PICALM and Alzheimer’s Disease: An Update and Perspectives

Autor: Kunie Ando, Siranjeevi Nagaraj, Fahri Küçükali, Marie-Ange de Fisenne, Andreea-Claudia Kosa, Emilie Doeraene, Lidia Lopez Gutierrez, Jean-Pierre Brion, Karelle Leroy

Publikováno v: Cells, Vol 11, Iss 24, p 3994 (2022)

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus after APOE and BIN1. PICALM is a clathrin-adaptor protein that plays

Externí odkaz: https://doaj.org/article/f918cd0341824cfe89038a7f5b0d2b92

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

Autor: Kunie Ando, Sarah Houben, Mégane Homa, Marie-Ange de Fisenne, Marie-Claude Potier, Christophe Erneux, Jean-Pierre Brion, Karelle Leroy

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2021)

Externí odkaz: https://doaj.org/article/ee704f4fb63f4baf80bc98b7011b3810

Picalm reduction exacerbates tau pathology in a murine tauopathy model

Autor: Kristel Sleegers, Salwa Mansour, Sarah Houben, Jean Pierre Brion, Marie-Claude Potier, Toshio Watanabe, Charles Duyckaerts, Karelle Leroy, Marie-Ange De Fisenne, Zehra Yilmaz, Cristina Vergara, Kunie Ando, Robert De Decker, Luc Buée, Valérie Suain

Publikováno v: Acta neuropathologica
Acta Neuropathologica, 139 (4

Genome-wide association studies (GWAS) have identified PICALM as one of the most significant susceptibility loci for late-onset Alzheimer's disease (AD) after APOE and BIN1. PICALM is a clathrin-adaptor protein and plays critical roles in clathrin-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b1ced617d0454727a7a6221cea8d8b
https://doi.org/10.1007/s00401-020-02125-x

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

Autor: Jean Pierre Brion, Christophe Erneux, Marie-Ange De Fisenne, Marie-Claude Potier, Sarah Houben, Mégane Homa, Kunie Ando, Karelle Leroy

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Frontiers Media, 2021, 13, ⟨10.3389/fnmol.2020.583755⟩
Frontiers in Molecular Neuroscience, 13
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Frontiers in Molecular Neuroscience, 2021, 13, ⟨10.3389/fnmol.2020.583755⟩

International audience; Alzheimer’s disease (AD) is the most common form of dementia. Its prevalence will significantlyincrease in the coming decades, whereas no efficient treatment is currently available. AD hastwo main neuropathological lesions:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580ef5bb92810cd4a4467a7afa75835e
https://hal.sorbonne-universite.fr/hal-03136084