Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Marie-Christine Pardon"'
Autor:
Luís Costa-Marques, Katrin Arnold, Marie-Christine Pardon, Christiane Leovsky, Samantha Swarbrick, Claire Fabian, Alexandra Stolzing
Publikováno v:
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-11 (2019)
Abstract Background We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method BM-M were transplanted into the tail vein and the anim
Externí odkaz:
https://doaj.org/article/0fba1314393047d9b76aa97bcf5fce6e
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the development of tau
Externí odkaz:
https://doaj.org/article/fdad7f29f15742c29f5f79e979f67191
Autor:
Maria Yanez Lopez, Marie-Christine Pardon, Kerstin Baiker, Malcolm Prior, Ding Yuchun, Alessandra Agostini, Li Bai, Dorothee P Auer, Henryk M Faas
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212002 (2019)
Neuroinflammation plays an important role in the pathogenesis of a range of brain disorders. Non-invasive imaging of neuroinflammation is critical to help improve our understanding of the underlying disease mechanisms, monitor therapies and guide dru
Externí odkaz:
https://doaj.org/article/4647f125c46e4501a0c65495fb967395
Autor:
Othman Othman, Hayley Marshall, Mitchell Masterson, Poppy Winlow, Graham Gibson, Yuchun Ding, Marie-Christine Pardon
Publikováno v:
International Immunopharmacology. 117:109951
Publikováno v:
Behavioral Neuroscience. 134:82-100
A key characteristic of Alzheimer's disease (AD) is loss of episodic memory-memory for what happened, where and when; this final aspect-timing-is the focus of the present article. Although timing deficits have been reported in AD patients, few parall
Publikováno v:
Brain, Behavior, and Immunity
Highlights • Hippocampal metabolic profile of females is more pro-inflammatory and pro-oxidant. • Comparable LPS-induced sickness behaviour in male and female WT and APP/PS1 mice. • Pro- and anti-inflammatory pathways both recruited 4 h after s
Time or place? Dissociation between object-in-place and relative recency in young APPswe/PS1dE9 mice
Publikováno v:
Behavioral neuroscience. 135(1)
This study tests the predictions of a novel analysis of recognition memory based on a theory of associative learning, according to which recognition comprises two independent underlying processes, one relying on the to-be-recognized item having been
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the development of tau
Autor:
Marie-Christine Pardon
Publikováno v:
Expert Opinion on Biological Therapy. 18:165-169
The actin-sequestering thymosin beta4 (Tβ4) is the most abundant member of the β-thymosins, and is widely expressed in the central nervous system (CNS), but its functions in the healthy and diseased brain are poorly understood. The expression of T
Autor:
Marie-Christine Pardon
Publikováno v:
Dose-Response, Vol 8 (2010)
The aging of the population brings new heath challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension
Externí odkaz:
https://doaj.org/article/d5b0527b76fd4e75abf2c03cf7270bfe