Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marie-Chantal Grégoire"'
Autor:
Frédéric Leduc, David Faucher, Geneviève Bikond Nkoma, Marie-Chantal Grégoire, Mélina Arguin, Raymund J Wellinger, Guylain Boissonneault
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17353 (2011)
Determination of cellular DNA damage has so far been limited to global assessment of genome integrity whereas nucleotide-level mapping has been restricted to specific loci by the use of specific primers. Therefore, only limited DNA sequences can be s
Externí odkaz:
https://doaj.org/article/105b9a1ded0c47aabc94ce1421369cc4
Autor:
Pierre-Étienne Jacques, Martin V. Richter, Marie-Chantal Grégoire, Tiphanie Cavé, Mélina Arguin, Guylain Boissonneault, Frédéric Leduc, Martin Morin
Publikováno v:
Cellular and Molecular Life Sciences. 75:2859-2872
De novo germline mutations arise preferentially in male owing to fundamental differences between spermatogenesis and oogenesis. Post-meiotic chromatin remodeling in spermatids results in the elimination of most of the nucleosomal supercoiling and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecde4a825e9c3bdb58ae4d3670b83a4e
https://doi.org/10.1007/s00018-018-2769-0
https://doi.org/10.1007/s00018-018-2769-0
Autor:
Mélina Arguin, Julien Massonneau, Marie-Chantal Grégoire, Marc-André Brazeau, Guylain Boissonneault, Frédéric Leduc
Publikováno v:
DNA Repair. 48:63-68
DNA double-strand breaks (DSBs) represent a major threat to the genetic integrity of the cell. Knowing both their genome-wide distribution and number is important for a better assessment of genotoxicity at a molecular level. Available methods may hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5660687d77b4711573c87f60f76d924
https://doi.org/10.1016/j.dnarep.2016.10.005
https://doi.org/10.1016/j.dnarep.2016.10.005
Publikováno v:
A Clinician's Guide to Sperm DNA and Chromatin Damage ISBN: 9783319718149
The histone-to-protamine exchange process in spermatids (chromatin remodeling) offers a window for DNA vulnerability whereby both endogenous and exogenous factors can induce damage. Transient DNA strand breaks have been shown to be part of the differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::723766a0d5f2c6288502357a0573cf4a
https://doi.org/10.1007/978-3-319-71815-6_13
https://doi.org/10.1007/978-3-319-71815-6_13
Publikováno v:
The international journal of biochemistrycell biology. 98
In mammals, spermiogenesis is characterized by transient formation of DNA double-strand breaks (DSBs) in the whole population of haploid spermatids. DSB repair in such haploid context may represent a mutational transition. Using a combination of puls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66313db3003810c2d797f5de043e50d3
https://pubmed.ncbi.nlm.nih.gov/29474927
https://pubmed.ncbi.nlm.nih.gov/29474927
Autor:
Régen Drouin, Aimé Ntwari, Francis Hemmings, Triantafyllos Tafas, Macoura Gadji, Josée Lamoureux, Michael W. Kilpatrick, Seemi Ayub, Kada Krabchi, Ahmed Emad, Marie-Chantal Grégoire, Oumar Samassekou
Publikováno v:
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology
Fluorescencein situhybridization (FISH) and manual scanning is a widely used strategy for retrieving rare cellular events such as fetal cells in maternal blood. In order to determine the efficiency of these techniques in detection of rare cells, slid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb810fc44fcba768a4691578ff6d365
https://doi.org/10.1155/2012/610856
https://doi.org/10.1155/2012/610856
Autor:
Martin V. Richter, Frédéric Leduc, Mélina Arguin, Olivier Simard, Marc-André Brazeau, Marie-Chantal Grégoire, Geneviève Acteau, Guylain Boissonneault, Isabelle Marois
Publikováno v:
Journal of Visualized Experiments.
The differentiation of mouse spermatids is one critical process for the production of a functional male gamete with an intact genome to be transmitted to the next generation. So far, molecular studies of this morphological transition have been hamper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203f69f113f93a392665254a82b77183
https://doi.org/10.3791/53379-v
https://doi.org/10.3791/53379-v
Autor:
Annie D’AmoursA. D’Amours, Antonio Conconi, Frédéric Leduc, Guylain Boissonneault, François Peyresaubes, Marie-Chantal Grégoire
Publikováno v:
DNA repair. 36
A strategy amenable to the genome-wide study of DNA damage and repair kinetics is described. The ultraviolet damage endonuclease (UVDE) generates 3'-OH ends at the two major UV induced DNA lesions, cyclobutane pyrimidine dimers (CPDs) and 6,4 pyrimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe3abd3cdc3ad00d0b3ade015f1c94e
https://pubmed.ncbi.nlm.nih.gov/26547444
https://pubmed.ncbi.nlm.nih.gov/26547444
Autor:
Frédéric Leduc, Marc-André Brazeau, Olivier Simard, Martin V. Richter, Mélina Arguin, Guylain Boissonneault, Isabelle Marois, Marie-Chantal Grégoire
Publikováno v:
Human Mutation.
Transient DNA breaks and evidence of DNA damage response have recently been reported during the chromatin remodeling process in haploid spermatids, creating a potential window of enhanced genetic instability. We used flow cytometry to achieve separat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2f4e77172833bded169497ef25363d
https://doi.org/10.1002/humu.22637
https://doi.org/10.1002/humu.22637
Autor:
Marc-André Brazeau, Olivier Simard, Anne Gouraud, Mélina Arguin, Julien Massonneau, Marie-Chantal Grégoire, Guylain Boissonneault
Publikováno v:
Basic and Clinical Andrology
During the haploid phase of spermatogenesis, spermatids undergo a complex remodeling of the paternal genome involving the finely orchestrated replacement of histones by the highly-basic protamines. The associated striking change in DNA topology is ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743f303755fe877816b6e899667a64d2
https://doi.org/10.1186/2051-4190-23-11
https://doi.org/10.1186/2051-4190-23-11