Výsledky vyhledávání - "Marie-Christine Ailhaud"

Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model

Autor: Stéphanie Tardif, Amélie Tourette, David Troulier, Antoine Dumoulin, Marie‐Thérèse Calmettes, Delphine Denais-Lalieve, Marie-Christine Ailhaud, Claudie Cathala, Luc De Vries, Isabelle Rauly-Lestienne, Anne-Dominique Degryse, Emilie Lauressergues, Didier Cussac, Fabrice Lestienne, Peter Heusler

Publikováno v: Pharmacology Research & Perspectives

The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The recently approved orally active drugs vismodegib (GDC‐0449) and sonidegib (LDE–225) were not only efficacious for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58dcc34913644c8ac672599699b2397
https://pubmed.ncbi.nlm.nih.gov/27069629

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Competitive interaction of 5-HT(1A) receptors with G-protein subtypes in CHO cells demonstrated by RNA interference

Autor: Johan Binesse, Didier Cussac, Marie-Christine Ailhaud, Isabelle Rauly-Lestienne, Fabrice Lestienne, Adrian Newman-Tancredi

Publikováno v: Cellular signalling. 23(1)

Following agonist action, G-protein-coupled receptors may exhibit differential coupling to G-proteins or second messenger pathways, supporting the notion of agonist-directed trafficking. To explore these mechanisms, we have designed and transfected s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8bf0795e1a389f2372a1db16af1522
https://pubmed.ncbi.nlm.nih.gov/20727408

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Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human alpha2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an alpha2B subtype preferential agonist

Autor: Peter Heusler, Guillaume Croville, Amélie Tourette, Isabelle Rauly-Lestienne, Marie-Christine Ailhaud, Didier Cussac, Stéphanie Tardif

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 2010, 640 (1-3), pp.8-14. ⟨10.1016/j.ejphar.2010.04.034⟩

8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)tetralin] is the prototypical agonist at serotonin 5-HT1A receptors; however, activity at other targets contributes to the functional effects of the compound as well. We examined the properties of 8-OH-DPAT an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6aca20b127512fb3fb0d8a1327f06b
https://pubmed.ncbi.nlm.nih.gov/20450907

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Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

Autor: Marie-Christine Ailhaud, Jean-Claude Martel, Nathalie Danty, Didier Cussac, Adrian Newman-Tancredi, Elisa Boutet-Robinet, Isabelle Rauly-Lestienne

Publikováno v: European journal of pharmacology. 594(1-3)

Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a series of chemically di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60b34407f58d09a82af935e7f7e5cb8
https://pubmed.ncbi.nlm.nih.gov/18703043

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Activation of G proteins and extracellular signal-regulated kinase 1/2 phosphorylation via human dopamine D4.4 receptors: differential pathway-dependent potencies of receptor agonists

Autor: Peter Heusler, Christiane Palmier, Stéphanie Tardif, Didier Cussac, Liesbeth A. Bruins Slot, Marie-Christine Ailhaud, Isabelle Rauly-Lestienne, Amélie Tourette

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 379(1)

Agonist activity at recombinant human dopamine D4.4 receptors was compared in stably transfected CHO cells using two functional readouts: G protein activation by [35S]GTPgammaS binding and phosphorylation of extracellular signal-regulated kinase 1/2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e28e94335884807c397c1889d460685
https://pubmed.ncbi.nlm.nih.gov/18682919

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Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties

Autor: Elisa Boutet-Robinet, Didier Cussac, Marie-Christine Ailhaud, Isabelle Rauly-Lestienne, Adrian Newman-Tancredi

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 376(1-2)

5-HT(7) receptors are present in thalamus and limbic structures, and a possible role of these receptors in the pathology of schizophrenia has been evoked. In this study, we examined binding affinity and agonist/antagonist/inverse agonist properties a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ac66ca256e7ccfe19c611a21c493f5
https://pubmed.ncbi.nlm.nih.gov/17786406

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alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway

Autor: Thierry Wurch, Petrus J. Pauwels, Isabelle Rauly, Marie-Christine Ailhaud

Publikováno v: Biochemical pharmacology. 59(12)

Fusion proteins were constructed between a recombinant human alpha(2A)-adrenoceptor and either a rat wild-type G(alphai1) or putative pertussis toxin-resistant form of the G(alphai1) protein (G(alphai1)Cys(351)Gly). [(3)H]2-[2-(2-Methoxy-1, 4-benzodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaae62a9aa1fb98c0de52dcd9b5dbf57
https://pubmed.ncbi.nlm.nih.gov/10799649

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