Výsledky vyhledávání - "Marie O. Y. Pang"

IgE binds asymmetrically to its B cell receptor CD23

Autor: Brian J. Sutton, Marie O. Y. Pang, James M. McDonnell, Andrew J. Beavil, Louisa K. James, Anthony H. Keeble, B. Dhaliwal, Hannah J. Gould

Publikováno v: Dhaliwal, B, Pang, M O Y, Keeble, A H, James, L K, Gould, H J, McDonnell, J M, Sutton, B J & Beavil, A J 2017, ' IgE binds asymmetrically to its B cell receptor CD23 ', Scientific Reports, vol. 7, 45533 . https://doi.org/10.1038/srep45533
Scientific Reports

The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell surface receptors FcεRI and CD23. The interaction with FcεRI is primarily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cde784dd0476995bcb522349454190

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Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

Autor: Andrew J. Beavil, Norhakim Yahya, Hannah J. Gould, Marie O. Y. Pang, James M. McDonnell, B. Dhaliwal, Brian J. Sutton, Stella M. Fabiane, Daopeng Yuan

Publikováno v: Molecular Immunology

Graphical abstract
Highlights • The IgE antibody plays a central role in allergic disease. • Binding of IgE to the B-cell receptor CD23 regulates IgE synthesis. • Seven crystal forms of the IgE-binding head domain of CD23 have been analyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c12c8308dae87abfabf12fc10c425

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Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI

Autor: B. Dhaliwal, Amanda K. F. Oxbrow, Brian J. Sutton, Daopeng Yuan, Stella M. Fabiane, James M. McDonnell, Katharine Cain, Marie O. Y. Pang, Andrew J. Beavil, Hannah J. Gould, Alistair James Henry

Publikováno v: Proceedings of the National Academy of Sciences. 109:12686-12691

The role of IgE in allergic disease mechanisms is performed principally through its interactions with two receptors, FcεRI on mast cells and basophils, and CD23 (FcεRII) on B cells. The former mediates allergic hypersensitivity, the latter regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebcd416e7d7442b445361cb34169f1f
https://doi.org/10.1073/pnas.1207278109

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A tool kit for rapid cloning and expression of recombinant antibodies

Autor: Marie O. Y. Pang, Andrew J. Beavil, Heather J. Bax, Sophia N. Karagiannis, Rebecca L. Beavil, Amy E. Gilbert, Debra H. Josephs, Panagiotis Karagiannis, Hannah J. Gould, Holly Bowen, Tihomir Dodev, Louisa K. James

Publikováno v: Scientific Reports
Dodev, T S, Karagiannis, P, Gilbert, A E, Josephs, D H, Bowen, H, James, L K, Bax, H J, Beavil, R, Pang, M O, Gould, H J, Karagiannis, S N & Beavil, A J 2014, ' A tool kit for rapid cloning and expression of recombinant antibodies ', Scientific Reports, vol. 4, 5885 . https://doi.org/10.1038/srep05885

Over the last four decades, molecular cloning has evolved tremendously. Efficient products allowing assembly of multiple DNA fragments have become available. However, cost-effective tools for engineering antibodies of different specificities, isotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40a5b76a6eaeb10710a0303cd85aaba
https://pubmed.ncbi.nlm.nih.gov/25073855

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A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23

Autor: Brian J. Sutton, Daopeng Yuan, Marie O. Y. Pang, Andrew J. Beavil, B. Dhaliwal

Publikováno v: Acta Crystallographica. Section F, Structural Biology Communications

The structure of a new crystal form of IgE-Fc in complex with its B-cell receptor CD23 has been determined. The structure reveals that there is conformational variability at the interface in both IgE-Fc and CD23.
The antibody IgE plays a central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5359724ae370332a637cfa67ccddaf
https://pubmed.ncbi.nlm.nih.gov/24598915

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Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction

Autor: Richard G. Hibbert, Hannah J. Gould, James M. McDonnell, Alison M. Cooper, Brian J. Sutton, Michael W. Kao, Norhakim Yahya, Andrew J. Beavil, Heather J. Bax, Susmita Borthakur, Marie O. Y. Pang

Publikováno v: The Journal of Biological Chemistry

Background: Immunoglobulin E (IgE) has two cellular receptors, FcϵRI and CD23, that mediate distinct functional effects. Results: We have identified the CD23 binding site on IgE and show that FcϵRI and CD23 allosterically compete for binding. Concl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e351006f6902ef35981574c6087b63e
https://pubmed.ncbi.nlm.nih.gov/22815482

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