TP53 drives invasion through expression of its Δ133p53β variant

Autor: Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux

Publikováno v: eLife, Vol 5 (2016)

TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base

Externí odkaz: https://doaj.org/article/f581c63f2c83491e9dc7660202f2310e

TP53 drives invasion through expression of its Δ133p53β variant

Autor: Frances V. Fuller-Pace, Samer Abdallah, Pierre Roux, Christelle Anguille, Marie P. Khoury, Alexandra Diot, Nikola Arsic, Valerie Meuray, Colin A. Purdie, Philip R. Quinlan, Judit Remenyi, St�phanie Vinot, Marion de Toledo, S�bastien M. Joruiz, Ma�lys Cren, Gilles Gadea, Lee B. Jordan, Kenneth Fernandes, Alastair M. Thompson, Jean-Christophe Bourdon

Publikováno v: eLife
eLife, eLife Sciences Publication, 2016, 5, 〈10.7554/eLife.14734〉
eLife, Vol 5 (2016)
eLife, eLife Sciences Publication, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
eLife, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩

TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e5e3665203f26a5977193bbf1fdd8
http://hal.univ-reunion.fr/hal-01703040

p53 Isoforms: An Intracellular Microprocessor?

Autor: Marie P. Khoury, Jean-Christophe Bourdon

Publikováno v: Genes & Cancer. 2:453-465

Normal function of the p53 pathway is ubiquitously lost in cancers either through mutation or inactivating interaction with viral or cellular proteins. However, it is difficult in clinical studies to link p53 mutation status to cancer treatment and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf4b850587613c150e01278db45e956
https://doi.org/10.1177/1947601911408893

Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues

Autor: Marie P, Khoury, Virginie, Marcel, Kenneth, Fernandes, Alexandra, Diot, David P, Lane, Jean-Christophe, Bourdon

Publikováno v: Methods in molecular biology (Clifton, N.J.). 962

The TP53 gene expresses at least nine different mRNA variants (p53 isoform mRNAs), including the one encoding the canonical p53 tumor suppressor protein. We have developed scientific tools to specifically detect and quantify p53 isoform expression at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e58c682a2431536fe548f297ce9fb24b
https://pubmed.ncbi.nlm.nih.gov/23150433

Detecting p53 Isoforms at Protein Level

Autor: Alexandra Diot, David P. Lane, Marie P. Khoury, Kenneth Fernandes, Virginie Marcel, Jean-Christophe Bourdon

Publikováno v: Methods in Molecular Biology ISBN: 9781627032353

The human p53 protein isoforms are expressed in several cell lines and modulate p53 tumor suppressor -activity, mainly through modulation of gene expression (1-4). Thus, identifying the pattern of p53 isoforms expression in cell lines is a key step f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26233bd4b363379c0b3911581c33011d
https://doi.org/10.1007/978-1-62703-236-0_2