Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Marie Verbanck"'
Autor:
Ghislain Rocheleau, Iain S. Forrest, Áine Duffy, Shantanu Bafna, Amanda Dobbyn, Marie Verbanck, Hong-Hee Won, Daniel M. Jordan, Ron Do
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
A phenome-wide genomic analysis on the UK Biobank cohort links >9,000 co-localized genes and >1,400 human phenotypes across a broad selection of human tissues, representing a useful resource for the investigation of relationships between gene express
Externí odkaz:
https://doaj.org/article/0377ede494744647a1df43baeb5b3824
Autor:
Joshua K Park, Shantanu Bafna, Iain S Forrest, Áine Duffy, Carla Marquez-Luna, Ben O Petrazzini, Ha My Vy, Daniel M Jordan, Marie Verbanck, Jagat Narula, Robert S Rosenson, Ghislain Rocheleau, Ron Do
Publikováno v:
eLife, Vol 12 (2023)
Background: Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further uncle
Externí odkaz:
https://doaj.org/article/12127af73513498d96d6ca1283315804
Autor:
Alvaro N. Barbeira, Rodrigo Bonazzola, Eric R. Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari, Boxiang Liu, Abhiram Rao, Andrew R. Hamel, Milton D. Pividori, François Aguet, GTEx GWAS Working Group, Lisa Bastarache, Daniel M. Jordan, Marie Verbanck, Ron Do, GTEx Consortium, Matthew Stephens, Kristin Ardlie, Mark McCarthy, Stephen B. Montgomery, Ayellet V. Segrè, Christopher D. Brown, Tuuli Lappalainen, Xiaoquan Wen, Hae Kyung Im
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract The resources generated by the GTEx consortium offer unprecedented opportunities to advance our understanding of the biology of human diseases. Here, we present an in-depth examination of the phenotypic consequences of transcriptome regulati
Externí odkaz:
https://doaj.org/article/84ae6dd57bee4833929e3d4586a1d87a
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide
Externí odkaz:
https://doaj.org/article/50efc84e3bc2436ea0fb4e58ee18bf2f
Autor:
Yao Hu, Mariaelisa Graff, Jeffrey Haessler, Steven Buyske, Stephanie A Bien, Ran Tao, Heather M Highland, Katherine K Nishimura, Niha Zubair, Yingchang Lu, Marie Verbanck, Austin T Hilliard, Derek Klarin, Scott M Damrauer, Yuk-Lam Ho, VA Million Veteran Program, Peter W F Wilson, Kyong-Mi Chang, Philip S Tsao, Kelly Cho, Christopher J O'Donnell, Themistocles L Assimes, Lauren E Petty, Jennifer E Below, Ozan Dikilitas, Daniel J Schaid, Matthew L Kosel, Iftikhar J Kullo, Laura J Rasmussen-Torvik, Gail P Jarvik, Qiping Feng, Wei-Qi Wei, Eric B Larson, Frank D Mentch, Berta Almoguera, Patrick M Sleiman, Laura M Raffield, Adolfo Correa, Lisa W Martin, Martha Daviglus, Tara C Matise, Jose Luis Ambite, Christopher S Carlson, Ron Do, Ruth J F Loos, Lynne R Wilkens, Loic Le Marchand, Chris Haiman, Daniel O Stram, Lucia A Hindorff, Kari E North, Charles Kooperberg, Iona Cheng, Ulrike Peters
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008684 (2020)
Lipid levels are important markers for the development of cardio-metabolic diseases. Although hundreds of associated loci have been identified through genetic association studies, the contribution of genetic factors to variation in lipids is not full
Externí odkaz:
https://doaj.org/article/ca40beb39a0e40c49b79df873ea4e1d6
Autor:
Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil, Marlène Huyvaert, Clara Salazar-Cardozo, Cécile Lecoeur, Marie Verbanck, Valérie Pawlowski, Raphaël Boutry, Emmanuelle Durand, Iandry Rabearivelo, Olivier Sand, Lorella Marselli, Julie Kerr-Conte, Vikash Chandra, Raphaël Scharfmann, Odile Poulain-Godefroy, Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel, Amélie Bonnefond
Publikováno v:
Molecular Metabolism, Vol 6, Iss 6, Pp 459-470 (2017)
Objectives: Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been di
Externí odkaz:
https://doaj.org/article/34aced17f41e4cc38485bd3672620da0
Autor:
Daniel M Jordan, Hyon K Choi, Marie Verbanck, Ruth Topless, Hong-Hee Won, Girish Nadkarni, Tony R Merriman, Ron Do
Publikováno v:
PLoS Medicine, Vol 16, Iss 1, p e1002725 (2019)
BackgroundStudies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal
Externí odkaz:
https://doaj.org/article/f26a1adbf14943d1a4346160377cd12c
Autor:
Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel, Odile Poulain-Godefroy
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179583 (2017)
Bisphenol A (BPA) exposure has been suspected to be associated with deleterious effects on health including obesity and metabolically-linked diseases. Although bisphenols F (BPF) and S (BPS) are BPA structural analogs commonly used in many marketed p
Externí odkaz:
https://doaj.org/article/ca23a9a6963542488ea477efc41ca2d7
Autor:
Marie Favennec, Benjamin Hennart, Marie Verbanck, Marie Pigeyre, Robert Caiazzo, Violeta Raverdy, Hélène Verkindt, Audrey Leloire, Gilles J Guillemin, Loïc Yengo, Delphine Allorge, Philippe Froguel, François Pattou, Odile Poulain-Godefroy
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158051 (2016)
BACKGROUND:An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue. Bariatric surgery decreases low-grade
Externí odkaz:
https://doaj.org/article/f87534658c0d4383b6f39027b39681df
Autor:
Shantanu Bafna, Joshua K Park, Iain S Forrest, Áine Duffy, Carla Marquez-Luna, Ben O Petrazzini, Ha My Vy, Daniel M Jordan, Marie Verbanck, Jagat Narula, Robert S Rosenson, Ghislain Rocheleau, Ron Do
Publikováno v:
eLife. 12
Background:Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclea