Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Marie Wikström Lindholm"'
Autor:
Sophie Schöllkopf, Stefan Rathjen, Micaela Graglia, Nina Was, Eliot Morrison, Adrien Weingärtner, Lucas Bethge, Judith Hauptmann, Marie Wikström Lindholm
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102336- (2024)
Phosphorothioates (PSs) can be essential in stabilizing therapeutic oligonucleotides against enzymatic degradation. However, unless synthesis is performed with stereodefined amidites, each PS introduces a chemically undefined stereocenter, resulting
Externí odkaz:
https://doaj.org/article/34571e61594a4e63803a264e06e093a5
Autor:
David A. Rider, Mona Eisermann, Kathrin Löffler, Manuela Aleku, Daniel I. Swerdlow, Sibylle Dames, Judith Hauptmann, Eliot Morrison, Marie Wikström Lindholm, Steffen Schubert, Giles Campion
Publikováno v:
Atherosclerosis. 349:240-247
The LPA gene encodes apolipoprotein (a), a key component of Lp(a), a potent risk factor for cardiovascular disease with no specific pharmacotherapy. Here we describe the pharmacological data for SLN360, a GalNAc-conjugated siRNA targeting LPA, design
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1116-1126 (2022)
Synthetic siRNA guide strands are typically designed with perfect complementarity to the passenger strand and the target mRNA. We examined whether siRNAs with intentional guide-strand bulges are functional in vitro and in vivo. Importantly, this was
Externí odkaz:
https://doaj.org/article/4bd1ec5c027246ee891115d53da7c241
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 242-250 (2020)
N-acetyl-galactosamine (GalNAc) conjugation enhances liver specificity for therapeutic oligonucleotides. Here we report on a novel design with improved activity and stability compared with a triantennary design. We applied a versatile monovalent seri
Externí odkaz:
https://doaj.org/article/4fb6babd205d4cf1b9c0491788cb5a34