Výsledky vyhledávání - "Marie-Aude Cheminant"

Akademický článek

GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma

Autor: Martin Klein, Eleonore Dijoux, Marie-Aude Cheminant, Laurent Intes, Grégory Bouchaud

Publikováno v: Frontiers in Allergy, Vol 4 (2023)

BackgroundAsthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen

Externí odkaz: https://doaj.org/article/026da0d889f14ae3ac124484f4a8c24b

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Akademický článek

The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse

Autor: Antoine Moui, Martin Klein, Dorian Hassoun, Eléonore Dijoux, Marie-Aude Cheminant, Antoine Magnan, Grégory Bouchaud

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)

Abstract Background Interleukin 15 (IL-15) is a growth and modulating factor for B, T lymphocytes and natural killer cells (NK). Its action on innate and adaptive immunity is modulated by its alpha chain receptor (IL-15Rα). The IL-15/sIL-15Rα compl

Externí odkaz: https://doaj.org/article/083ab576a77a4fc39c35f105a880adfb

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Akademický článek

Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization

Autor: Martin Klein, Luc Colas, Marie-Aude Cheminant, Carole Brosseau, Vincent Sauzeau, Antoine Magnan, Grégory Bouchaud

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by mo

Externí odkaz: https://doaj.org/article/439c9b1e367b42d887ab9ebbffacf4e5

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Akademický článek

CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients

Autor: Carole Brosseau, Maxim Durand, Luc Colas, Eugénie Durand, Aurore Foureau, Marie-Aude Cheminant, Gregory Bouchaud, Laure Castan, Martin Klein, Antoine Magnan, Sophie Brouard

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

CD9 was recently identified as a marker of murine IL-10-competent regulatory B cells. Functional impairments or defects in CD9+ IL-10-secreting regulatory B cells are associated with enhanced asthma-like inflammation and airway hyperresponsiveness. I

Externí odkaz: https://doaj.org/article/276dfed2b91a419baf2d295b7fc51ba1

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Akademický článek

Block copolymer/DNA vaccination induces a strong allergen-specific local response in a mouse model of house dust mite asthma.

Autor: Camille Rolland-Debord, David Lair, Tiphaine Roussey-Bihouée, Dorian Hassoun, Justine Evrard, Marie-Aude Cheminant, Julie Chesné, Faouzi Braza, Guillaume Mahay, Vincent Portero, Christine Sagan, Bruno Pitard, Antoine Magnan

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85976 (2014)

BackgroundAllergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f) is a common species. Currently, immunotherapy is based on allergen administration, which has vari

Externí odkaz: https://doaj.org/article/6b1f31557e3143d0a1b8ff42dd6b6c3e

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Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma

Autor: Eléonore Dijoux, Martin Klein, Barbara Misme-Aucouturier, Marie-Aude Cheminant, Marion de Carvalho, Louise Collin, Dorian Hassoun, Erwan Delage, Mathilde Gourdel, Gervaise Loirand, Vincent Sauzeau, Antoine Magnan, Grégory Bouchaud

Publikováno v: Allergy, Asthma & Immunology Research
Allergy, Asthma & Immunology Research, 2023, 15 (2), pp.e9. ⟨10.4168/aair.2023.15.e9⟩

International audience; Purpose. Asthma is a frequent chronic inflammatory bronchial disease affecting more than 300 million patients worldwide, 70% of whom are secondary to allergy. The diversity of asthmatic endotypes contributes to their complexit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74211e990c5f22ea04040d6f4778c5a
https://hal.inrae.fr/hal-03953921/document

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Targeting the interleukin‐7 receptor alpha by an anti‐CD127 monoclonal antibody improves allergic airway inflammation in mice

Autor: Hoa Le Mai, Grégory Bouchaud, Thi Van Ha Nguyen, Antoine Magnan, Marie-Aude Cheminant, Kelly Henrio, Sophie Brouard

Publikováno v: Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, 2020, Online ahead of print. ⟨10.1111/cea.13665⟩
Clinical and Experimental Allergy, 2020, Online ahead of print. ⟨10.1111/cea.13665⟩

International audience; Background: Interleukin-7 (IL-7) is the most important cytokine for T cell homeostasis. IL-7 signals through the IL-7 receptor (IL-7R) which is composed of an alpha chain (IL-7Rα), also called CD127 and a common gamma chain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ea31cfa3dd5d17da202e4adcf6b42
https://doi.org/10.1111/cea.13665

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Engineering a safe monoclonal anti‐human IL‐2 that is effective in a murine model of food allergy and asthma

Autor: Marie-Aude Cheminant, Marie Wauters, Grégory Bouchaud, Marion De Carvalho, Barbara Misme-Aucouturier, Antoine Magnan, Olivier Tranquet, Martin Klein

Publikováno v: Allergy
Allergy, Wiley, 2021, pp.Early Access. ⟨10.1111/all.15029⟩

International audience; Background Regulatory T cells (Tregs) are known to protect against allergies. Moreover, the decrease in the frequency and efficiency of Tregs amplifies allergic symptoms. Aim This study investigated whether expanding Tregs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3162728780402cb5dfb5b160ff6e9f
https://hal.inrae.fr/hal-03351280

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Der p 2-derived peptide abrogates HDM-induced allergic asthma in mouse and humanized model

Autor: Antoine Magnan, Martin Klein, Marie-Aude Cheminant, Grégory Bouchaud

Publikováno v: ERS International Congress 2019 abstracts
ERS International Congress 2019 abstracts, Sep 2019, Madrid, France. pp.PA4364, ⟨10.1183/13993003.congress-2019.PA4364⟩

International audience; Background: The Dermatophagoides pteronyssinus allergen, Der p 2, is recognized by more than 90% of HDM-allergic patients and induce asthma. Among these patients, 5 to 10 % remain uncontrolled and need innovative approaches ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f87cdb2ffe80f6af2296c383315fed
https://hal.inrae.fr/hal-02913006

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A regulatory CD9+B-cell subset inhibits HDM-induced allergic airway inflammation

Autor: Marie-Aude Cheminant, Julie Chesné, S. Dirou, Sophie Brouard, Guillaume Mahay, Faouzi Braza, Carole Brosseau, Maxim Durand, Antoine Magnan

Publikováno v: Allergy
Allergy, Wiley, 2015, Equipe 6, 70 (11), pp.1421--1431. ⟨10.1111/all.12697⟩

Background Exposure to respiratory allergens triggers airway hyperresponsiveness and inflammation characterized by the expansion of TH2 cells and the production of allergen specific IgE. Allergic asthma is characterized by an alteration in immune reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15db7550c22c99b38b7fc2eb69daf467
https://doi.org/10.1111/all.12697

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