Exploring the in vitro stability of insulin degrading enzyme as a potential biomarker for neurocognitive disorders and Alzheimer's disease risk

Autor: Helena Kullenberg, Marie M. Svedberg

Publikováno v: Practical Laboratory Medicine, Vol 40, Iss , Pp e00400- (2024)

Insulin degrading enzyme (IDE) plays a critical role in degrading insulin and beta-forming proteins, implicating its significance as a biomarker in metabolic dysfunction and neurocognitive disorders, including Alzheimer's disease (AD). Understanding

Externí odkaz: https://doaj.org/article/e83e2d5ef8cb4d7e98885aad66d255c0

Associations Between the Use of Metformin and Behavioral and Psychological Symptoms in Patients with Alzheimer´s Disease, and Type 2 Diabetes Mellitus – a Register-Based Study

Autor: Helena Kullenberg, Moa Wibom, Maria Kumlin, Thomas Nyström, Marie M. Svedberg

Publikováno v: Current Alzheimer Research. 20

Background: Metformin, the first-line anti-diabetic drug treatment in patients with type 2 diabetes mellitus (T2DM), is suggested to be anti-inflammatory, antioxidative, and improve cognitive function, making it a promising contribution to treating A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5b37455af38d8bad78a06c2a3043dc
https://doi.org/10.2174/1567205020666230522102641

Synthesis and labeling of a piperazine-based library of11C-labeled ligands for imaging of the vesicular acetylcholine transporter

Autor: Sara Bergman, Alf Thibblin, Mats Larhed, Håkan Hall, Rashidur Rahman, Andreas Blomgren, Fredrik Wångsell, Gunnar Antoni, Sergio Estrada, Marie M. Svedberg

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 57:525-532

The cholinergic system is involved in neurodegenerative diseases, and visualization of cholinergic innervations with positron emission tomography (PET) would be a useful tool in understanding these ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22481e65d56e079a95e6bf2c79ba1110
https://doi.org/10.1002/jlcr.3208

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain

Autor: Marie M. Svedberg, Dag Sehlin, Gunnar Antoni, Vladimir Tolmachev, Mats Holmquist, Håkan Hall, Karin Tegerstedt, Kristina Magnusson, Lars N.G. Nilsson, Lars Lannfelt, Ola Philipson, Linda Söderberg, Pär Gellerfors, Stina Syvänen

Publikováno v: Journal of Alzheimer's disease : JAD. 37(1)

Evidence suggests that amyloid-β (Aβ) protofibrils/oligomers are pathogenic agents in Alzheimer's disease (AD). Unfortunately, techniques enabling quantitative estimates of these species in patients or patient samples are still rather limited. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949f505a92328fc2abba7ee32286a541
https://pubmed.ncbi.nlm.nih.gov/23780660

Mucosal LTE 4 , PGD 2 and 15(S)-HETE as potential prognostic markers for polyp recurrence in chronic rhinosinusitis.

Autor: Nordström A; Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden., Jangard M; Department of Otorhinolaryngology, Sophiahemmet Hospital, Stockholm, Sweden., Ryott M; Department of Otorhinolaryngology, Sophiahemmet Hospital, Stockholm, Sweden., Tang X; Division of Physiological Chemistry II, Biomedicum 9A, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Svedberg M; Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden., Kumlin M; Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden; Division of Physiological Chemistry II, Biomedicum 9A, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Electronic address: maria.kumlin@shh.se.

Publikováno v: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Oct; Vol. 174, pp. 106886. Date of Electronic Publication: 2024 Aug 22.