Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marie Shi"'
Autor:
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk
Externí odkaz:
https://doaj.org/article/aac87a63fb79463b9e1a637cad62d4a9
Autor:
Jennifer A. Akiyama, Stella Tran, Quan T. Pham, Anne N. Harrington, Brandon J. Mannion, John L.R. Rubenstein, Momoe Kato, Catherine S. Novak, Eman Meky, Diane E. Dickel, Evgeny Z. Kvon, Ingrid Plajzer-Frick, Janeth Godoy, Veena Afzal, Len A. Pennacchio, Valentina Snetkova, Marie Shi, Athena R. Ypsilanti, Axel Visel, Yiwen Zhu, Riana D. Hunter
Publikováno v:
Nature Genetics. 53:521-528
Ultraconserved enhancer sequences show perfect conservation between human and rodent genomes, suggesting that their functions are highly sensitive to mutation. However, current models of enhancer function do not sufficiently explain this extreme evol
Autor:
Nobuyoshi Tsuzuki, Koichiro Wasano, Naoki Oishi, Ko Hentona, Marie Shimanuki, Takanori Nishiyama, Yoshihiko Hiraga, Masafumi Ueno, Narihisa Suzuki, Seiichi Shinden, Kaoru Ogawa, Hiroyuki Ozawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Atherosclerosis is reported to be a risk factor for the severity of idiopathic sudden sensorineural hearing loss (ISSNHL). We evaluated the hypothesis that atherosclerosis affects the hearing thresholds of both the affected and healthy sides
Externí odkaz:
https://doaj.org/article/4fb946f09bc441b9a8698cd88f49b49b
Autor:
Jun Zhao, Buyan Pan, Marie Fina, Yun Huang, Marie Shimogawa, Kelvin C. Luk, Elizabeth Rhoades, E. James Petersson, Dawei W. Dong, Anna Kashina
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Background Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegeneration in mi
Externí odkaz:
https://doaj.org/article/9e937010171a42dfbd72af11315ab617
Autor:
Nobuyoshi Tsuzuki, Koichiro Wasano, Naoki Oishi, Ko Hentona, Marie Shimanuki, Takanori Nishiyama, Yoshihiko Hiraga, Seiichi Shinden, Kaoru Ogawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract The cause of idiopathic sudden sensorineural hearing loss (idiopathic SSNHL)—diagnosed after excluding other causes of hearing loss, such as SSNHL associated with vestibular schwannoma (VS)—is unknown. The presumed pathogenesis of idiopa
Externí odkaz:
https://doaj.org/article/6854b4bdf65a4e77a80ff0a52fb4088e
Autor:
Marie Shinohara, Hiroshi Arakawa, Yuuichi Oda, Nobuaki Shiraki, Shinji Sugiura, Takumi Nishiuchi, Taku Satoh, Keita Iino, Sylvia Leo, Yusuke Kato, Karin Araya, Takumi Kawanishi, Tomoki Nakatsuji, Manami Mitsuta, Kosuke Inamura, Tomomi Goto, Kenta Shinha, Wataru Nihei, Kikuo Komori, Masaki Nishikawa, Shoen Kume, Yukio Kato, Toshiyuki Kanamori, Yasuyuki Sakai, Hiroshi Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Examining intestine–liver interactions is important for achieving the desired physiological drug absorption and metabolism response in in vitro drug tests. Multi-organ microphysiological systems (MPSs) constitute promising tools for evalua
Externí odkaz:
https://doaj.org/article/f3d6e51115fc431c979b3b6a3eb9921c
Publikováno v:
Journal of Biological Engineering, Vol 14, Iss 1, Pp 1-13 (2020)
Abstract Background Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide important benefits to pharma
Externí odkaz:
https://doaj.org/article/071095592f8b4cb6bb3db93c5f0c674f
Autor:
Marie Shinohara, Hyunjin Choi, Masato Ibuki, Shigeharu G. Yabe, Hitoshi Okochi, Atsushi Miyajima, Yasuyuki Sakai
Publikováno v:
Regenerative Therapy, Vol 12, Iss , Pp 14-19 (2019)
A differentiation of human induced pluripotent stem cells (hiPSCs) into definitive endoderm linage is required for a preparation of metabolic organ derived cells. The differentiation consumed high-priced cytokines and small molecules, which have hamp
Externí odkaz:
https://doaj.org/article/35d27136ce874b4d870ceb04ee8de67e
Autor:
Marie Shigematsu-Locatelli, Takashi Kawano, Tsuyoshi Koyama, Hideki Iwata, Atsushi Nishigaki, Bun Aoyama, Hiroki Tateiwa, Noriko Kitaoka, Masataka Yokoyama
Publikováno v:
JA Clinical Reports, Vol 5, Iss 1, Pp 1-5 (2019)
Abstract Background Long-term opioid treatment for chronic non-cancer pain has become controversial, given the increasing prevalence of opioid dependence. However, there is little information on therapeutic strategies for this condition in Japanese p
Externí odkaz:
https://doaj.org/article/bb2675ef5c474b0e81ea900e582fcadd
Autor:
Bun Aoyama, Takashi Kawano, Hideki Iwata, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M. Locatelli, Masataka Yokoyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 2, Pp 77-83 (2019)
The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were
Externí odkaz:
https://doaj.org/article/b7c9e3087e38472292b1f43077bdedd5