Zobrazeno 1 - 10 of 104 pro vyhledávání: '"Marie Thérèse Dimanche-Boitrel"'
1
Akademický článek
Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death
Autor: Claire Delehouzé, Arnaud Comte, Stephen Adonai Leon-Icaza, Céline Cougoule, Marcelle Hauteville, Peter Goekjian, Jeannette Chloë Bulinski, Marie-Thérèse Dimanche-Boitrel, Etienne Meunier, Morgane Rousselot, Stéphane Bach
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show her
Externí odkaz: https://doaj.org/article/bec49c3acc7b48aa983463f7fc23bb1f
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2
Akademický článek
A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline
Autor: Romain Pelletier, Thomas Gicquel, Mélanie Simoes Eugenio, Pierre-Jean Ferron, Isabelle Morel, Claire Delehouzé, Marie-Thérèse Dimanche-Boitrel, Morgane Rousselot, Brendan Le Daré
Publikováno v: Pharmaceutics, Vol 14, Iss 12, p 2665 (2022)
Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline in a cross
Externí odkaz: https://doaj.org/article/f119fe69900746b2afd976e494bdf338
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3
Akademický článek
TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex
Autor: Mélanie Simoes Eugénio, Florence Faurez, Ghania H. Kara-Ali, Mélanie Lagarrigue, Perrine Uhart, Marion C. Bonnet, Isabelle Gallais, Emmanuelle Com, Charles Pineau, Michel Samson, Jacques Le Seyec, Marie-Thérèse Dimanche-Boitrel
Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a well-known apoptosis inducer and a potential anticancer agent. When caspases and inhibitors of apoptosis proteins (IAPs) are inhibited, TRAIL induces necroptosis. Molecular mechanis
Externí odkaz: https://doaj.org/article/1a61d6407de141acae70c4271ac54ab9
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4
Akademický článek
Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor
Autor: Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach
Publikováno v: Molecules, Vol 26, Iss 15, p 4599 (2021)
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate solu
Externí odkaz: https://doaj.org/article/9295c343341346118dee5825aec12a1a
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5
Akademický článek
RIPK1 protects hepatocytes from death in Fas-induced hepatitis
Autor: Aveline Filliol, Muhammad Farooq, Claire Piquet-Pellorce, Valentine Genet, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu J. M. Bertrand, Michel Samson, Jacques Le Seyec
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Hepatocyte death is a central event during liver disease progression, in which immune cells play key roles by activating members of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), including TNFR1 (TNFRSF1A), Fas (TNFRSF6) and TRAIL-
Externí odkaz: https://doaj.org/article/5a69f5dded0846c29b4a7635d8cd5204
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