Oxygen concentration modulates colibactin production

Autor: Nadège Bossuet, Cécile Guyonnet, Camille V Chagneau, Min Tang-Fichaux, Marie Penary, Dorian Loubet, Priscilla Branchu, Eric Oswald, Jean-Philippe Nougayrede

Publikováno v: Gut Microbes, Vol 15, Iss 1 (2023)

ABSTRACTUp to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibactin in colorectal

Externí odkaz: https://doaj.org/article/a7e887f726c34b09864f17adf07da9be

Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways.

Autor: Grégory Jubelin, Frédéric Taieb, David M Duda, Yun Hsu, Ascel Samba-Louaka, Rika Nobe, Marie Penary, Claude Watrin, Jean-Philippe Nougayrède, Brenda A Schulman, C Erec Stebbins, Eric Oswald

Publikováno v: PLoS Pathogens, Vol 6, Iss 9, p e1001128 (2010)

The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates and invertebrates, belong to a family of molecules called cyclomodulins that interfere with the eukaryotic cell cycle. Cif blocks the cell cycle at both the

Externí odkaz: https://doaj.org/article/ffc0c089152b4d21b4a09b0efdf3bbd2

A novel toxic effect of foodborne trichothecenes: The exacerbation of genotoxicity

Autor: Marion Garofalo, Delphine Payros, Marie Penary, Eric Oswald, Jean-Philippe Nougayrède, Isabelle P. Oswald

Publikováno v: Environmental Pollution
Environmental Pollution, 2023, 317, pp.120625. ⟨10.1016/j.envpol.2022.120625⟩

International audience; Trichothecenes (TCT) are very common mycotoxins. While the effects of DON, the most prevalent TCT, have been extensively studied, less is known about the effect of other trichothecenes. DON has ribotoxic, pro-inflammatory, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c60b36ca660514b6e98a4fbd371b80
https://doi.org/10.1016/j.envpol.2022.120625

HlyF Produced by Extraintestinal Pathogenic Escherichia coli Is a Virulence Factor That Regulates Outer Membrane Vesicle Biogenesis

Autor: Emmanuelle Helloin, Sébastien Houle, Tetsuya Hayashi, Marie Penary, Patricia Martin, Gaëlle Porcheron, Kazunori Murase, Charles M. Dozois, Eric Oswald, Jean-Philippe Nougayrède

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (5), pp.856-65. ⟨10.1093/infdis/jiv506 ⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (5), pp.856-65. ⟨10.1093/infdis/jiv506⟩
Journal of Infectious Diseases, 2016, 213 (5), pp.856-65. ⟨10.1093/infdis/jiv506⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (5), pp.856-865. ⟨10.1093/infdis/jiv506⟩

International audience; Escherichia coli can cause extraintestinal infections in humans and animals. The hlyF gene is epidemiologically associated with virulent strains of avian pathogenic E. coli and human neonatal meningitis-associated E. coli. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d117a02375827d34ef603ad1bbe0b7d
https://hal-riip.archives-ouvertes.fr/pasteur-01351505

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

Autor: Eric Oswald, Christian Chalut, Marie Penary, Patricia Martin, Maïwenn Olier, Jean-Philippe Nougayrède, Delphine Payros, Michèle Boury, Marc Audebert, Christophe Garcie, Ingrid Marcq, Sören Schubert, Giuseppe Magistro

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2013, 9 (7), pp.e1003437. ⟨10.1371/journal.ppat.1003437⟩
PLoS Pathogens, Vol 9, Iss 7, p e1003437 (2013)
Plos Pathogens 7 (9), . (2013)
PLoS Pathogens, 2013, 9 (7), pp.e1003437. ⟨10.1371/journal.ppat.1003437⟩

In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4′-phosphopantetheinyl transferas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba8adbff1f1ebacdb5f4e375de138cb
https://hal.archives-ouvertes.fr/hal-02391854