Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Marie-Claire Peakman"'
Autor:
Kristin L. Rockwell, Paula M. Loria, Yue-Ming Wang, Marie-Claire Peakman, Andrea D. Weston, Claire M. Steppan, Regis Doyonnas, Fabien Vincent
Publikováno v:
Cell Chemical Biology. 27:1332-1346
The promise of phenotypic screening resides in its track record of novel biology and first-in-class therapies. However, challenges stemming from major differences between target-based and phenotypic screening do exist. These challenges prompted us to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b71b25d5a4f6efc33dabb4992b5aad
https://doi.org/10.1016/j.chembiol.2020.08.009
https://doi.org/10.1016/j.chembiol.2020.08.009
Autor:
James Edward John Mills, Robert E. Sharp, Joe Bradley, Jens Loesel, Marie-Claire Peakman, Christine Williams, David McLoughlin, Jeremy R. Everett, Hongyao Zhu, Andrew Simon Bell
Publikováno v:
Molecular Diversity
High-throughput screening (HTS) is an effective method for lead and probe discovery that is widely used in industry and academia to identify novel chemical matter and to initiate the drug discovery process. However, HTS can be time consuming and cost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798a29e297cfdead998ebd637c0930e5
http://hdl.handle.net/10044/1/56484
http://hdl.handle.net/10044/1/56484
Publikováno v:
Attrition in the Pharmaceutical Industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac407823a9458497303b4c8018c4abd
https://doi.org/10.1002/9781118819586.ch7
https://doi.org/10.1002/9781118819586.ch7
Autor:
Marie-Claire Peakman, Robert V. Stanton, Adam M. Gilbert, Regis Doyonnas, Karl Nocka, Linda Kitching, Paula M. Loria, Fabien Vincent, Thomas Schroeter, Claire M. Steppan, Marko Pregel
Publikováno v:
Science translational medicine. 7(293)
Phenotypic drug discovery approaches can positively affect the translation of preclinical findings to patients. However, not all phenotypic assays are created equal. A critical question then follows: What are the characteristics of the optimal assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3a59ecd1dd10428766c6e719453962
https://pubmed.ncbi.nlm.nih.gov/26109101
https://pubmed.ncbi.nlm.nih.gov/26109101
Autor:
Marie-Claire Peakman, Nancy Maizels
Publikováno v:
The Journal of Immunology. 161:4008-4015
B cells are activated for switch recombination by signals from Th cells, but the site at which this first occurs in vivo has yet to be identified. By in situ hybridization of splenic sections using riboprobes specific for the Iγ1 switch transcript a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e719077fa0c404b03db127ee049005cb
https://doi.org/10.4049/jimmunol.161.8.4008
https://doi.org/10.4049/jimmunol.161.8.4008
Autor:
Marie-Claire Peakman, Stephen J. Hill
Publikováno v:
European Journal of Pharmacology. 306:281-289
The effects of adenosine receptor-selective ligands on [3H]cyclic AMP accumulation have been investigated in type-1 and type-2 astrocyte-enriched cultures derived from neonatal rat forebrains. In type-1 astrocytes, 5'-N-ethylcarboxamidoadenosine (NEC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bf143a57a2b471a983ad11ed165c3e
https://doi.org/10.1016/0014-2999(96)00202-6
https://doi.org/10.1016/0014-2999(96)00202-6
Autor:
Stephen J. Hill, Marie-Claire Peakman
Publikováno v:
British Journal of Pharmacology. 115:801-810
1. The effects of adenosine A1 receptor stimulation on basal and histamine-stimulated levels of intracellular free calcium ion concentration ([Ca2+]i) have been investigated in primary astrocyte cultures derived from neonatal rat forebrains. 2. Hista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153503ae097be610315cf29cd4d15ee4
https://doi.org/10.1111/j.1476-5381.1995.tb15004.x
https://doi.org/10.1111/j.1476-5381.1995.tb15004.x
Autor:
Stephen J. Hill, Marie-Claire Peakman
Publikováno v:
British Journal of Pharmacology. 113:1554-1560
1. The effects of histamine receptor agonists and antagonists on phospholipid hydrolysis in rat-derived C6 glioma cells have been investigated. 2. Histamine H1 receptor-stimulation caused a concentration-dependent increase in the accumulation of tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6467d8d1e89283308d3b7e454b252d1
https://doi.org/10.1111/j.1476-5381.1994.tb17173.x
https://doi.org/10.1111/j.1476-5381.1994.tb17173.x
Autor:
Stephen J. Hill, Marie-Claire Peakman
Publikováno v:
British Journal of Pharmacology. 111:191-198
1. The effects of adenosine receptor agonists and antagonists on the accumulation of cyclic AMP have been investigated in primary cultures of rat astrocytes. 2. Adenosine A2-receptor stimulation caused a concentration-dependent increase in the accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0ca6655e7d2008e761e3c4ee671952
https://doi.org/10.1111/j.1476-5381.1994.tb14043.x
https://doi.org/10.1111/j.1476-5381.1994.tb14043.x
Autor:
Benjamin Reidich, Marie-Claire Peakman, Lorraine D. Shelly, Thomas Sand, Mary MacDougall, Yi Luo, George Chang, Xian-Cheng Jiang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 332(3)
Phospholipid transfer protein (PLTP) plays an important role in atherogenesis, and its function goes well beyond that of transferring phospholipids between lipoprotein particles. Previous studies showed that genetic deficiency of PLTP in mice causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5886939b0bf2c4ab527cec217cce2b
https://pubmed.ncbi.nlm.nih.gov/19933370
https://pubmed.ncbi.nlm.nih.gov/19933370