Impact of alginate composition: from bead mechanical properties to encapsulated HepG2/C3A cell activities for in vivo implantation.

Autor: Stephanie H Capone, Murielle Dufresne, Mathias Rechel, Marie-José Fleury, Anne-Virginie Salsac, Patrick Paullier, Martine Daujat-Chavanieu, Cecile Legallais

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62032 (2013)

Recently, interest has focused on hepatocytes' implantation to provide end stage liver failure patients with a temporary support until spontaneous recovery or a suitable donor becomes available. To avoid cell damage and use of an immunosuppressive tr

Externí odkaz: https://doaj.org/article/855e3726e6904369af260785a700d72f

Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: Metabolomics and gene expression study

Autor: Eric Leclerc, Guillaume Tcherkez, Rachid Jellali, Marie José Fleury, Audrey Legendre, Sébastien Jacques, Perrine Zeller, Françoise Gilard

Publikováno v: Environmental Toxicology and Pharmacology
Environmental Toxicology and Pharmacology, Elsevier, 2018, 59, pp.1-12. ⟨10.1016/j.etap.2018.02.004⟩

International audience; Dichlorodiphenyl-trichloroethane (DDT) and permethrin (PMT) are amongst most prevalent pesticides in the environment. Although their toxicity has been extensively studied, molecular mechanisms and metabolic effects remain uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7f1c3c87f7bf31291a1a63a5b9ecf9
https://doi.org/10.1016/j.etap.2018.02.004

Long-term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drug metabolism compared with Petri cultures

Autor: Sébastien Jacques, Patrick Paullier, Rachid Jellali, Franck Merlier, Marie José Fleury, Eric Leclerc, Thibault Bricks

Publikováno v: Biopharmaceutics & Drug Disposition. 37:264-275

Human primary hepatocytes were cultivated in a microfluidic bioreactor and in Petri dishes for 13 days. mRNA kinetics in biochips showed an increase in the levels of CYP2B6, CYP2C19, CYP2C8, CYP3A4, CYP1A2, CYP2D6, HNF4a, SULT1A1, UGT1A1 mRNA related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbbaa3a4d58a5a8af8704317c83dc69f
https://doi.org/10.1002/bdd.2010

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

Autor: Alexandre Seyer, Yves Edouard Herpe, Franck Merlier, Jeremy Hamon, Thibault Bricks, Jean-Marc Regimbeau, Rachid Jellali, Eric Leclerc, Marie José Fleury, Frédéric Y. Bois

Publikováno v: Biopharmaceutics & Drug Disposition. 36:275-293

A new in vitro microfluidic platform (integrated insert dynamic microfluidic platform, IIDMP) allowing the co-culture of intestinal Caco-2 TC7 cells and of human primary hepatocytes was used to test the absorption and first-pass metabolism of two dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75c403b00857a23f1a8d84a77fce18a3
https://doi.org/10.1002/bdd.1940

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

Autor: Thibault, Bricks, Jérémy, Hamon, Marie José, Fleury, Rachid, Jellali, Franck, Merlier, Yves Edouard, Herpe, Alexandre, Seyer, Jean-Marc, Regimbeau, Frédéric, Bois, Eric, Leclerc

Publikováno v: Biopharmaceuticsdrug disposition. 36(5)

A new in vitro microfluidic platform (integrated insert dynamic microfluidic platform, IIDMP) allowing the co-culture of intestinal Caco-2 TC7 cells and of human primary hepatocytes was used to test the absorption and first-pass metabolism of two dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83862b0201efab8c02609bffb06e77ca
https://pubmed.ncbi.nlm.nih.gov/25678106