Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

Autor: Nichlas Riise Jespersen, Marie Vognstoft Hjortbak, Thomas Ravn Lassen, Nicolaj Brejnholt Støttrup, Jacob Johnsen, Pernille Tilma Tonnesen, Steen Larsen, Hans-Henrik Kimose, Hans Erik Bøtker

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Abstract Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remai

Externí odkaz: https://doaj.org/article/cb3202da68854c63bc7f4b39308a071c

Influence of strain, age, origin, and anesthesia on the cardioprotective efficacy by local and remote ischemic conditioning in an ex vivo rat model

Autor: Thomas Ravn Lassen, Marie Vognstoft Hjortbak, Marie Hauerslev, Pernille Tilma Tonnesen, Steen Buus Kristiansen, Rebekka Vibjerg Jensen, Hans Erik Bøtker

Publikováno v: Physiological Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)

Abstract Background Local ischemic preconditioning (IPC) and remote ischemic conditioning (RIC) induced by brief periods of ischemia and reperfusion protect against ischemia‐reperfusion injury. Methods We studied the sensitivity to IR‐injury and

Externí odkaz: https://doaj.org/article/961e68534d674ea8a4e93dcf6c49230d

Differences in intrinsic aerobic capacity alters sensitivity to ischemia-reperfusion injury but not cardioprotective capacity by ischemic preconditioning in rats.

Autor: Marie Vognstoft Hjortbak, Thomas Skjærlund Grønnebæk, Nichlas Riise Jespersen, Thomas Ravn Lassen, Jacob Marthinsen Seefeldt, Pernille Tilma Tonnesen, Rebekka Vibjerg Jensen, Lauren Gerard Koch, Steven L Britton, Michael Pedersen, Niels Jessen, Hans Erik Bøtker

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0240866 (2020)

IntroductionAerobic capacity is a strong predictor of cardiovascular mortality. Whether aerobic capacity influences myocardial ischemia and reperfusion (IR) injury is unknown.PurposeTo investigate the impact of intrinsic differences in aerobic capaci

Externí odkaz: https://doaj.org/article/ad38a54f36c045788c8f351669ffa399

Cyclic Hypoxia Conditioning Alters the Content of Myoblast-Derived Extracellular Vesicles and Enhances Their Cell-Protective Functions

Autor: IJu Lo, Marie Vognstoft Hjortbak, Stine Duelund Kaas Christensen, Tingting Gu, Kim Ryun Drasbek, Hans Erik Bøtker, Jørgen Kjems, Ping Song, Andrea E. Tóth, Susanne T. Venø, Morten Nielsen, Yan Yan, Blagoy Blagoev, Thomas Ravn Lassen, Junyi Su

Publikováno v: Biomedicines
Volume 9
Issue 9
Yan, Y, Gu, T, Christensen, S D K, Su, J, Lassen, T R, Hjortbak, M V, Lo, IJ, Venø, S T, Tóth, A E, Song, P, Nielsen, M S, Bøtker, H E, Blagoev, B, Drasbek, K R & Kjems, J 2021, ' Cyclic Hypoxia Conditioning Alters the Content of Myoblast-Derived Extracellular Vesicles and Enhances Their Cell-Protective Functions ', Biomedicines, vol. 9, no. 9 . https://doi.org/10.3390/biomedicines9091211
Biomedicines, Vol 9, Iss 1211, p 1211 (2021)
Yan, Y, Gu, T, Christensen, S D K, Su, J, Lassen, T R, Hjortbak, M V, Lo, I, Venø, S T, Tóth, A E, Song, P, Nielsen, M S, Bøtker, H E, Blagoev, B, Drasbek, K R & Kjems, J 2021, ' Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions ', Biomedicines, vol. 9, no. 9, 1211 . https://doi.org/10.3390/biomedicines9091211

Remote ischemic conditioning (RIC) is a procedure that can attenuate ischemic-reperfusion injury by conducting brief cycles of ischemia and reperfusion in the arm or leg. Extracellular vesicles (EVs) circulating in the bloodstream can release their c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319f3302e6abb71b8c6d99b16a62641e

Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats

Autor: Nichlas Riise Jespersen, Marie Vognstoft Hjortbak, Jacob Marthinsen Seefeldt, Thomas Ravn Lassen, Hans Erik Bøtker, Pernille Tilma Tonnesen

Publikováno v: Tonnesen, P T, Hjortbak, M V, Lassen, T R, Seefeldt, J M, Bøtker, H E & Jespersen, N R 2021, ' Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats ', Molecular and Cellular Biochemistry, vol. 476, no. 7, pp. 2675-2684 . https://doi.org/10.1007/s11010-021-04108-2
Molecular and Cellular Biochemistry

Inhibition of succinate dehydrogenase (SDH) by Dimethyl Malonate (DiMal) reduces cardiac ischemia–reperfusion (IR) injury. We investigated the cardioprotective effect of DiMal in a rat model during advancing type 2 diabetes. Zucker Diabetic Fatty r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8049479a8ccb1d8f1063d986adcc8c3
https://pure.au.dk/portal/da/publications/myocardial-salvage-by-succinate-dehydrogenase-inhibition-in-ischemiareperfusion-injury-depends-on-diabetes-stage-in-rats(03c99296-a0ee-460d-b5ae-9dc7b07c2b43).html