Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marie Lagouge"'
Autor:
Marie Lagouge, Arnaud Mourier, Hyun Ju Lee, Henrik Spåhr, Timothy Wai, Christian Kukat, Eduardo Silva Ramos, Elisa Motori, Jakob D Busch, Stefan Siira, German Mouse Clinic Consortium, Elisabeth Kremmer, Aleksandra Filipovska, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005423 (2015)
We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on
Externí odkaz:
https://doaj.org/article/e1bf9ab72edd4e89b4da90f991133906
Autor:
Anna Wredenberg, Marie Lagouge, Ana Bratic, Metodi D Metodiev, Henrik Spåhr, Arnaud Mourier, Christoph Freyer, Benedetta Ruzzenente, Luke Tain, Sebastian Grönke, Francesca Baggio, Christian Kukat, Elisabeth Kremmer, Rolf Wibom, Paola Loguercio Polosa, Bianca Habermann, Linda Partridge, Chan Bae Park, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003178 (2013)
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial t
Externí odkaz:
https://doaj.org/article/552ff24687c845449ceccce47f040473
Publikováno v:
Nature Reviews Endocrinology. 12:710-722
Hepatic steatosis, the first step in the progression of nonalcoholic fatty liver disease, is characterized by triglyceride accumulation in hepatocytes and is highly prevalent in people with obesity. Although initially asymptomatic, hepatic steatosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6ef34e7bd0fbf8742d054b5b4e8adb
https://doi.org/10.1038/nrendo.2016.124
https://doi.org/10.1038/nrendo.2016.124
Autor:
Tobias Brandt, Anne Galinier, Marie Lagouge, Elisa Motori, Susanne Brodesser, Christoph Dieterich, Kjell Hultenby, Gunter Rappl, Ilian Atanassov, Nils-Göran Larsson, Arnaud Mourier
Publikováno v:
The Journal of Cell Biology
J Cell Biol
J Cell Biol
Mitofusin 2 plays an unexpected role in maintaining the terpenoid biosynthesis pathway and is necessary for mitochondrial coenzyme Q biosynthesis.
Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. De
Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8bf846891ae6736bf2b5f61f404023
https://doi.org/10.1083/jcb.201411100
https://doi.org/10.1083/jcb.201411100
Autor:
Carles Cantó, Sander M. Houten, Jill C. Milne, Johan Auwerx, Marie Lagouge, Axelle Strehle, Philip D. Lambert, Jerome N. Feige, Chikage Mataki, Peter J. Elliott
Publikováno v:
Cell Metab
Cell Metab, 2008, 8 (5), pp.347-58. ⟨10.1016/j.cmet.2008.08.017⟩
Cell metabolism, 8(5), 347-358. Cell Press
Cell Metab, 2008, 8 (5), pp.347-58. ⟨10.1016/j.cmet.2008.08.017⟩
Cell metabolism, 8(5), 347-358. Cell Press
International audience; The NAD(+)-dependent deacetylase SIRT1 controls metabolic processes in response to low nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a290e3efe323a8fb0a3889a6247f60e
Publikováno v:
médecine/sciences. 23:840-844
Neurodegenerative diseases are more and more prevalent in our aging societies. A rapid overview of the etiology of many neurodegenerative diseases like Alzheimer, Parkinson, Huntington disease and amyotrophic lateral sclerosis suggests a tight link w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d634d58640c49ef2b7f1dd2e6d17f1ed
https://doi.org/10.1051/medsci/20072310840
https://doi.org/10.1051/medsci/20072310840
Autor:
Marie Lagouge, Gabriele Schneider, Joanna Adamczak, Markus Aswendt, Peter Kloppenburg, Dirk Wiedermann, Marion Selt, Cordula Schaefer, Nadine Henn, Ursel Collienne, Mathias Hoehn, Annette Tennstaedt
Publikováno v:
Biomaterials, 44, 143-154
Human neural stem cells (hNSCs) hold great promise for the treatment of neurological diseases. Considerable progress has been made to induce neural differentiation in the cell culture in vitro and upon transplantation in vivo [2] in order to explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b786eb118c13cb593d75575713ded2
https://pubmed.ncbi.nlm.nih.gov/25617134
https://pubmed.ncbi.nlm.nih.gov/25617134
Autor:
Christoph Freyer, James B. Stewart, Nils-Göran Larsson, Arnaud Mourier, Lars Olson, Marie Lagouge, Jaime M. Ross, Giuseppe Coppotelli, Barry J. Hoffer, Erik Hagström, Stefan Brené
Publikováno v:
Nature
Ageing is due to an accumulation of various types of damage, and mitochondrial dysfunction has long been considered to be important in this process. There is substantial sequence variation in mammalian mitochondrial DNA (mtDNA), and the high mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239be6a7c0383c7696c2f69acb7779ef
https://hdl.handle.net/21.11116/0000-000B-7297-A
https://hdl.handle.net/21.11116/0000-000B-7297-A
Autor:
Marie Lagouge, Nils-Göran Larsson
Publikováno v:
Journal of Internal Medicine
J Intern Med
J Intern Med
Considerable efforts have been made to understand the role of oxidative stress in age-related diseases and ageing. The mitochondrial free radical theory of ageing, which proposes that damage to mitochondrial DNA (mtDNA) and other macromolecules cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a582a9197210b27e764cc274e34549
https://pubmed.ncbi.nlm.nih.gov/23432181
https://pubmed.ncbi.nlm.nih.gov/23432181
Autor:
Ilian Atanassov, Eduardo Silva Ramos, Marie Lagouge, Elisa Motori, Gunter Rappl, Nils-Göran Larsson, Arnaud Mourier, Christoph Dieterich, Tobias Brandt, Susanne Brodesser, Kjell Hultenby, Anne Galinier
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857:e15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c7ad8e3a8928ac9afad8c4ee1fb0ce
https://doi.org/10.1016/j.bbabio.2016.04.386
https://doi.org/10.1016/j.bbabio.2016.04.386