Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marie L. Woolley"'
Autor:
Marie L. Woolley, Lee A. Dawson, Elisa Ballini, Kerry A. Waters, Mark H Harries, Laura Aldegheri, Simon E. Ward, Joanne Pardoe, Laurent Lacroix, John R. Atack, Kathryn R. Starr, Annette Weil, Andrea M. Bradford
Publikováno v:
J Psychopharmacol
Purpose: There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disor
Autor:
Novella Calcinaghi, Declan N.C. Jones, Laurent Lacroix, Lee A. Dawson, M. H. Selina Mok, Kathryn R. Starr, Jane Gartlon, Joanne Pardoe, Francesca Graziani, Mark H Harries, Simon E. Ward, Marie L. Woolley, Paul John Beswick, Beatrice Oliosi
Publikováno v:
British Journal of Pharmacology. 174:370-385
Background and Purpose AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with schizophrenia. These studies collectively constitute the preclinical pharmacology data package used to
Autor:
Simon E, Ward, Paul, Beswick, Novella, Calcinaghi, Lee A, Dawson, Jane, Gartlon, Francesca, Graziani, Declan N C, Jones, Laurent, Lacroix, M H, Selina Mok, Beatrice, Oliosi, Joanne, Pardoe, Kathryn, Starr, Marie L, Woolley, Mark H, Harries
Publikováno v:
British journal of pharmacology. 174(5)
AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with schizophrenia. These studies collectively constitute the preclinical pharmacology data package used to build confidence in the
Publikováno v:
Psychopharmacology. 206:403-414
5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. The aim of this study was to investigate the involvement of 5-HT receptor mechanisms in sub-chronic phencyclidine (PCP)-induced reversal learning defi
Publikováno v:
Journal of Psychopharmacology. 24:787-790
Female hooded-Lister rats received either subchronic phencyclidine (PCP) (2 mg/kg, n = 20) or vehicle (1 ml/kg, n = 20) intraperitoneally twice daily for 7 days, followed by a 7-day washout period. Rats were challenged with acute PCP or vehicle and t
Publikováno v:
Journal of Psychopharmacology. 24:57-63
It has been suggested that the isolation rearing paradigm models certain aspects of schizophrenia symptomatology. This study aimed to investigate whether isolation rearing impairs rats’ performance in two models of cognition: the novel object recog
Publikováno v:
Behavioural Brain Research. 189:152-158
RATIONALE: The NMDA receptor antagonist, phencyclidine (PCP), has been shown to induce symptoms characteristic of schizophrenia. A loss in executive function and the ability to shift attention between stimulus dimensions is impaired in schizophrenia;
Autor:
Marie L. Woolley, Jörg Huwyler, Theresa M. Ballard, Eric Prinssen, Will Spooren, Porter Richard Hugh Phillip
Publikováno v:
Psychopharmacology. 179:218-229
Antagonists at the metabotropic glutamate 5 (mGlu5) receptor produce robust anxiolytic effects in a number of rat tests. However, there is evidence that mGlu5 receptor antagonists may also impair working memory and spatial learning following intracer
Autor:
David Bleakman, Erica F. Sharpe, Catherine P. Bath, Hywel R Bufton, Marie L. Woolley, Darryle D. Schoepp, Barbara A Ballyk, István Tarnawa, Andrew J Palmer, David Lodge, Rajender Kamboj
Publikováno v:
Neuropharmacology. 35:1689-1702
The activity and selectivity of the glutamate receptor antagonists belonging to the 2,3-benzodiazepine class of compounds have been examined at recombinant human non-NMDA glutamate receptors expressed in HEK293 cells and on native rat NMDA and non-NM
Autor:
Ajit J. Shah, Anne-Cécile Fricker, Raul de la Flor, Marie L. Woolley, Lee A. Dawson, M. H. Selina Mok, James N.C. Kew
Publikováno v:
Neuropharmacology. 56(6-7)
A group II metabotropic glutamate receptor (mGluR) agonist was recently reported to be clinically efficacious against symptoms of schizophrenia [Patil, S.T., Zhang, L., Martenyi, F., Lowe, S.L., Jackson, K.A., Andreev, B.V., Avedisova, A.S., Bardenst