Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Marie Swahn"'
Autor:
Michael P. Recht, Malte Westerhoff, Ankur M. Doshi, Matthew Young, Dana Ostrow, Dawn-marie Swahn, Sebastian Krueger, Stefan Thesen
Publikováno v:
AJR. American journal of roentgenology. 219(3)
Autor:
Aaron M. Johnson, Dawn-Marie Swahn, Irina Oyfe, Sara Abu-Ghanem, Mari Hagiwara, David Garber, Milan R. Amin, Janine M. Rotsides, Amy Smith, Ilana Bandler
Publikováno v:
The Annals of otology, rhinology, and laryngology. 129(8)
Objectives: To evaluate volume changes within the tongue post chemoradiation therapy (CRT) Study Design: Retrospective review Setting: Academic Medical Center Subjects and Methods: Subjects included 19 patients that received CRT as the primary treatm
Autor:
Britt-Marie Swahn, Ylva Gravenfors, Gunnar Nordvall, Jenny Viklund, Fredrik Rahm, Karin Kolmodin, Mats Svensson
Publikováno v:
ACS Medicinal Chemistry Letters. 5:440-445
In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. De novo design of core fragme
Autor:
Karin Kolmodin, Juliette Janson, Britt-Marie Swahn, Stefan von Berg, Tjerk Bueters, Gvido Cebers, Ann-Cathrine Radesäter, Johanna Fälting, Fredrik Jeppsson, Susanne Gustavsson, Bart Ploeger, Sofia Karlström, Susanna Eketjäll, Lise-Lotte Olsson
Publikováno v:
Journal of Biological Chemistry. 287:41245-41257
β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and formation of amyloid β peptide (Aβ) species. Because cerebral deposition of Aβ species might
Autor:
Peter Johnström, Britt-Marie Swahn, David Pyring, Magnus Schou, Margareta Bergh, Jan A.M. Neelissen, Anders Juréus, Samuel P.S. Svensson, Johan Sandell, Fredrik Jeppsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4332-4337
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. Compounds 27, 33, and 36 displayed desirable lipophilic and pharmacokinetic properties
Autor:
Marianne Graflund, Bengt Sorbe, Margareta Lood, Karin Boman, Marie Swahn, Henric Malmström, Rene Bangshoj, György Horvath
Publikováno v:
International Journal of Gynecologic Cancer. 22:47-53
ObjectivesThe purpose of this study was to assess the response rate, toxicity, progression-free survival, and overall survival in a series of patients with advanced-stage ovarian carcinoma treated with a first-line weekly docetaxel and 3 weekly carbo
Autor:
Mark C. Wenlock, Lilian Alcaraz, Dearg S. Brown, Niklas Blomberg, Simon Guile, Paul D. Leeson, Thomas Elebring, Michael J. Waring, Britt-Marie Swahn, Kamaldeep K. Chohan, Steve Swallow, Stephen A. St-Gallay, Tim Luker, Andrew Griffin, Roger John Butlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5673-5679
A valid PLS-DA model to predict attrition in pre-clinical toxicology for basic oral candidate drugs was built. A combination of aromatic/aliphatic balance, flatness, charge distribution and size descriptors helped predict the successful progression o
Autor:
Peter Johnström, Fredrik Jeppsson, Dan Sunnemark, Johan Sandell, Jan A.M. Neelissen, Allan E. Johnson, Anders Juréus, Lars Farde, Britt-Marie Swahn, Samuel P.S. Svensson
Publikováno v:
Journal of Neurochemistry. 114:784-794
Positron emission tomography (PET) radioligands that bind selectively to β-amyloid plaques (Aβ) are promising imaging tools aimed at supporting the diagnosis of Alzheimer’s disease and the evaluati ...
Autor:
Johanna Lindquist, Britt-Marie Swahn, Jenny Viklund, Jan A.M. Neelissen, Liselotte Öhberg, Istvan Macsari, Johanna Sjödin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2009-2012
The synthesis and SAR of a new series of LXR agonist is reported. The N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide hits were found in a limited screen of the AstraZeneca compound collection. The effort to optimize these hits into LXRbeta se
Publikováno v:
Ion Channel Drug Discovery ISBN: 9781849731867
In 2011, Retigabine (Ezogabine; Valeant Pharmaceuticals/GlaxoSmithKline), an opener of KCNQ (Kv7) potassium channels, was approved for the adjunctive treatment of partial-onset seizures in adult patients. In this chapter, we review the story of retig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e52f327967ac69b6aec7d98a303a578
https://doi.org/10.1039/9781849735087-00238
https://doi.org/10.1039/9781849735087-00238