PlzR regulates type IV pili assembly in Pseudomonas aeruginosa via PilZ binding

Autor: Hanne Hendrix, Annabel Itterbeek, Hannelore Longin, Lize Delanghe, Eveline Vriens, Marta Vallino, Eveline-Marie Lammens, Farhana Haque, Ahmed Yusuf, Jean-Paul Noben, Maarten Boon, Matthias D. Koch, Vera van Noort, Rob Lavigne

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Type IV pili (T4P) are thin, flexible filaments exposed on the cell surface of gram-negative bacteria and are involved in pathogenesis-related processes, including cell adsorption, biofilm formation, and twitching motility. Bacteriophages of

Externí odkaz: https://doaj.org/article/71ed362eb03f4fa1880aa96c61c04493

Development of ONT-cappable-seq to unravel the transcriptional landscape of Pseudomonas phages

Autor: Leena Putzeys, Maarten Boon, Eveline-Marie Lammens, Konstantin Kuznedelov, Konstantin Severinov, Rob Lavigne

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2624-2638 (2022)

RNA sequencing has become the method of choice to study the transcriptional landscape of phage-infected bacteria. However, short-read RNA sequencing approaches generally fail to capture the primary 5′ and 3′ boundaries of transcripts, confounding

Externí odkaz: https://doaj.org/article/a67edec9467e43d1a50baf29da314c32

Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria

Autor: Eveline-Marie Lammens, Pablo Ivan Nikel, Rob Lavigne

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Non-model bacteria offer unique and versatile metabolisms for synthetic biology. In this Perspective, the authors explore the limited availability of well-characterised biological parts in these species and argue that bacteriophages represent a diver

Externí odkaz: https://doaj.org/article/307774c564214366a295c71f6a68f927

Neural network algorithm for detection of erosions and ankylosis on CT of the sacroiliac joints: multicentre development and validation of diagnostic accuracy

Autor: Thomas Van Den Berghe, Danilo Babin, Min Chen, Martijn Callens, Denim Brack, Helena Maes, Jan Lievens, Marie Lammens, Maxime Van Sumere, Lieve Morbée, Simon Hautekeete, Stijn Schatteman, Tom Jacobs, Willem-Jan Thooft, Nele Herregods, Wouter Huysse, Jacob L. Jaremko, Robert Lambert, Walter Maksymowych, Frederiek Laloo, Xenofon Baraliakos, Ann-Sophie De Craemer, Philippe Carron, Filip Van den Bosch, Dirk Elewaut, Lennart Jans

Publikováno v: European Radiology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::871d17fdc7cdb0a71a8ab74d38dc6b45
https://doi.org/10.1007/s00330-023-09704-y

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Autor: Jozef Anné, Eveline-Marie Lammens, Piet Herdewijn, Thomas Lathouwers, Matthew P. Crump, Michiel Vanmeert, Harry Cuppens, Joleen Masschelein, Ruben Degroote, Eveline Lescrinier, Ling-Jie Gao, Rob Lavigne, Angus N M Weir, Simone Kosol, Thomas J. Simpson, Kristof Vrancken, Christine L. Willis, Christopher D. Fage

Publikováno v: Fage, C D, Lathouwers, T, Vanmeert, M, Gao, L-J, Vrancken, K, Lammens, E-M, Weir, A N M, Degroote, R, Cuppens, H, Kosol, S, Simpson, T J, Crump, M P, Willis, C L, Herdewijn, P, Lescrinier, E, Lavigne, R, Anné, J & Masschelein, J 2020, ' The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI ', Angewandte Chemie-International Edition, vol. 59, no. 26, pp. 10549-10556 . https://doi.org/10.1002/anie.201915407

The enoyl-acyl carrier protein reductase enzyme FabI is essential for fatty acid biosynthesis in Staphylococcus aureus and represents a promising target for the development of novel, urgently needed anti-staphylococcal agents. Here, we elucidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c3714deeb6f24a44b0d654bb7f33bb
https://doi.org/10.1002/anie.201915407