Establishment of a stable transfection and gene targeting system in Babesia divergens

Autor: Eliana F. G. Cubillos, Pavla Snebergerova, Sarka Borsodi, Dominika Reichensdorferova, Viktoriya Levytska, Masahito Asada, Daniel Sojka, Marie Jalovecka

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Babesia divergens is an emerging tick-borne pathogen considered as the principal causative agent of bovine babesiosis in Europe with a notable zoonotic risk to human health. Despite its increasing impact, considerable gaps persist in our understandin

Externí odkaz: https://doaj.org/article/6a727511df3b4f54b78e335ce30f4fbc

Validation of Babesia proteasome as a drug target

Autor: Marie Jalovecka, David Hartmann, Yukiko Miyamoto, Lars Eckmann, Ondrej Hajdusek, Anthony J. O'Donoghue, Daniel Sojka

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 394-402 (2018)

Babesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Treatment of this emerging malaria-related disease has relied on antimalarial drugs and antibiotics. The proteasome of Plasmodium, the causative agent of

Externí odkaz: https://doaj.org/article/7aed7007bc3b4a1595d5b766bd2056b9

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

Autor: Radek Sima, Sabína Havlíková, Ryan O. M. Rego, Sarah Knorr, Ondrej Hajdusek, Martina Ličková, Monika Sláviková, Juan Anguita, Marie Jalovecka, Boris Klempa, Tal Azagi, Ard M. Nijhof, Jos J. A. Trentelman, Libor Grubhoffer, Julen Tomás-Cortázar, Joppe W. Hovius, Martin Strnad, Hein Sprong, Petr Kopáček

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-20 (2019)
Parasites & Vectors

Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baed8a7adf8fb19a4d84f91fd767ba1
http://link.springer.com/article/10.1186/s13071-019-3468-x

IrC2/Bf – A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus

Autor: Petr Kopáček, Marie Jalovecka, Radek Sima, Zdeněk Franta, Veronika Urbanová, Pavla Bartošová-Sojková, Helena Hönig-Mondeková, Ondřej Hajdušek, Lenka Grunclová

Publikováno v: Developmental & Comparative Immunology. 79:86-94

Ticks possess components of a primordial complement system that presumably play a role in the interaction of the tick immune system with tick-borne pathogens and affect their transmission. Here we characterized a novel complement component, tagged as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cc747bbd1ca5490d0128be74805a7e
https://doi.org/10.1016/j.dci.2017.10.012

Validation of Babesia proteasome as a drug target

Autor: Yukiko Miyamoto, Anthony J. O’Donoghue, Marie Jalovecka, Lars Eckmann, Daniel Sojka, Ondrej Hajdusek, David Hartmann

Publikováno v: International journal for parasitology. Drugs and drug resistance, vol 8, iss 3
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 394-402 (2018)

Babesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Treatment of this emerging malaria-related disease has relied on antimalarial drugs and antibiotics. The proteasome of Plasmodium, the causative agent of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5623ae688ad837b496a820bfaf98e7
https://escholarship.org/uc/item/6rv665g4