v:
Immunology and cell biology
T cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies to the costimulatory receptors CD134 plus CD137 can program T cells responding to tolerogenic antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931139d8eb2e97d56de2b93795c02cc
https://doi.org/10.1038/icb.2012.74
https://doi.org/10.1038/icb.2012.74
Autor:
Adam T. Hagymasi, Marie-Clare St. Rose, Robert B. Clark, Adam J. Adler, Marianne A. Mihalyo, Harry Z. Qui, Suman Bandyopadhyay
Publikováno v:
The Journal of Immunology. 183:4975-4983
Cbl-b is an E3 ubiquitin ligase that limits Ag responsiveness in T cells by targeting TCR-inducible signaling molecules. Cbl-b deficiency thus renders T cells hyperresponsive to antigenic stimulation and predisposes individuals toward developing auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9e4a22ea81c20ca0fca664bb6b15100
https://doi.org/10.4049/jimmunol.0901243
https://doi.org/10.4049/jimmunol.0901243
Autor:
Xi Wang, Marie-Clare St. Rose, Joseph M. Ryan, Anthony T. Vella, Jeffrey S. Wasser, Payal Mittal, Adam J. Adler
The ability of immune-based cancer therapies to elicit beneficial CD8+ CTLs is limited by tolerance pathways that inactivate tumor-specific CD4 Th cells. A strategy to bypass this problem is to engage tumor-unrelated CD4 Th cells. Thus, CD4 T cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1958311f005f38fc893e5cf406be0661
https://europepmc.org/articles/PMC4670784/
https://europepmc.org/articles/PMC4670784/
Autor:
Dirk E. Smith, Anthony T. Vella, Antoine Ménoret, Soo Mun Ngoi, Adam J. Adler, Marie-Clare St. Rose, Michael G. Tovey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(26)
The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimmune disease. The mechanism by which a single adjuvant achieves two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821a149cf06c428cf839317268933519
https://pubmed.ncbi.nlm.nih.gov/22689946
https://pubmed.ncbi.nlm.nih.gov/22689946
Autor:
Adam T. Hagymasi, Suman Bandyopadhyay, Steven L. Reiner, Marie-Clare St. Rose, Robert S. Mittler, Scott M. Gordon, Anthony T. Vella, Raghunath Ramanarasimhaiah, Harry Z. Qui, Adam J. Adler, Antoine Ménoret
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(7)
Cytotoxic CD4 Th1 cells are emerging as a therapeutically useful T cell lineage that can effectively target tumors, but until now the pathways that govern their differentiation have been poorly understood. We demonstrate that CD134 (OX40) costimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e917cca011865f810a03dbc4c46d3ee
https://pubmed.ncbi.nlm.nih.gov/21880986
https://pubmed.ncbi.nlm.nih.gov/21880986
Publikováno v:
The Journal of Immunology. 194:69.6-69.6
Tumor escape following immune therapy can be caused by loss of specifically targeted MHC class I-restricted epitopes. It would thus be beneficial to develop therapies that engage multipronged anti-tumor responses. Agonist mAbs to the TNF/TNFR family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354a301b24b5c0db8bc4d77e533db8c2
https://doi.org/10.4049/jimmunol.194.supp.69.6
https://doi.org/10.4049/jimmunol.194.supp.69.6
Publikováno v:
The Journal of Immunology. 192:73.20-73.20
ST2, the receptor for the alarmin IL-33, is expressed on CD8 T cells and both IL-33 and ST2 can optimize anti-viral CD8 T cell immune responses. Further, signaling through ST2 in combination with innate-derived cytokines such as IL-12 can induce TCR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be079bd7431b1e2375e00c626796e290
https://doi.org/10.4049/jimmunol.192.supp.73.20
https://doi.org/10.4049/jimmunol.192.supp.73.20
Publikováno v:
The Journal of Immunology. 192:204.3-204.3
Tumor-specific cytotoxic CD8 T cell-based therapies can be efficacious in cancer patients. Nevertheless, disease progression often resumes due to outgrowth of antigen-loss variants (ALVs) that lack expression of the targeted MHC class I-restricted ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::546932b8780819c10792411b30f004c9
https://doi.org/10.4049/jimmunol.192.supp.204.3
https://doi.org/10.4049/jimmunol.192.supp.204.3
Publikováno v:
The Journal of Immunology. 192:115.13-115.13
IL-36 cytokines are members of the IL-1 family of cytokines. It has been reported that murine bone barrow-derived dendritic cells and CD4+ T lymphocytes constitutively express IL-36R and respond to IL-36. Also, during CD4+ T cell stimulation, inclusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10496fc8c673b81f0db7435339d3e6c3
https://doi.org/10.4049/jimmunol.192.supp.115.13
https://doi.org/10.4049/jimmunol.192.supp.115.13