Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Marie-Andrée Forget"'
Autor:
Miles C. Andrews, Junna Oba, Chang-Jiun Wu, Haifeng Zhu, Tatiana Karpinets, Caitlin A. Creasy, Marie-Andrée Forget, Xiaoxing Yu, Xingzhi Song, Xizeng Mao, A. Gordon Robertson, Gabriele Romano, Peng Li, Elizabeth M. Burton, Yiling Lu, Robert Szczepaniak Sloane, Khalida M. Wani, Kunal Rai, Alexander J. Lazar, Lauren E. Haydu, Matias A. Bustos, Jianjun Shen, Yueping Chen, Margaret B. Morgan, Jennifer A. Wargo, Lawrence N. Kwong, Cara L. Haymaker, Elizabeth A. Grimm, Patrick Hwu, Dave S. B. Hoon, Jianhua Zhang, Jeffrey E. Gershenwald, Michael A. Davies, P. Andrew Futreal, Chantale Bernatchez, Scott E. Woodman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The regulation of the distinct intrinsic phenotypic states in melanoma remain poorly characterised. Here, multi-omics analysis for a panel of 68 early passage melanoma cell lines reveals that cancer cell intrinsic transcriptomic programs are associat
Externí odkaz:
https://doaj.org/article/96b59787498043a5a256fe86f8315695
Autor:
Meenu Sharma, Hiep Khong, Faisal Fa’ak, Salah-Eddine Bentebibel, Louise M. E. Janssen, Brent C. Chesson, Caitlin A. Creasy, Marie-Andrée Forget, Laura Maria S. Kahn, Barbara Pazdrak, Binisha Karki, Yared Hailemichael, Manisha Singh, Christina Vianden, Srinivas Vennam, Uddalak Bharadwaj, David J. Tweardy, Cara Haymaker, Chantale Bernatchez, Shixia Huang, Kimal Rajapakshe, Cristian Coarfa, Michael E. Hurwitz, Mario Sznol, Patrick Hwu, Ute Hoch, Murali Addepalli, Deborah H. Charych, Jonathan Zalevsky, Adi Diab, Willem W. Overwijk
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell resp
Externí odkaz:
https://doaj.org/article/ef1801862b2840b0a440db03c657db66
Autor:
Edwin R. Parra, Pamela Villalobos, Carmen Behrens, Mei Jiang, Apar Pataer, Stephen G. Swisher, William N. William, Jiexin Zhang, Jack Lee, Tina Cascone, John V. Heymach, Marie-Andrée Forget, Cara Haymaker, Chantale Bernatchez, Neda Kalhor, Annikka Weissferdt, Cesar Moran, Jianjun Zhang, Ara Vaporciyan, Don L. Gibbons, Boris Sepesi, Ignacio I. Wistuba
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background The clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor types, including lung
Externí odkaz:
https://doaj.org/article/a0fbee6e3c0d4cdda806783e081be8ef
Autor:
Edwin R. Parra, Naohiro Uraoka, Mei Jiang, Pamela Cook, Don Gibbons, Marie-Andrée Forget, Chantale Bernatchez, Cara Haymaker, Ignacio I. Wistuba, Jaime Rodriguez-Canales
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues usin
Externí odkaz:
https://doaj.org/article/48f248acce0f4bd68d965c4ec09c5ab2
Autor:
Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, Vancheswaran Gopalakrishnan, Sangeetha M. Reddy, John P. Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C. Beird, Haven R. Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D. Little, Curtis Gumbs, Rebecca L. Thornton, Courtney W. Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P. Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E. Woodman, Lynda Chin, Hussein Tawbi, Michael A. Davies, Jeffrey E. Gershenwald, Rodabe N. Amaria, Isabella C. Glitza, Adi Diab, Sapna P. Patel, Jianhua Hu, Jeffrey E. Lee, Elizabeth A. Grimm, Michael T. Tetzlaff, Alexander J. Lazar, Ignacio I. Wistuba, Karen Clise-Dwyer, Brett W. Carter, Jianhua Zhang, P. Andrew Futreal, Padmanee Sharma, James P. Allison, Zachary A. Cooper, Jennifer A. Wargo
Publikováno v:
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
Melanoma: Tumor differences within a patient may explain heterogeneous responses Patients with metastatic melanoma display molecular and immune differences across tumor sites associated with differential drug responses. A team led by Jennifer Wargo f
Externí odkaz:
https://doaj.org/article/95f4f8da81aa4220b7ea3fea4b7af4b6
Autor:
Marie-Andrée Forget, René J. Tavera, Cara Haymaker, Renjith Ramachandran, Shuti Malu, Minying Zhang, Seth Wardell, Orenthial J. Fulbright, Chistopher Leroy Toth, Audrey M. Gonzalez, Shawne T. Thorsen, Esteban Flores, Arely Wahl, Weiyi Peng, Rodabe N. Amaria, Patrick Hwu, Chantale Bernatchez
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Following the clinical success achieved with the first generation of adoptive cell therapy (ACT) utilizing in vitro expanded tumor-infiltrating lymphocytes (TILs), the second and third generations of TIL ACT are evolving toward the use of genetically
Externí odkaz:
https://doaj.org/article/32c88309dbec4abdb3ae43906c3e7255
Autor:
Yong Qin, Mariana Petaccia de Macedo, Alexandre Reuben, Marie-Andrée Forget, Cara Haymaker, Chantale Bernatchez, Christine N. Spencer, Vancheswaran Gopalakrishnan, Sujan Reddy, Zachary A. Cooper, Orenthial J. Fulbright, Renjith Ramachandran, Arely Wahl, Esteban Flores, Shawne T. Thorsen, Rene J. Tavera, Claudius Conrad, Michelle D. Williams, Michael T. Tetzlaff, Wei-Lien Wang, Dan S. Gombos, Bita Esmaeli, Rodabe N. Amaria, Patrick Hwu, Jennifer A. Wargo, Alexander J. Lazar, Sapna P. Patel
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with reputable response rates in cutaneous melanoma (CM) patients. To characterize the mechanisms responsible for resistance to immunotherapy in UM, we performed immune p
Externí odkaz:
https://doaj.org/article/bc530e9b1b874349a93364fbb2c1eec1
Autor:
Yong Qin, Suhendan Ekmekcioglu, Marie-Andrée Forget, Lorant Szekvolgyi, Patrick Hwu, Elizabeth A. Grimm, Amir A. Jazaeri, Jason Roszik
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Human papillomaviruses (HPVs) play a major role in development of cervical cancer, and HPV oncoproteins are being targeted by immunotherapies. Although these treatments show promising results in the clinic, many patients do not benefit or the durabil
Externí odkaz:
https://doaj.org/article/f62a603bd6514f74aa2aeaf08fde8126
Autor:
Marie-Andrée Forget, Yannick Huon, Alexandre Reuben, Cécile Grange, Moïshe Liberman, Jocelyne Martin, Anne-Marie Mes-Masson, Nathalie Arbour, Réjean Lapointe
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41074 (2012)
Cancer can be treated by adoptive cell transfer (ACT) of T lymphocytes. However, how to optimally raise human T cells to a differentiation state allowing the best persistence in ACT is a challenge. It is possible to differentiate mouse CD8(+) T cells
Externí odkaz:
https://doaj.org/article/4f0a88f6b9fb48bcb5e185ab606935a5
Autor:
Chantale Bernatchez, Nicholas E. Navin, Michael P. Kim, Cara L. Haymaker, Anirban Maitra, David R. Fogelman, Milind Javle, Shubham Pant, Ching-Wei D. Tzeng, Matthew H.G. Katz, Mark W. Hurd, Tapsi Kumar, Min Hu, Shanshan Bai, Alexandre Reuben, Tara G. Hughes, Emi Sei, Marie-Andrée Forget, Donastas Sakellariou-Thompson, Aislyn Schalck
Pancreatic ductal adenocarcinoma (PDAC) has few effective treatments. Immunotherapy, an attractive alternative strategy, remains challenging with the lack of knowledge on the tumor-infiltrating lymphocyte (TIL) landscape in PDAC. To generate a refere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916228e1c76e5d82a408ee224c37558e
https://doi.org/10.1158/2159-8290.c.6549748.v1
https://doi.org/10.1158/2159-8290.c.6549748.v1