Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marie Pronot"'
Autor:
Katherine Bonnycastle, Katharine L. Dobson, Eva-Maria Blumrich, Akshada Gajbhiye, Elizabeth C. Davenport, Marie Pronot, Moritz Steinruecke, Matthias Trost, Alfredo Gonzalez-Sulser, Michael A. Cousin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Dynamin-1 is a large GTPase with an obligatory role in synaptic vesicle endocytosis at mammalian nerve terminals. Heterozygous missense mutations in the dynamin-1 gene (DNM1) cause a novel form of epileptic encephalopathy, with pathogenic mu
Externí odkaz:
https://doaj.org/article/978480a973bf49a58749c29e55169d7b
Autor:
Eva-Maria Blumrich, Jessica C. Nicholson-Fish, Marie Pronot, Elizabeth C. Davenport, Dominic Kurian, Adam Cole, Karen J. Smillie, Michael A. Cousin
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112633- (2023)
Summary: Phosphatidylinositol 4-kinase IIα (PI4KIIα) generates essential phospholipids and is a cargo for endosomal adaptor proteins. Activity-dependent bulk endocytosis (ADBE) is the dominant synaptic vesicle endocytosis mode during high neuronal
Externí odkaz:
https://doaj.org/article/a37b7a0168bf4df7ad2163b7594eb7f3
Publikováno v:
Cells, Vol 13, Iss 5, p 420 (2024)
Neurotransmission occurs within highly specialized compartments forming the active synapse where the complex organization and dynamics of the interactions are tightly orchestrated both in time and space. Post-translational modifications (PTMs) are ce
Externí odkaz:
https://doaj.org/article/8749907bbc7f4e1897b1797e927ec4d4
Autor:
Vincent Paget-Blanc, Marlene E. Pfeffer, Marie Pronot, Paul Lapios, Maria-Florencia Angelo, Roman Walle, Fabrice P. Cordelières, Florian Levet, Stéphane Claverol, Sabrina Lacomme, Mélina Petrel, Christelle Martin, Vincent Pitard, Véronique De Smedt Peyrusse, Thomas Biederer, David Perrais, Pierre Trifilieff, Etienne Herzog
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The neurotransmitter dopamine is an important regulator of brain function. Here the authors describe “dopamine hub synapses”, where dopamine transmission may act in synergy with other neurotransmitters.
Externí odkaz:
https://doaj.org/article/d9419129d0284637921db33ea1d13266
Autor:
Félicie Kieffer, Fahd Hilal, Anne-Sophie Gay, Delphine Debayle, Marie Pronot, Gwénola Poupon, Iliona Lacagne, Barbara Bardoni, Stéphane Martin, Carole Gwizdek
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Fragile X-Syndrome (FXS) represents the most common inherited form of intellectual disability and the leading monogenic cause of Autism Spectrum Disorders. In most cases, this disease results from the absence of expression of the protein FMRP encoded
Externí odkaz:
https://doaj.org/article/41567188905949fe92005c17d4060778
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108151- (2022)
During brain development, synapses undergo structural rearrangements and functional changes mediated by many molecular processes including post-translational modifications by the Small Ubiquitin-like MOdifier (SUMO). To get an overview of the endogen
Externí odkaz:
https://doaj.org/article/a8ca8e3a2e0c4b0db8cb81d3d3d6f982
Autor:
Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula Pousinha, Norma Lattuada, Sophie Abelanet, Sara Castagnola, Magda Chafai, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, Emmanuel Deval, Maura Francolini, Barbara Bardoni, Yann Humeau, Viviana Trezza, Stéphane Martin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1 R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiatio
Externí odkaz:
https://doaj.org/article/1f547051b6104cb2ae2a8dd5047148af
Autor:
Marie Pronot, Félicie Kieffer, Anne-Sophie Gay, Delphine Debayle, Raphaël Forquet, Gwénola Poupon, Lenka Schorova, Stéphane Martin, Carole Gwizdek
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Synapses are highly specialized structures that interconnect neurons to form functional networks dedicated to neuronal communication. During brain development, synapses undergo activity-dependent rearrangements leading to both structural and function
Externí odkaz:
https://doaj.org/article/12953524713c4626b238a6cd7af1dd80
Autor:
Anouar Khayachi, Carole Gwizdek, Gwénola Poupon, Damien Alcor, Magda Chafai, Frédéric Cassé, Thomas Maurin, Marta Prieto, Alessandra Folci, Fabienne De Graeve, Sara Castagnola, Romain Gautier, Lenka Schorova, Céline Loriol, Marie Pronot, Florence Besse, Frédéric Brau, Emmanuel Deval, Barbara Bardoni, Stéphane Martin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density
Externí odkaz:
https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e739
Autor:
Marie Pronot, Gwénola Poupon, Lara Pizzamiglio, Marta Prieto, Isabel Chato-Astrain, Iliona Lacagne, Lenka Schorova, Alessandra Folci, Frédéric Brau, Stéphane Martin
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (7), pp.378. ⟨10.1007/s00018-022-04405-z⟩
Cellular and Molecular Life Sciences, 2022, 79 (7), pp.378. ⟨10.1007/s00018-022-04405-z⟩
SUMOylation is a post-translational modification essential to cell homeostasis. A tightly controlled equilibrium between SUMOylation and deSUMOylation processes is also critical to the neuronal function including neurotransmitter release and synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd2e22629f09edaa893f118925b45f4
https://www.hal.inserm.fr/inserm-03714566/file/Pronot2022_Article_BidirectionalRegulationOfSynap.pdf
https://www.hal.inserm.fr/inserm-03714566/file/Pronot2022_Article_BidirectionalRegulationOfSynap.pdf
