Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors.

Autor: Mathieu Coureuil, Nicolas Ugolin, Marie Tavernier, Sylvie Chevillard, Vilma Barroca, Pierre Fouchet, Isabelle Allemand

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12134 (2010)

Spermatogonia- stem cells and progenitors of adult spermatogenesis- are killed through a p53-regulated apoptotic process after gamma-irradiation but the death effectors are still poorly characterized. Our data demonstrate that both intrinsic and extr

Externí odkaz: https://doaj.org/article/56a6a1157cbd42bd8ae9ba37f0e9a5e5

Abstract 1929: Establishment, molecular and pharmacological profiling of novel prostate cancer-derived xenografts from patients with advanced, treatment-refractory, disease to identify resistance mechanisms and new therapeutic options

Autor: Olivier Deas, Ludovic Bigot, Emilie Dassé, Fabrice André, Jean Charles Soria, Benjamin Besse, Stefano Cairo, Marie Tavernier, Katell Mevel, Enora Le Ven, Luc Friboulet, Jean Gabriel Judde, Yohan Loriot

Publikováno v: Cancer Research. 79:1929-1929

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men and remains one of the leading causes of cancer death worldwide. It is a highly heterogenous and complex disease, presenting serious challenges to preclinical drug development and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc2d99557bf15f236091d2d989c0fbe5
https://doi.org/10.1158/1538-7445.am2019-1929

Abstract 2147: Development of preclinical models to accelerate the identification of next generation treatments for patients with acquired resistance to targeted therapies

Autor: Fabrice Andre, Stefano Cairo, Ludovic Bigot, Yohann Loriot, Benjamin Besse, Katell Mevel, Luc Friboulet, Jean-Gabriel Judde, Jean-Charles Soria, Guillaume Lang, Marie Tavernier, Enora Le Ven, Olivier Deas

Publikováno v: Cancer Research. 78:2147-2147

The last 20 years have witnessed the identification of an increasing number of druggable oncogenic drivers and the development and clinical use of specific inhibitors against these targets. Unfortunately, patients treated with targeted therapies cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a38858e54a4d40f29eccd99ba92b6e19
https://doi.org/10.1158/1538-7445.am2018-2147

IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema

Autor: Paméla Gasse, Julien Guillet, Bernhard Ryffel, Muazzam Jacobs, Vincent Lagente, Fernando Rodrigues Coelho, Marie Tavernier, Virginie Vasseur, Lizette Fick, Sabine Charron, Isabelle Couillin, René Moser

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 183 (12), pp.8195-202. ⟨10.4049/jimmunol.0803154⟩

Lung emphysema and fibrosis are severe complications of chronic obstructive pulmonary disease, and uncontrolled protease activation may be involved in the pathogenesis. Using experimental elastase-induced acute inflammation, we demonstrate here that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0416eb465324b55e2abd838aeaeba91
https://hal.archives-ouvertes.fr/hal-00591417