Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marie Johne"'
Publikováno v:
Current Research in Neurobiology, Vol 6, Iss , Pp 100124- (2024)
Background: In children, hearing loss has been associated with hyperactivity, disturbed social interaction, and risk of cognitive disturbances. Mechanistic explanations of these relations sometimes involve language. To investigate the effect of heari
Externí odkaz:
https://doaj.org/article/5c40b13fd6d4414789a04f2c1b2bb852
Autor:
Marie Johne, Simeon O. A. Helgers, Mesbah Alam, Jonas Jelinek, Peter Hubka, Joachim K. Krauss, Verena Scheper, Andrej Kral, Kerstin Schwabe
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
BackgroundHearing loss was proposed as a factor affecting development of cognitive impairment in elderly. Deficits cannot be explained primarily by dysfunctional neuronal networks within the central auditory system. We here tested the impact of heari
Externí odkaz:
https://doaj.org/article/0148df4b325d4aee9069c93e1320e1eb
Autor:
Philip Hampel, Marie Johne, Björn Gailus, Alexandra Vogel, Alina Schidlitzki, Birthe Gericke, Kathrin Töllner, Wiebke Theilmann, Christopher Käufer, Kerstin Römermann, Kai Kaila, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105297- (2021)
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of
Externí odkaz:
https://doaj.org/article/2a709dc4887c4da59a0cb341c6f812df
Autor:
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105227- (2021)
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for develo
Externí odkaz:
https://doaj.org/article/ebf73ea039fa4ed9bcb04004def2080c
Autor:
Kerstin Römermann, Marie Johne, Björn Gailus, Lisa Welzel, Kai Kaila, Hannah Naundorf, Wolfgang Löscher
Publikováno v:
Epilepsia. 62:2826-2844
Objective: Birth asphyxia is a major cause of hypoxic-ischemic encephalopathy (HIE) in neonates and often associated with mortality, neonatal seizures, brain damage, and later life motor, cognitive, and behavioral impairments and epilepsy. Preclinica
Publikováno v:
Annals of neurology.
Birth asphyxia (BA) is the most frequent cause of neonatal death as well as CNS injury. BA is often associated with neonatal seizures, which only poorly respond to anti-seizure medications and may contribute to the adverse neurodevelopmental outcome.
Publikováno v:
Epilepsy & Behavior. 142:109189
Autor:
Christopher Käufer, Kerstin Römermann, Birthe Gericke, Wolfgang Löscher, Marie Johne, Björn Gailus
Publikováno v:
EpilepsiaREFERENCES. 62(6)
Objectives Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures. This suggestion was based on the idea that bumetanide, by reducing intraneuronal chloride accumulation through inhibition of the Na-K-2Cl cotrans
Autor:
Kerstin Römermann, Wiebke Theilmann, Kai Kaila, Philip Hampel, Wolfgang Löscher, Björn Gailus, Marie Johne, Tommi Ala-Kurikka
Objective: Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital is currently the most widely used antiseizure drug for treatment of neonata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6801fabde75fe31b03d45d3645e14
http://hdl.handle.net/10138/333660
http://hdl.handle.net/10138/333660
Autor:
Birthe Gericke, Björn Gailus, Marie Johne, Wolfgang Löscher, Philip Hampel, Kerstin Römermann, Edith Kaczmarek
Publikováno v:
Neuropharmacology. 185
The sodium-potassium-chloride (Na-K-Cl) cotransporter NKCC1 is found in the plasma membrane of a wide variety of cell types, including neurons, glia and endothelial cells in the brain. Increased expression of neuronal NKCC1 has been implicated in sev