The properties of hot household hygroscopic materials and their potential use for non-medical facemask decontamination.

Autor: Marie-Line Andreola, Fréderic Becquart, Wahbi Jomaa, Paul O Verhoeven, Gérard Baldacchino, Simon Hemour, D-Mask consortium

Publikováno v: PLoS ONE, Vol 16, Iss 9, p e0255148 (2021)

The widespread use of facemasks throughout the population is recommended by the WHO to reduce transmission of the SARS-CoV-2 virus. As some regions of the world are facing mask shortages, reuse may be necessary. However, used masks are considered as

Externí odkaz: https://doaj.org/article/f69068942fe9420486d357372efa2899

Absence of Resistance Mutations in the Integrase Coding Region among ART-Experienced Patients in the Republic of the Congo

Autor: Ferdinand Emaniel Brel Got, Patricia Recordon-Pinson, Ghislain Loubano-Voumbi, Dagene Ebourombi, Marie-Lise Blondot, Mathieu Metifiot, Gontran Ondzotto, Marie-Line Andreola

Publikováno v: Microorganisms, Vol 9, Iss 11, p 2355 (2021)

Background: HIV infects around one hundred thousand patients in the Republic of the Congo. Approximately 25% of them receive an antiretroviral treatment; current first-line regimens include two NRTIs and one NNRTI, reverse transcriptase inhibitors. R

Externí odkaz: https://doaj.org/article/d182430eeec342d79337e611664cf62a

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails

Autor: Mohamed S. Benleulmi, Julien Matysiak, Xavier Robert, Csaba Miskey, Eric Mauro, Delphine Lapaillerie, Paul Lesbats, Stéphane Chaignepain, Daniel R. Henriquez, Christina Calmels, Oyindamola Oladosu, Eloïse Thierry, Oscar Leon, Marc Lavigne, Marie-Line Andreola, Olivier Delelis, Zoltán Ivics, Marc Ruff, Patrice Gouet, Vincent Parissi

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-16 (2017)

Abstract Background Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein

Externí odkaz: https://doaj.org/article/62671881f03f4030ac954009c672ddde

De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain

Autor: Christina Calmels, Michel Ventura, Cindy Aknin, Mathieu Métifiot, Marie-Line Andreola

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapie

Externí odkaz: https://doaj.org/article/5d7e140debe44068a932d7d7642b5a5f

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Autor: Nicole Grandi, Enzo Tramontano, Francesca Esposito, Davide Ialongo, Alessandro De Leo, Giorgio Amendola, Daniela De Vita, Antonella Messore, Valentina Noemi Madia, Marie-Line Andreola, Ettore Novellino, Mathieu Métifiot, Sandro Cosconati, Roberta Costi, Angela Corona, Roberto Di Santo, Valeria Tudino, Francesco Saccoliti, Luigi Scipione

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (12), pp.8579-8598. ⟨10.1021/acs.jmedchem.1c00535⟩

Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents a validated and promising target, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7119c7f6ddd81a9fee5dea8606a4e7
https://doi.org/10.1021/acs.jmedchem.1c00535