Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

Autor: Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik

Publikováno v: Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021

Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b0e637383248c3671fcfcbf8c482c6
https://doi.org/10.1016/j.ymthe.2021.08.021

Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides

Autor: Hannah Pendergraff, Christian Weile, Jonas Vikeså, Charlotte Øverup, Troels Koch, Steffen Schmidt, Marie W. Lindholm

Publikováno v: Nucleic Acid Therapeutics

Methods for the quantification of antisense oligonucleotides (AONs) provide insightful information on biodistribution and intracellular trafficking. However, the established methods have not provided information on the absolute number of molecules in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a2d17daf46c1ca82b00dd01f933def
https://pubmed.ncbi.nlm.nih.gov/31618108

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial

Autor: Eveline P, van Poelgeest, Michael R, Hodges, Matthijs, Moerland, Yann, Tessier, Arthur A, Levin, Robert, Persson, Marie W, Lindholm, Kamille, Dumong Erichsen, Henrik, Ørum, Adam F, Cohen, Jacobus, Burggraaf

Publikováno v: British journal of clinical pharmacology. 80(6)

LDL-receptor expression is inhibited by the protease proprotein convertase subtilisin/kexin type 9 (PCSK9), which is considered a pharmacological target to reduce LDL-C concentrations in hypercholesterolaemic patients. We performed a first-in-human t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99821c38ecd41b2115837fa8ebd93af8
https://pubmed.ncbi.nlm.nih.gov/26261033

Very low-density lipoprotein induces interleukin-1β expression in macrophages

Autor: M. Isabella Pörn-Ares, Maria M. Stollenwerk, Mikko P.S. Ares, Jan Nilsson, Anna Larsson, Marie W. Lindholm

Publikováno v: Biochemical and Biophysical Research Communications. 335:603-608

Elevated plasma level of very low-density lipoprotein (VLDL) is a risk factor for coronary heart disease. We investigated the effect of VLDL on expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) in human peripheral blood monocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb7a08476e0b6f983b4e47203a96d80
https://doi.org/10.1016/j.bbrc.2005.07.123

Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences

Autor: Marie W. Lindholm, Gunilla Nordin Fredrikson, Paul C. Dimayuga, Jan Nilsson, Kuang-Yuh Chyu, Ingrid Söderberg, Prediman K. Shah

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 23:879-884

Objective— LDL oxidation is believed to play an important role in the development of atherosclerosis, and oxidized LDL particles have been shown to become targets for the immune system. Immunization of animals with oxidized LDL results in reduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d61a639137cdfa51a268e0f8ff1af4
https://doi.org/10.1161/01.atv.0000067937.93716.db