Výsledky vyhledávání - "Marie Pierre Hellio Le Graverand"

Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014

Autor: Marie-Pierre Hellio Le Graverand, Felix Eckstein

Publikováno v: Seminars in Arthritis and Rheumatism. 45:251-256

Osteoarthritis (OA) is the most common disease of synovial joints and currently lacks treatment options that modify structural pathology. Imaging is ideally suited for directly evaluating efficacy of disease-modifying OA drugs (DMOADs) in clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed95d540d12495eec9f293f1d00bdd0f
https://doi.org/10.1016/j.semarthrit.2015.06.001

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Low-Grade Inflammation in Symptomatic Knee Osteoarthritis: Prognostic Value of Inflammatory Plasma Lipids and Peripheral Blood Leukocyte Biomarkers

Autor: Virginia B. Kraus, Steven B. Abramson, Mukundan Attur, Olga V. Friese, Jonathan Samuels, Zhiguo Li, Marie Pierre Hellio Le Graverand-Gastineau, Alexander Statnikov, Leon Rybak, Svetlana Krasnokutsky, Joanne M. Jordan, Constantin F. Aliferis

Publikováno v: Arthritis & Rheumatology. 67:2905-2915

Objective Inflammatory mediators, such as prostaglandin E2 (PGE2) and interleukin-1β (IL-1β), are produced by osteoarthritic (OA) joint tissue, where they may contribute to disease pathogenesis. We undertook the present study to examine whether inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fa13712285d8bdfdcc3d4e024a5fe1
https://doi.org/10.1002/art.39279

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Choice of knee cartilage thickness change metric for different treatment goals in efficacy studies

Autor: Felix Eckstein, Robert J. Buck, Marie-Pierre Hellio Le Graverand, Wolfgang Wirth

Publikováno v: Seminars in arthritis and rheumatism. 47(3)

Introduction In knee osteoarthritis, local increase and decrease in cartilage thickness has been observed over short time intervals. Hence, averaging cartilage change across large regions may not capture the complexity of structural alterations in di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e6741a2b55efcde4ff188db550ef44
https://pubmed.ncbi.nlm.nih.gov/28645453

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Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Medial Tibiofemoral Cartilage and Its Relationship With Meniscal Pathology: A Longitudinal Study Using 3.0T Magnetic Resonance Imaging

Autor: Michel D. Crema, Deborah Burstein, Monica D. Marra, Frank W. Roemer, Ali Guermazi, Marie-Pierre Hellio Le-Graverand, Ling Li, David J. Hunter, Nitya Krishnan

Publikováno v: Arthritis & Rheumatology. 66:1517-1524

Objective To evaluate the relationship between medial meniscal pathology and cartilage matrix status using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in medial tibiofemoral cartilage in a sample of middle-aged women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a24257028932235616d2de9d1f48219
https://doi.org/10.1002/art.38518

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Changes in MR relaxation times of the meniscus with acute loading: An in vivo pilot study in knee osteoarthritis

Autor: Richard B. Souza, Thomas M. Link, Xiaojuan Li, Sharmila Majumdar, Marie-Pierre Hellio Le Graverand-Gastineau, Karupppasamy Subburaj, Bradley T. Wyman

Publikováno v: Journal of Magnetic Resonance Imaging. 41:536-543

THE MENISCUS, A fibrocartilaginous tissue found within the knee joint, is responsible for joint congruity, shock dissipation, load transmission, lubrication, and stability of the joint (1,2). The mechanical function of the meniscus largely depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8819be23f538d9615cd1b9443e834346
https://doi.org/10.1002/jmri.24546

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Considerations when designing a disease-modifying osteoarthritis drug (DMOAD) trial using radiography

Autor: Eric Vignon, R. Clemmer, Marie-Pierre Hellio Le Graverand, Colin G. Miller, Robert Brunell, Curtis W. Hayes

Publikováno v: Seminars in Arthritis and Rheumatism. 43:1-8

Using placebo data from a recently completed disease-modifying osteoarthritis (OA) drug trial, we seek to inform study design of future radiographic studies.Eligible patients aged ≥40 years, with body mass index (BMI) 25-40kg/m(2) and symptomatic k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f1209579cae1beb88fc1a9edd48d23
https://doi.org/10.1016/j.semarthrit.2012.11.006

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Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently With Radiographic and Magnetic Resonance Imaging-Determined Knee Osteoarthritis Progression

Autor: Sheng Feng, Marie Pierre Hellio Le Graverand, H. Cecil Charles, David J. Hunter, Felix Eckstein, Scott R. White, Thomas J. Schnitzer, Nancy E Lane, Virginia B. Kraus, Alan Brett, Maureen Ainslie, Mihra S. Taljanovic, Shengchu Wang

Publikováno v: Arthritis & Rheumatism. 65:1812-1821

Objective To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. Methods Longitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ad48b4bf007e64b370e0662aa9d4b27
https://doi.org/10.1002/art.37970

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Loading of the knee during 3.0 T MRI is associated with significantly increased medial meniscus extrusion in mild and moderate osteoarthritis

Autor: Marie-Pierre Hellio Le Graverand, Thomas M. Link, Richard B. Souza, Christoph Stehling, Xiaojuan Li, Bradley T. Wyman, Sharmila Majumdar

Publikováno v: European Journal of Radiology. 81:1839-1845

Standard knee MRI is performed under unloading (ULC) conditions and not much is known about changes of the meniscus, ligaments or cartilage under loading conditions (LC). The aim is to study the influence of loading of different knee structures at 3T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8941d3fadf9736f3ac4cd364b6de9754
https://doi.org/10.1016/j.ejrad.2011.05.027

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The relationship between prevalent medial meniscal intrasubstance signal changes and incident medial meniscal tears in women over a 1-year period assessed with 3.0 T MRI

Autor: Michel D. Crema, Ling Li, Monica D. Marra, Frank W. Roemer, Ali Guermazi, Bradley T. Wyman, Marcello Henrique Nogueira-Barbosa, David J. Hunter, Marie-Pierre Hellio Le Graverand

Publikováno v: Skeletal Radiology. 40:1017-1023

Intrasubstance meniscal signal changes not reaching the articular surface on fast spin echo (FSE) sequences are considered to represent mucoid degeneration on MRI. The aim of this study was to evaluate the association of prevalent intrasubstance sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e8e488120f8f49d71a9439303f7a8
https://doi.org/10.1007/s00256-011-1097-3

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