Výsledky vyhledávání - "Marie-Christine Gerbod"

Involvement of caveolin-1 and CD36 in native LDL endocytosis by endothelial cells

Autor: Olivier Lambert, Grégoire Naudin, Sylvie Poussard, Annelise Sahin, Laurence Dallet, Marion Decossas, Marie-Christine Gerbod-Giannone

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2019, 1863 (5), pp.830-838. ⟨10.1016/j.bbagen.2019.01.005⟩

International audience; Atherosclerosis is a lipid disease characterized by accumulation of low density lipoprotein (LDL) in the artery wall. The transport of LDL across the endothelium of coronary artery is an initiating event of atherosclerosis, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95a898e0f920ff0ae9c6b830abc2a05
https://hal.archives-ouvertes.fr/hal-02346733/file/cbmn_BBA_gerbod_2019.pdf

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Visualization of adherent cell monolayers by cryo-electron microscopy: A snapshot of endothelial adherens junctions

Autor: Olivier Lambert, Etienne Gontier, Olivier Le Bihan, Marion Decossas, Marie-Christine Gerbod-Giannone

Publikováno v: Journal of structural biology 192(3), 470-477 (2015). doi:10.1016/j.jsb.2015.10.009

Cryo-electron microscopy (cryo-EM) allows the visualization of the cell architecture in its native state. We developed a robust solution to adapt cryo-electron microscopy of vitreous sections (CEMOVIS) to a monolayer of adherent cells using a functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b687442e62a8d21288fcd7a40a7865f
http://hdl.handle.net/20.500.12278/10964

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Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor

Autor: Ira Tabas, Dongying Cui, Heather Seitz, Yankun Li, Marie Christine Gerbod-Giannone, Alan R. Tall, Glenn K. Matsushima, Edward B. Thorp

Publikováno v: Journal of Biological Chemistry. 281:6707-6717

Macrophage apoptosis and the ability of phagocytes to clear these apoptotic cells are important processes in advanced atherosclerosis. Phagocytic clearance not only disposes of dead cells but usually elicits an anti-inflammatory response. To study th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477efd7a3adb5d2cfa1f59b603094134
https://doi.org/10.1074/jbc.m510579200

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TNF alpha induces ABCA1 through NF-kappa B in macrophages and in phagocytes ingesting apoptotic cells

Autor: Seongah Han, Marie-Christine Gerbod-Giannone, Li-Chung Hsu, Adriaan G. Holleboom, Ira Tabas, Yankun Li, Alan R. Tall

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 103(9), 3112-3117. National Academy of Sciences

Recent evidence suggests that tumor necrosis factor alpha (TNF alpha) signaling in vascular cells can have antiatherogenic consequences, but the mechanisms are poorly understood. TNFa is released by free cholesterol loaded apoptotic macrophages, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f075cfc869ae65868063da822a63a4
https://doi.org/10.1073/pnas.0510345103

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Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

Autor: Yankun Li, Marie-Christine Gerbod-Giannone, Robert F. Schwabe, Richard A. Flavell, Alan R. Tall, David A. Brenner, Ira Tabas, Tracie DeVries-Seimon, Pin Mei Yao, Roger J. Davis

Publikováno v: Journal of Biological Chemistry. 280:21763-21772

Two key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular occlusion (“vulnerable plaques”) are abundant inflammatory mediators and macrophages with excess unesterified, or “free,” cholesterol (FC). Herein we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceff1964b39702d9d44112fcd05235bb
https://doi.org/10.1074/jbc.m501759200

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Suppression of Cholesterol 7α-Hydroxylase Transcription and Bile Acid Synthesis by an α1-Antitrypsin Peptide via Interaction with α1-Fetoprotein Transcription Factor

Autor: Gregorio Gil, Sabina Janciauskiene, Antonio del Castillo-Olivares, Phillip B. Hylemon, Marie-Christine Gerbod-Giannone

Publikováno v: Journal of Biological Chemistry. 277:42973-42980

alpha1-Antitrypsin (alpha1-AT) is a serum protease inhibitor that is synthesized mainly in the liver, and its rate of synthesis markedly increases in response to inflammation. This increase in alpha1-AT synthesis results in an increase in peptides, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4cb60b47ff71ac8801a4528bb74f50
https://doi.org/10.1074/jbc.m205089200

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Divergent and common groups of proteins in glands of venomous snakes

Autor: Vincent Rioux, André Ménez, Marie-Christine Gerbod, Andrzej Galat, Françoise Bouet

Publikováno v: Electrophoresis. 19:788-796

Protein contents of venom-producing glands from the sea-snake Laticauda colubrina (LC) and terrestrial Vipera Russelli (VR) were studied using high-resolution two-dimensional gels: isoelectric focusing followed by sodium dodecyl sulfate-polyacrylamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28da69fab06ab279fbfafbbe97295372
https://doi.org/10.1002/elps.1150190531

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Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

Autor: Yankun, Li, Robert F, Schwabe, Tracie, DeVries-Seimon, Pin Mei, Yao, Marie-Christine, Gerbod-Giannone, Alan R, Tall, Roger J, Davis, Richard, Flavell, David A, Brenner, Ira, Tabas

Publikováno v: The Journal of biological chemistry. 280(23)

Two key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular occlusion ("vulnerable plaques") are abundant inflammatory mediators and macrophages with excess unesterified, or "free," cholesterol (FC). Herein we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a83eed85d248037cfdf25bb7cd7e4e3
https://pubmed.ncbi.nlm.nih.gov/15826936

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Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

Autor: Lorraine J. Gudas, Erik G. Lund, Marie Christine Gerbod-Giannone, Philippe Costet, Xuan Fu, Florent Lalanne, Alan R. Tall, Jennifer R. Molina

ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors. Retinoic acid receptor (RAR) activators (all-trans-retinoic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7809decd4b5ae9534ff99d9a8ef2e6
https://europepmc.org/articles/PMC207565/

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ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

Autor: Wengen Chen, Andreas W. Jehle, Laurent O. Martinez, Alan R. Tall, Marie Christine Gerbod-Giannone, Patrick Linsel-Nitschke, Debin Lan, Nan Wang

Publikováno v: The Journal of biological chemistry. 278(44)

ATP-binding cassette transporter 1 (ABCA1), the defective transporter in Tangier disease, binds and promotes cellular cholesterol and phospholipid efflux to apolipoprotein I (apoA-I). Based on a high degree of sequence homology between ABCA1 and ABCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffb06a78e2bcd7bf3e27fc5fd97211f
https://pubmed.ncbi.nlm.nih.gov/12917409

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