Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Marie Pierre Malice"'
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Akademický článek
Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies
Autor: Victor Balaguer, Muna Albayaty, Eulalia Jimenez, Ulrika Wählby-Hamrén, Carol Astbury, Beatriz Seoane, Marie-Pierre Malice, Alejhandra Lei, Ajay Aggarwal, Ioannis Psallidas
Publikováno v: Respiratory Research, Vol 21, Iss S1, Pp 1-12 (2020)
Abstract Background Navafenterol (AZD8871) is a novel, long-acting, dual-pharmacology (muscarinic receptor antagonist and β2−adrenoceptor agonist) molecule in development for chronic obstructive pulmonary disease and asthma. Methods These two phas
Externí odkaz: https://doaj.org/article/87c4d69744414d70839c9c48ca61b5f7
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2
Akademický článek
Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.
Autor: Michael K McCracken, Gregory D Gromowski, Lindsey S Garver, Brad A Goupil, Kathryne D Walker, Heather Friberg, Jeffrey R Currier, Wiriya Rutvisuttinunt, Kevin L Hinton, Rebecca C Christofferson, Christopher N Mores, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Stephen J Thomas, Richard G Jarman, David W Vaughn, J Robert Putnak, Lucile Warter
Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008191 (2020)
Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhu
Externí odkaz: https://doaj.org/article/9c74002c80054d2faa4b9ece61db7f6e
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3
Akademický článek
Detection of post-vaccination enhanced dengue virus infection in macaques: An improved model for early assessment of dengue vaccines.
Autor: Maria Beatriz Borges, Renato Sergio Marchevsky, Renata Carvalho Pereira, Ygara da Silva Mendes, Luiz Gustavo Almeida Mendes, Leonardo Diniz-Mendes, Michael A Cruz, Ouafaâ Tahmaoui, Sébastien Baudart, Marcos Freire, Akira Homma, Kirsten Schneider-Ohrum, David W Vaughn, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Elena Caride, Lucile Warter
Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007721 (2019)
The need for improved dengue vaccines remains since the only licensed vaccine, Dengvaxia, shows variable efficacy depending on the infecting dengue virus (DENV) type, and increases the risk of hospitalization for severe dengue in children not exposed
Externí odkaz: https://doaj.org/article/af0650a6ca6346af80ad1ffc080b6ec3
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4
Akademický článek
Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques.
Autor: Maria Beatriz Borges, Renato Sergio Marchevsky, Ygara S Mendes, Luiz Gustavo Mendes, Ana Claudia Duarte, Michael Cruz, Ana Maria Bispo de Filippis, Pedro Fernando C Vasconcelos, Marcos Freire, Akira Homma, Sally Mossman, Edith Lepine, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Elena Caride, Lucile Warter
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196311 (2018)
The macaque is widely accepted as a suitable model for preclinical characterization of dengue vaccine candidates. However, the only vaccine for which both preclinical and clinical efficacy results were reported so far showed efficacy levels that were
Externí odkaz: https://doaj.org/article/be4fe456209a47ed8979b30afe367e49
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8
A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease
Autor: Carol Astbury, Ajay Aggarwal, Alejhandra Lei, Dave Singh, Lali Jimenez, Victor Balaguer, Marie-Pierre Malice, Ioannis Psallidas, Alexandra Jauhiainen, Rainard Fuhr, Ulrika Wählby Hamrén
Publikováno v: Singh, D, Fuhr, R, Jimenez, L, Wählby Hamrén, U, Jauhiainen, A, Malice, M, Balaguer, V, Lei, A, Aggarwal, A, Astbury, C & Psallidas, I 2019, ' A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201812-2345LE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bbc0921c37e13f78c910d8f4fd4b67
https://pubmed.ncbi.nlm.nih.gov/30768909
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10
Pharmacodynamic and pharmacokinetic results after repeated doses of AZD8871 in COPD patients
Autor: Marie-Pierre Malice, Ajay Aggarwal, Lali Jimenez, Beatriz Seoane, Carol Astbury, Dave Singh, Victor Balaguer, Ulrika Walby Hamren, Ioannis Psallidas, Alejhandra Lei
Publikováno v: Clinical Problems.
Introduction: AZD8871 is an inhaled long-acting dual muscarinic antagonist/β2 adrenoceptor agonist (MABA) for COPD/asthma. This randomized, double-blind 3-way complete crossover trial (NCT02971293) assessed the efficacy and pharmacokinetics of AZD88
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a90464936971b6e27b631f1d885c8096
https://doi.org/10.1183/13993003.congress-2018.oa1656
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