Zobrazeno 1 - 10
of 414
pro vyhledávání: '"Marie José Goumans"'
Publikováno v:
SLAS Discovery, Vol 29, Iss 8, Pp 100196- (2024)
Targeting transforming growth factor-β (TGF-β) receptors is a promising pharmacological approach to normalize aberrant signaling in genetic and non-genetic TGF-β associated diseases including fibrosis, cancer, cardiovascular and musculoskeletal di
Externí odkaz:
https://doaj.org/article/26fa8b004f2a42ff99e746cff2cda2e0
Autor:
Fjodor T. Bekedam, Rowan Smal, Marisa C. Smit, Jurjan Aman, Anton Vonk-Noordegraaf, Harm Jan Bogaard, Marie José Goumans, Frances S. De Man, Aida Llucià-Valldeperas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cardiac fibrosis contributes to the development of heart failure, and is the response of cardiac fibroblasts (CFs) to pressure or volume overload. Limiting factors in CFs research are the poor availability of human cells and the tendency of
Externí odkaz:
https://doaj.org/article/585c620b0a47474eb2356249f8333fef
Autor:
Josephina J. H. M. Smits, Atze van der Pol, Marie José Goumans, Carlijn V. C. Bouten, Ignasi Jorba
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The dynamic nature of the extracellular matrix (ECM), particularly its stiffness, plays a pivotal role in cellular behavior, especially after myocardial infarction (MI), where cardiac fibroblasts (cFbs) are key in ECM remodeling. This study explores
Externí odkaz:
https://doaj.org/article/4bd0c4fb846e400587fcb09ea42e9ca1
Autor:
Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background After myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial dysfunction. Direct reprogramming of fibroblasts into cardiomyocytes via the forced overexpression of
Externí odkaz:
https://doaj.org/article/e3965e3745d94f5a8c07effa85a5711d
Autor:
Fjodor T. Bekedam, Rowan Smal, Marisa C. Smit, Jurjan Aman, Anton Vonk-Noordegraaf, Harm Jan Bogaard, Marie José Goumans, Frances S. De Man, Aida Llucià-Valldeperas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e041030132584805b5d09a4c75abe8f1
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract SMAD6 encodes an intracellular inhibitor of the bone morphogenetic protein (BMP) signalling pathway. Until now, SMAD6-deficiency has been associated with three distinctive human congenital conditions, i.e., congenital heart diseases, includi
Externí odkaz:
https://doaj.org/article/d10fee9271ae46c5ade1913b37a3a51e
Autor:
Thomas C. L. Bracco Gartner, Sandra Crnko, Laurynas Leiteris, Iris van Adrichem, Linda W. van Laake, Carlijn V. C. Bouten, Marie José Goumans, Willem J. L. Suyker, Joost P. G. Sluijter, Jesper Hjortnaes
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
A fundamental process in the development and progression of heart failure is fibrotic remodeling, characterized by excessive deposition of extracellular matrix proteins in response to injury. Currently, therapies that effectively target and reverse c
Externí odkaz:
https://doaj.org/article/9e7e4afc48db4fedbeafb5ecf7228b0f
Autor:
Esther Dronkers, Tessa van Herwaarden, Thomas J van Brakel, Gonzalo Sanchez-Duffhues, Marie-José Goumans, Anke M Smits
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The epicardium, the mesothelial layer covering the heart, is a crucial cell source for cardiac development and repair. It provides cells and biochemical signals to the heart to facilitate vascularization and myocardial growth. An essential element of
Externí odkaz:
https://doaj.org/article/806a16335a1a4e74b0686f399d3fb8b4
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Despite the increasing success of interventional coronary reperfusion strategies, mortality related to acute myocardial infarction (MI) is still substantial. MI is defined as sudden death of myocardial tissue caused by an ischemic episode. Ischaemia
Externí odkaz:
https://doaj.org/article/4d3831eae5ed44b480ca2e9d3edf421a
Autor:
Peter M. Quinn, Thilo M. Buck, Aat A. Mulder, Charlotte Ohonin, C. Henrique Alves, Rogier M. Vos, Monika Bialecka, Tessa van Herwaarden, Elon H.C. van Dijk, Mays Talib, Christian Freund, Harald M.M. Mikkers, Rob C. Hoeben, Marie-José Goumans, Camiel J.F. Boon, Abraham J. Koster, Susana M. Chuva de Sousa Lopes, Carolina R. Jost, Jan Wijnholds
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 906-919 (2019)
Summary: Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to confirm the localization of proteins in retinal cell types and to test transduction and expression patterns of gene therapy vectors. Here, we compared the on
Externí odkaz:
https://doaj.org/article/67c05bc391cb49d7ae515f5b1d33c590