Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Marie Lise Maddelein"'
Autor:
Xing Wang, Chen Zhang, Ryma Madji, Camille Voros, Serge Mazères, Christian Bijani, Céline Deraeve, Olivier Cuvillier, Heinz Gornitzka, Marie-Lise Maddelein, Catherine Hemmert
Publikováno v:
Molecules, Vol 28, Iss 2, p 691 (2023)
A series of seven novel iridium complexes were synthetized and characterized as potential photosensitizers for photodynamic therapy (PDT) applications. Among them, four complexes were evaluated in vitro for their anti-proliferative activity with and
Externí odkaz:
https://doaj.org/article/a8383a8838dc4a4aa0e310a18f8a6089
Autor:
Gaëlle Dominguez, Marie-Lise Maddelein, Mélanie Pucelle, Yvan Nicaise, Claude-Alain Maurage, Charles Duyckaerts, Olivier Cuvillier, Marie-Bernadette Delisle
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid (Aβ) peptides and hyperphosphorylated tau protein accompanied by neuronal loss. Aβ accumulation has been associated with an impaired sphingosine 1-pho
Externí odkaz:
https://doaj.org/article/ce69ced8f33d4e9588c9c53a99773bdc
Autor:
Anne Gomez-Brouchet, Claire Illac, Adeline Ledoux, Pierre-Yves Fortin, Sandra de Barros, Clémentine Vabre, Fabien Despas, Sophie Peries, Christelle Casaroli, Corinne Bouvier, Sébastien Aubert, Gonzague de Pinieux, Frédérique Larousserie, Louise Galmiche, Franck Talmont, Stuart Pitson, Marie-Lise Maddelein, Olivier Cuvillier
Publikováno v:
Cancers; Volume 14; Issue 3; Pages: 499
Cancers, Vol 14, Iss 499, p 499 (2022)
Cancers, Vol 14, Iss 499, p 499 (2022)
The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b399a9bb5bdb0c14a183fc846a780c
https://hdl.handle.net/11541.2/27082
https://hdl.handle.net/11541.2/27082
Autor:
Marie-Lise Maddelein, Olivier Cuvillier, Christian Bijani, Xing Wang, Catherine Hemmert, Xue Qin, Pierre-Yves Fortin, Heinz Gornitzka, Chen Zhang, Álvaro Fernández Álvarez, Guillaume Barnoin
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
A family of original bis(artemisinin-NHC)gold(I) complexes have been synthesized. These hybrid molecules combine two biological active motifs, an artemisinin derivative (DHA) and a cationic bis(NHC)gold(I) unit. One of these complexes, complex 2a, ha
Autor:
Olivier Cuvillier, Catherine Hemmert, Xing Wang, Chen Zhang, Álvaro Fernández Álvarez, Pierre-Yves Fortin, Christian Bijani, Xue Qin, Guillaume Barnoin, Marie-Lise Maddelein, Heinz Gornitzka
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
Angewandte Chemie International Edition, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
Angewandte Chemie International Edition, 2020, 59 (29), pp.12062-12068. ⟨10.1002/anie.202002992⟩
A family of original bis(artemisinin-NHC)gold(I) complexes have been synthesized. These hybrid molecules combine two biological active motifs, an artemisinin derivative (DHA) and a cationic bis(NHC)gold(I) unit. One of these complexes, complex 2a, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6514059b1678f18e5803ee064be1d16f
https://doi.org/10.26434/chemrxiv.11629113.v1
https://doi.org/10.26434/chemrxiv.11629113.v1
Autor:
Petra Smickova, Vítězslav Kolek, Olivier Cuvillier, Jozef Skarda, Ivona Grygárková, Jiří Klein, Mariam Gachechiladze, Lucia Cierna, Giorgi Mgebrishvili, Stuart M. Pitson, Maria Janikova, Marie Lise Maddelein, Tomáš Tichý, Gvantsa Kharaishvili
Publikováno v:
Oncology Letters
Oncology Letters, Spandidos Publications, 2019, ⟨10.3892/ol.2019.10447⟩
Oncology Letters, Spandidos Publications, 2019, ⟨10.3892/ol.2019.10447⟩
Sphingosine 1-phosphate (S1P) is a bioactive lipid metabolite associated with cancer cell proliferation, survival, migration and regulation of tumor angiogenesis in various cellular and animal models. Sphingosine kinase-1 (SphK1) and S1P lyase are th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42585fcb05a6b5cff06c75decf25e0ce
https://hal.archives-ouvertes.fr/hal-02407039
https://hal.archives-ouvertes.fr/hal-02407039
Autor:
Olivier Cuvillier, Raymond Wai-Yin Sun, Marie-Lise Maddelein, Catherine Hemmert, Chen Zhang, Heinz Gornitzka
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 157, pp.320-332. ⟨10.1016/j.ejmech.2018.07.070⟩
European Journal of Medicinal Chemistry, Elsevier, 2018, 157, pp.320-332. ⟨10.1016/j.ejmech.2018.07.070⟩
International audience; A series of four new mononuclear cationic gold(I) complexes containing nitrogen functionalized N-heterocyclic carbenes (NHCs) was synthesized and fully characterized by spectroscopic methods. The X-ray structures of three comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf028b4e72ef787206f3924c1130223b
https://hal.archives-ouvertes.fr/hal-01963519
https://hal.archives-ouvertes.fr/hal-01963519
Autor:
Salvador Ventura, Alba Espargaró, Javier Sancho, José Alberto Carrodeguas, L. López, Marie-Lise Maddelein, Suzana Dos-Reis
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9521-9530. ⟨10.1021/jm301186p⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9521-9530. ⟨10.1021/jm301186p⟩
Alzheimer's disease, characterized by deposits of amyloid β-peptide (Aβ), is the most common neurodegenerative disease, but it still lacks a specific treatment. We have discovered five chemically unrelated inhibitors of the in vitro aggregation of
Autor:
Emmanuelle Mothes, Cindy Figueroa, Anaïs Mockel, Maéva Vignes, Marie-Christine Miquel, Marie Lise Maddelein, Lorena Perrone, Peter Faller
Publikováno v:
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2010, 11 (1), pp.110-118. ⟨10.1002/cbic.200900474⟩
ChemBioChem, Wiley-VCH Verlag, 2010, 11 (1), pp.110-118. ⟨10.1002/cbic.200900474⟩
Amyloid-beta peptides (Abeta) and the protein human serum albumin (HSA) interact in vivo. They are both localised in the blood plasma and in the cerebrospinal fluid. Among other functions, HSA is involved in the transport of the essential metal coppe
Autor:
Marie-Lise Maddelein, Virginie Garcia, Dimitri Pchejetski, Leyre Brizuela, Marie-Bernadette Delisle, Marie-Françoise Altié, A. Gomez-Brouchet, Olivier Cuvillier
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 72 (2), pp.341-349. ⟨10.1124/mol.106.033738⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 72 (2), pp.341-349. ⟨10.1124/mol.106.033738⟩
International audience; We examined the role of sphingosine kinase-1 (SphK1), a critical regulator of the ceramide/sphingosine 1-phosphate (S1P) biostat, in the regulation of death and survival of SH-SY5Y neuroblastoma cells in response to amyloid be