Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms.

Autor: Marie Mi Bonde, Jonas Tind Hansen, Samra Joke Sanni, Stig Haunsø, Steen Gammeltoft, Christina Lyngsø, Jakob Lerche Hansen

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14135 (2010)

Seven transmembrane receptors (7TMRs) can adopt different active conformations facilitating a selective activation of either G protein or β-arrestin-dependent signaling pathways. This represents an opportunity for development of novel therapeutics t

Externí odkaz: https://doaj.org/article/86819fd62a8e44de89068ff9032481c4

The valuable insights of patients: Two case studies

Autor: Marie Mi Bonde Hansen

Publikováno v: Regulatory Affairs Watch. 3:33-35

Because of their lived experience, patients provide unique insights and perspectives on clinical research studies. This article presents two case studies from the University Hospital Basel that illustrate how researchers and patients can collaborate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0858fc981a15dbca6f1e9409b610fa8a
https://doi.org/10.54920/scto.2021.rawatch.6.33

Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality

Autor: Gordon H. Guyatt, Belinda von Niederhäusern, Matthias Briel, Marie Mi Bonde, Stefan Schandelmaier, Lars G. Hemkens, Nicole Brunner, Marielle Rutquist, Christiane Pauli-Magnus, Neera Bhatnagar

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180635 (2017)
PLoS ONE

Objective To systematically survey existing definitions, concepts, and criteria of clinical research quality, both developed by stakeholder groups as well as in the medical literature. This study serves as a first step in the development of a compreh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c17fc84a567bc236e397082dbb9f53
http://europepmc.org/articles/PMC5513422?pdf=render

An Angiotensin II type 1 receptor activation switch patch revealed through Evolutionary Trace analysis

Autor: Jennifer L. Whistler, Srinivasan Madabushi, Marie Mi Bonde, Jakob Lerche Hansen, Jian-Nong Ma, Rong Yao, Søren P. Sheikh, Ethan S. Burstein, Stig Haunsø, Olivier Lichtarge

Publikováno v: Bonde, M M, Yao, R, Ma, J-N, Madabushi, S, Haunsø, S, Burstein, E S, Whistler, J L, Sheikh, S P, Lichtarge, O & Hansen, J L 2010, ' An Angiotensin II type 1 receptor activation switch patch revealed through Evolutionary Trace analysis ', Biochemical Pharmacology, vol. 80, no. 1, pp. 86-94 . https://doi.org/10.1016/j.bcp.2010.03.006

Udgivelsesdato: 2010-Mar-21 Seven transmembrane (7TM) or G protein-coupled receptors constitute a large superfamily of cell surface receptors sharing a structural motif of seven transmembrane spanning alpha helices. Their activation mechanism most li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0351c28ca5fa26e63a7fec00b0a22e
https://doi.org/10.1016/j.bcp.2010.03.006

Quantification of pre-mRNA escape rate and synergy in splicing

Autor: Bertrand Séraphin, Attila Becskei, Marie Mi Bonde, Sylvia Voegeli, Antoine Baudrimont

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (20), pp.12847-12860. ⟨10.1093/nar/gku1014⟩

Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity. We calculated the escape rate for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c523772f62eb0272f4070a0f10cad8
https://hal.archives-ouvertes.fr/hal-02179569/file/islandora_55186.pdf