Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marie-Camille Rowell"'
Autor:
Stéphane Lopes-Paciencia, Véronique Bourdeau, Marie-Camille Rowell, Davoud Amirimehr, Jordan Guillon, Paloma Kalegari, Arnab Barua, Vincent Quoc-Huy Trinh, Feryel Azzi, Simon Turcotte, Adrian Serohijos, Gerardo Ferbeyre
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114044- (2024)
Summary: We identify a senescence restriction point (SeRP) as a critical event for cells to commit to senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a memory of previous stresses, and combines oncogenic signals
Externí odkaz:
https://doaj.org/article/991cc27b36934f9e9ca9610edd8935ba
Autor:
Audrey Hébert, Maxime Parisotto, Marie-Camille Rowell, Alexandra Doré, Ana Fernandez Ruiz, Guillaume Lefrançois, Paloma Kalegari, Gerardo Ferbeyre, Andreea R. Schmitzer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells. We first present their in vitro and membrane activity, before we address their mecha
Externí odkaz:
https://doaj.org/article/6a200413183b471cb0be937679e2ef46
Autor:
Gerardo Ferbeyre, Frédéric Lessard, Subburaj Ilangumaran, Marie-Camille Rowell, Véronique Bourdeau, Viviane Calabrese, Karine Moineau-Vallée, Mariana Acevedo, Geneviève Huot, Lian Mignacca, Emmanuelle Saint-Germain
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. Paradoxically, SOCS1 is also overexpressed in many human cancers. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c32dad5852852b3d66ab965c8d549e
https://doi.org/10.1158/0008-5472.c.6510758
https://doi.org/10.1158/0008-5472.c.6510758
Autor:
Maxime Parisotto, Nhung Vuong-Robillard, Paloma Kalegari, Thulaj Meharwade, Loick Joumier, Sebastian Igelmann, Véronique Bourdeau, Marie-Camille Rowell, Michael Pollak, Mohan Malleshaiah, Andréea Schmitzer, Gerardo Ferbeyre
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5597
Pancreatic cancer (pancreatic ductal adenocarcinoma: PDAC) is one of the most aggressive neoplastic diseases. Metformin use has been associated with reduced pancreatic cancer incidence and better survival in diabetics. Metformin has been shown to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d22ed0bb82015d36690eddfbb0e8e43
Autor:
Gerardo Ferbeyre, Paloma Kalegari, Lian Mignacca, Frédéric Lessard, Jan Pencik, Geneviève Huot, Jordan Quenneville, Marie-Camille Rowell, Laura Hulea, Jacob Bouchard, Stéphane Lopes-Paciencia, Michael Pollak, Oro Uchenunu, Ana Fernandez-Ruiz, Katja Julissa Ponce, Etienne Gagnon, Nhung Vuong, Véronique Bourdeau, Mehdi Benfdil, Haytham M. Wahba, Ivan Topisitrovic, James G. Omichinski, Richard Moriggl, Antonio Nanci, Sebastian Igelmann, Aurélien Fouillen, David Papadopoli, Lukas Kenner
Publikováno v:
SSRN Electronic Journal.
Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a novel multi-enzymatic complex that reprograms NAD metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ba7a35c7f68a80a84e12eade3c594f
https://doi.org/10.2139/ssrn.3753808
https://doi.org/10.2139/ssrn.3753808
Autor:
Xavier Deschênes-Simard, Marlene Oeffinger, Cornelia E. Zorca, Sebastian Igelmann, Léa Brakier-Gingras, Daniel Zenklusen, Emmanuelle Saint-Germain, Olga Moiseeva, Geneviève Huot, Neylen Del Toro, Lian Mignacca, Benjamin Le Calvé, Marinieve Montero, Marie-Camille Rowell, Frédéric Lessard, Véronique Bourdeau, Gerardo Ferbeyre, Christian Trahan, Marina Bury, Stéphane Lopes-Paciencia
Publikováno v:
Nature Cell Biology. 20:789-799
Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73568848198ad7a458ebe043b524f17e
https://doi.org/10.1038/s41556-018-0127-y
https://doi.org/10.1038/s41556-018-0127-y
Publikováno v:
Aging (Albany NY)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c2ebe2042a7d2a5f9654539854c35
https://doi.org/10.18632/aging.102622
https://doi.org/10.18632/aging.102622
Autor:
Oro Uchenunu, Gerardo Ferbeyre, James G. Omichinski, Paloma Kalegari, David Papadopoli, Antonio Nanci, Ivan Topisirovic, Jordan Quenneville, Sebastian Igelmann, Laura Hulea, Aurélien Fouillen, Lukas Kenner, Jordan Guillon, Véronique Bourdeau, Haytham M. Wahba, Jacob Bouchard, Etienne Gagnon, Richard Moriggl, Mehdi Benfdil, Jan Pencik, Marie-Camille Rowell, Katia Julissa Ponce, Frédéric Lessard, Lian Mignacca, Stéphane Lopes-Paciencia, Michael Pollak, Ana Fernandez-Ruiz, Geneviève Huot, Nhung Vuong
Publikováno v:
Molecular Cell. 81:3848-3865.e19
Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex that reprograms NAD metabolism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd9ac33bfd391617e3ed4d32b35759f
https://doi.org/10.1016/j.molcel.2021.08.028
https://doi.org/10.1016/j.molcel.2021.08.028
Autor:
Ana Fernandez Ruiz, Maxime Parisotto, Gerardo Ferbeyre, Audrey Hébert, Paloma Kalegari, Andreea R. Schmitzer, Guillaume Lefrancois, Marie-Camille Rowell, Alexandra Doré
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth/viability of pancreatic cancer cells. We first present their in vitro and membrane activity, before we address their mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d854daacf9d8b0e22ae6a7bbbb76174
Autor:
Gerardo Ferbeyre, Paloma Kalegari, Léa Brakier-Gingras, Emmanuelle Saint-Germain, Sebastian Igelmann, Mehdi Benfdil, Lian Mignacca, Véronique Bourdeau, Marie-Camille Rowell, Neylen Del Toro, Ana Fernandez-Ruiz, Frédéric Lessard, Stéphane Lopes-Paciencia
Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba23de22e1eda67ba431f1b1cd846602
https://europepmc.org/articles/PMC6464582/
https://europepmc.org/articles/PMC6464582/