Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marie Klinge Brimnes"'
Autor:
Marie Klinge Brimnes, Bjarke Endel Hansen, Leif Kofoed Nielsen, Morten Hanefeld Dziegiel, Claus Henrik Nielsen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113388 (2014)
B cells may play both pathogenic and protective roles in T-cell mediated autoimmune diseases such as multiple sclerosis (MS). These functions relate to the ability of B cells to bind and present antigens. Under serum-free conditions we observed that
Externí odkaz:
https://doaj.org/article/22fdb0ecb83949ab83c8234014b9ec3a
Autor:
Hans Carl Hasselbalch, Trine Henriksen, Sif Gudbrandsdottir, Marie Klinge Brimnes, Mads Emil Bjørn, Christen Lykkegaard Andersen, Claus Henrik Nielsen, Henrik E. Poulsen
Publikováno v:
Leukemialymphoma. 60(10)
The role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been suggested to be important factors in disease initiation and pr
Autor:
Sif Gudbrandsdottir, Hans Carl Hasselbalch, Marie Klinge Brimnes, Tania Køllgaard, Claus Henrik Nielsen
Publikováno v:
European journal of haematology. 100(1)
Background B-cell depletion with rituximab (RTX) is widely accepted as first- or second-line therapy in primary immune thrombocytopenia (ITP), but it is still unclear how RTX mediates its positive effect in ITP patients. RTX has been reported to indu
Autor:
Christian Nielsen, Palle Holmstrup, Yaseelan Palarasah, Christian Kroun Damgaard, Jesper Reinholdt, Marie Klinge Brimnes, Christian Enevold, Claus Henrik Nielsen
Publikováno v:
Damgaard, C, Reinholdt, J, Palarasah, Y, Enevold, C, Nielsen, C, Brimnes, M K, Holmstrup, P & Nielsen, C H 2017, ' In vitro complement activation, adherence to red blood cells and induction of mononuclear cell cytokine production by four strains of Aggregatibacter actinomycetemcomitans with different fimbriation and expression of leukotoxin ', Journal of Periodontal Research, vol. 52, no. 3, pp. 485-496 . https://doi.org/10.1111/jre.12414
BACKGROUND AND OBJECTIVE: The periodontal pathogen Aggregatibacter actinomycetemcomitans has been proposed as pro-atherogenic, and complement-mediated adherence to red blood cells (RBCs) may facilitate its systemic spread. We investigated the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541e43130121914aa48912b19de40860
https://pure.au.dk/portal/da/publications/in-vitro-complement-activation-adherence-to-red-blood-cells-and-induction-of-mononuclear-cell-cytokine-production-by-four-strains-of-aggregatibacter-actinomycetemcomitans-with-different-fimbriation-and-expression-of-leukotoxin(59c52282-8bb2-4da4-bf9d-4d0c100989d5).html
https://pure.au.dk/portal/da/publications/in-vitro-complement-activation-adherence-to-red-blood-cells-and-induction-of-mononuclear-cell-cytokine-production-by-four-strains-of-aggregatibacter-actinomycetemcomitans-with-different-fimbriation-and-expression-of-leukotoxin(59c52282-8bb2-4da4-bf9d-4d0c100989d5).html
Publikováno v:
PLoS ONE
Nielsen, C H, Börnsen, L, Sellebjerg, F & Brimnes, M K 2016, ' Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis ', PLOS ONE, vol. 11, no. 1, e0146971 . https://doi.org/10.1371/journal.pone.0146971
PLoS ONE, Vol 11, Iss 1, p e0146971 (2016)
Nielsen, C H, Börnsen, L, Sellebjerg, F & Brimnes, M K 2016, ' Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis ', PLOS ONE, vol. 11, no. 1, e0146971 . https://doi.org/10.1371/journal.pone.0146971
PLoS ONE, Vol 11, Iss 1, p e0146971 (2016)
B cells are involved in driving relapsing-remitting multiple sclerosis (RRMS), as demonstrated by the positive effect of therapeutic B-cell depletion. Aside from producing antibodies, B cells are efficient antigen-presenting and cytokine-secreting ce
Autor:
Marie Klinge Brimnes, Hans Carl Hasselbalch, Caroline Hasselbalch Riley, Ole Weis Bjerrum, Per thor Straten, Inge Marie Svane, Morten K. Jensen
Publikováno v:
Blood. 118:2170-2173
Recent reports have described complete or major molecular remission in patients with polycythemia vera after long-term treatment with the immunomodulatory agent IFN-α2. Accordingly, there are reasons to believe that the immune system is a key player
Publikováno v:
Scandinavian Journal of Immunology. 73:222-233
In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-α and IL-2. The regulatory subset of CD4 T ce
Autor:
Marie Klinge Brimnes, Peter Gimsing, Lene Meldgaard Knudsen, Inge Marie Svane, Hans Erik Johnsen, Annette Juul Vangsted, Anne Ortved Gang
Publikováno v:
Scandinavian Journal of Immunology. 72:540-547
Patients with multiple myeloma (MM) suffer from a general impaired immunity comprising deficiencies in humoral responses, T-cell responses as well as dendritic cell (DC) function. Thus, to achieve control of tumour growth through immune therapy const
Publikováno v:
Journal of Immunotherapy. 33:425-434
Regulatory T cells (Treg) play an important role in the maintenance of immune tolerance and may be one of the obstacles of successful tumor immunotherapy. In this study, we analyzed the impact of administration of dendritic cell (DC) vaccination in c
Autor:
Marie Klinge Brimnes, Per thor Straten, Morten K. Jensen, Caroline Hasselbalch Riley, Inge Marie Svane, Morten Hartvig Hansen, Lasse Kjær, Hans Carl Hasselbalch
Publikováno v:
European journal of haematology. 97(1)
Long-term therapy with IFN-α2 is associated with sustained major molecular remissions in JAK2-positive ET and PV. The efficacy of IFN-α2 may be partly mediated by modulation of immune cells, which was investigated in twenty patients with ET (n = 6)