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pro vyhledávání: '"Marie Paine"'
Autor:
Ross Collins, Hyunah Lee, D. Heulyn Jones, Jonathan M. Elkins, Jason A. Gillespie, Carys Thomas, Alex G. Baldwin, Kimberley Jones, Loren Waters, Marie Paine, John R. Atack, Simon E. Ward, Olivera Grubisha, David W. Foley
Publikováno v:
Journal of Medicinal Chemistry. 65:13705-13713
LIM domain kinases 1 and 2 (LIMK1 and LIMK2) regulate actin dynamics and subsequently key cellular functions such as proliferation and migration. LIMK1 and LIMK2 phosphorylate and inactivate cofilin leading to increased actin polymerization. As a res